Search Results - "Clemens, James C."

Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe by Zipursky, S Lawrence, Luo, Liqun, Zhu, Haitao, Hummel, Thomas, Clemens, James C, Berdnik, Daniela

“…In the olfactory system of Drosophila melanogaster, axons of olfactory receptor neurons (ORNs) and dendrites of second-order projection neurons typically…”
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Use of Double-Stranded RNA Interference in Drosophila Cell Lines to Dissect Signal Transduction Pathways by Clemens, James C., Worby, Carolyn A., Simonson-Leff, Nancy, Muda, Marco, Maehama, Tomohiko, Hemmings, Brian A., Dixon, Jack E.

“…We demonstrate the efficacy of double-stranded RNA-mediated interference (RNAi) of gene expression in generating "knock-out" phenotypes for specific proteins…”
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Analysis of Dscam Diversity in Regulating Axon Guidance in Drosophila Mushroom Bodies by Zhan, Xiao-Li, Clemens, James C., Neves, Guilherme, Hattori, Daisuke, Flanagan, John J., Hummel, Thomas, Vasconcelos, M.Luisa, Chess, Andrew, Zipursky, S.Lawrence

“…Dscam is an immunoglobulin (Ig) superfamily member that regulates axon guidance and targeting in Drosophila. Alternative splicing potentially generates 38,016…”
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Blocking Apoptotic Signaling Rescues Axon Guidance in Netrin Mutants by Newquist, Gunnar, Drennan, J. Michelle, Lamanuzzi, Matthew, Walker, Kirsti, Clemens, James C., Kidd, Thomas

“…Netrins are guidance cues that form gradients to guide growing axons. We uncover a mechanism for axon guidance by demonstrating that axons can accurately…”
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Axonal Targeting of Olfactory Receptor Neurons in Drosophila Is Controlled by Dscam by Hummel, Thomas, Vasconcelos, Maria Luisa, Clemens, James C., Fishilevich, Yelena, Vosshall, Leslie B., Zipursky, S.Lawrence

“…Different classes of olfactory receptor neurons (ORNs) in Drosophila innervate distinct targets, or glomeruli, in the antennal lobe of the brain. Here we…”
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Mad is required for wingless signaling in wing development and segment patterning in Drosophila by Eivers, Edward, Fuentealba, Luis C, Sander, Veronika, Clemens, James C, Hartnett, Lori, De Robertis, E M

“…A key question in developmental biology is how growth factor signals are integrated to generate pattern. In this study we investigated the integration of the…”
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Drosophila activated Cdc42 kinase has an anti-apoptotic function by Schoenherr, Jessica A, Drennan, J Michelle, Martinez, Juan S, Chikka, Madhusudana Rao, Hall, Mark C, Chang, Henry C, Clemens, James C

“…Activated Cdc42 kinases (Acks) are evolutionarily conserved non-receptor tyrosine kinases. Activating somatic mutations and increased ACK1 protein levels have…”
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Functional Characterization of HFR1, a High-Mannose N-Glycan-Specific Wheat Lectin Induced by Hessian Fly Larvae by Subramanyam, Subhashree, Smith, David F., Clemens, James C., Webb, Mary A., Sardesai, Nagesh, Williams, Christie E.

“…We previously cloned and characterized a novel jacalin-like lectin gene from wheat (Triticum aestivum) plants that responds to infestation by Hessian fly…”
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Drosophila Ack Targets Its Substrate, the Sorting Nexin DSH3PX1, to a Protein Complex Involved in Axonal Guidance by Worby, Carolyn A., Simonson-Leff, Nancy, Clemens, James C., Huddler, Donald, Muda, Marco, Dixon, Jack E.

“…Dock, the Drosophila orthologue of Nck, is an adaptor protein that is known to function in axonal guidance paradigms in the fly including proper development of…”
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Alternative Splicing of Drosophila Dscam Generates Axon Guidance Receptors that Exhibit Isoform-Specific Homophilic Binding by Wojtowicz, Woj M., Flanagan, John J., Millard, S.Sean, Zipursky, S.Lawrence, Clemens, James C.

“…Dscam is an immunoglobulin (Ig) superfamily protein required for the formation of neuronal connections in Drosophila. Through alternative splicing, Dscam…”
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Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity by Schmucker, D, Clemens, J C, Shu, H, Worby, C A, Xiao, J, Muda, M, Dixon, J E, Zipursky, S L

“…A Drosophila homolog of human Down syndrome cell adhesion molecule (DSCAM), an immunoglobulin superfamily member, was isolated by its affinity to Dock, an…”
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Drosophila Vap-33 is required for axonal localization of Dscam isoforms by Yang, Zhen, Huh, Sung Un, Drennan, J Michelle, Kathuria, Hitesh, Martinez, Juan S, Tsuda, Hiroshi, Hall, Mark C, Clemens, James C

“…Mutations in VAPB have been identified in a familial form of amyotrophic lateral sclerosis (ALS), and reduced VAPB levels have been found in patients with…”
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Activated Cdc42 kinase regulates Dock localization in male germ cells during Drosophila spermatogenesis by Abdallah, Abbas M., Zhou, Xin, Kim, Christine, Shah, Kushani K., Hogden, Christopher, Schoenherr, Jessica A., Clemens, James C., Chang, Henry C.

“…Deregulation of the non-receptor tyrosine kinase ACK1 (Activated Cdc42-associated kinase) correlates with poor prognosis in cancers and has been implicated in…”
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Dendrite Self-Avoidance Is Controlled by Dscam by Matthews, Benjamin J., Kim, Michelle E., Flanagan, John J., Hattori, Daisuke, Clemens, James C., Zipursky, S. Lawrence, Grueber, Wesley B.

“…Dendrites distinguish between sister branches and those of other cells. Self-recognition can often lead to repulsion, a process termed “self-avoidance.” Here…”
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The organization and evolution of the dipteran and hymenopteran Down syndrome cell adhesion molecule (Dscam) genes by Graveley, Brenton R, Kaur, Amardeep, Gunning, Dorian, Zipursky, S Lawrence, Rowen, Lee, Clemens, James C

“…The Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam) gene encodes an axon guidance receptor and can generate 38,016 different isoforms via…”
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Functional Characterization of HFR1, a High-Mannose N-Glycan-Specific Wheat Lectin Induced by Hessian Fly Larvae1[C][W] by Subramanyam, Subhashree, Smith, David F, Clemens, James C, Webb, Mary A, Sardesai, Nagesh, Williams, Christie E

“…We previously cloned and characterized a novel jacalin-like lectin gene from wheat (Triticum aestivum) plants that responds to infestation by Hessian fly…”
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The Sorting Nexin, DSH3PX1, Connects the Axonal Guidance Receptor, Dscam, to the Actin Cytoskeleton by Worby, Carolyn A., Simonson-Leff, Nancy, Clemens, James C., Kruger, Robert P., Muda, Marco, Dixon, Jack E.

“…Dock, an adaptor protein that functions in Drosophila axonal guidance, consists of three tandem Src homology 3 (SH3) domains preceding an SH2 domain. To…”
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Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases by Muda, Marco, Worby, Carolyn A, Simonson-Leff, Nancy, Clemens, James C, Dixon, Jack E

“…Despite the wealth of information generated by genome-sequencing projects, the identification of in vivo substrates of specific protein kinases and…”
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Overproduction and One-step Purification of Escherichia coli 3-Deoxy-D-manno-octulosonic Acid 8-Phosphate Synthase and Oxygen Transfer Studies during Catalysis Using Isotopic-shifted Heteronuclear NMR by Dotson, Garry D., Dua, Rajesh K., Clemens, James C., Wooten, E. Wrenn, Woodard, Ronald W.

“…The enzyme 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase catalyzes the condensation of D-arabinose 5-phosphate with phosphoenolpyruvate to give the…”
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A Drosophila Protein-tyrosine Phosphatase Associates with an Adapter Protein Required for Axonal Guidance by Clemens, James C., Ursuliak, Zenovia, Clemens, Kristina K., Price, James V., Dixon, Jack E.

“…We have used the yeast two-hybrid system to isolate a novel Drosophila adapter protein, which interacts with the Drosophila protein-tyrosine phosphatase (PTP)…”
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