Search Results - "Clemens, James A."

Cerebral ischemia: gene activation, neuronal injury, and the protective role of antioxidants by Clemens, James A

“…A large number of gene products appear after an ischemic insult making it difficult to decipher which genes are involved in tissue injury. Reactive oxygen…”
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Reactive glia express cytosolic phospholipase A2 after transient global forebrain ischemia in the rat by Clemens, J A, Stephenson, D T, Smalstig, E B, Roberts, E F, Johnstone, E M, Sharp, J D, Little, S P, Kramer, R M

“…Phospholipid breakdown has been reported to be an early event in the brain after global cerebral ischemia. Our earlier observations showing the localization of…”
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Cytosolic Phospholipase A2(cPLA2) Immunoreactivity Is Elevated in Alzheimer's Disease Brain by Stephenson, Diane T., Lemere, Cynthia A., Selkoe, Dennis J., Clemens, James A.

“…Phospholipase A2(PLA2) is the key enzyme that initiates the arachidonic acid cascade, which leads to the generation of multiple eicosanoid products. Many of…”
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Effect of delayed albumin hemodilution on infarction volume and brain edema after transient middle cerebral artery occlusion in rats by BELAYEV, L, BUSTO, R, ZHAO, W, CLEMENS, J. A, GINSBERG, M. D

“…The authors examined the effect of delayed high-concentration albumin therapy on ischemic injury in a highly reproducible model of middle cerebral artery (MCA)…”
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Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat by Stephenson, D T, Rash, K, Clemens, J A

“…The distribution of beta-amyloid precursor protein (APP) was examined immunocytochemically in rats subjected to focal cerebral ischemia by permanent occlusion…”
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Chronic dietary pergolide preserves nigrostriatal neuronal integrity in aged-Fischer-344 rats by Felten, D L, Felten, S Y, Fuller, R W, Romano, T D, Smalstig, E B, Wong, D T, Clemens, J A

“…Pergolide, a potent D2 presynaptic agonist with postsynaptic D2 agonist activity and some D1 agonist activity was administered in the diet (0.5 mg/kg/day) of…”
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Effects of LY231617 and angiotensin IV on ischemia-induced deficits in circular water maze and passive avoidance performance in rats by Wright, John W., Clemens, James A., Panetta, Jill A., Smalstig, E.Barry, Weatherly, LeighAnn Stubley, Kramár, EniköA., Pederson, Eric S., Mungall, Bruce H., Harding, Joseph W.

“…The antioxidant LY231617 has previously been shown to offer significant protection against postischemic cell death in the hippocampus and corpus striatum of…”
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Dopamine depletion protects striatal neurons from ischemia-induced cell death by Clemens, J A, Phebus, L A

“…Infusion of the dopamine neurotoxin 6-hydroxydopamine, unilaterally into the substantia nigra of rats, resulted in a unilateral depletion of dopamine in the…”
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Neuroprotection by LY341122, a novel inhibitor of lipid peroxidation, against focal ischemic brain damage in rats by Huh, Pil W, Belayev, Ludmila, Zhao, Weizhao, Clemens, James A, Panetta, Jill A, Busto, Raul, Ginsberg, Myron D

“…LY341122 (2-(3,5-di- t-butyl-4-hydroxyphenyl)-4-(2-(4-methylethylaminomethyl-phenyloxy)ethyl)oxazole) is a potent inhibitor of lipid peroxidation which has…”
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Synthesis and evaluation of the antiovulatory activity of a variety of melatonin analogs by Flaugh, Michael E, Crowell, Thomas A, Clemens, James A, Sawyer, Barry D

“…A series of melatonin analogues was synthesized and examined for ovulation-blocking activity. Deviation from the 5-methoxy group or substitution of the 1…”
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Metabotropic glutamate receptor activation in vivo induces intraneuronal amyloid immunoreactivity in guinea pig hippocampus by Stephenson, Diane T, Clemens, James A

“…Stimulation of metabotropic glutamate receptors in vitro has been shown to accelerate the breakdown of amyloid precursor protein (APP) to form increased…”
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Increase in insulin-like growth factor II receptor within ischemic neurons following focal cerebral infarction by Stephenson, D T, Rash, K, Clemens, J A

“…The mechanisms underlying the response of the brain to ischemia are not fully understood. Biochemical and morphological changes following neocortical…”
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Rat B2 Sequences Are Induced in the Hippocampal CA1 Region After Transient Global Cerebral Ischemia by Liu, Xiaodong, Clemens, James A., Yin, Tinggui, Stephenson, Diane T., Johnstone, Edward M., Du, Yansheng, Panetta, Jill A., Paul, Steven M., Little, Sheila P.

“…Global brain ischemia causes cell death in the CA1 region of the hippocampus 3–5 days after reperfusion. The biological pathway leading to such delayed…”
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Ischemia increases tissue and decreases extracellular levels of acid dopamine metabolites in the rat striatum: Further evidence for active transport of metabolites by Phebus, Lee A, Mincy, Ronald E, Clemens, James A

“…During 30 minutes of global forebrain ischemia in rats, striatal intracellular levels of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)…”
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Effects of a new antiestrogen, keoxifene (LY156758), on growth of carcinogen-induced mammary tumors and on LH and prolactin levels by Clemens, J A, Bennett, D R, Black, L J, Jones, C D

“…Keoxifene (LY156758) is a new benzothiophene-derived antiestrogen with an extremely low degree of estrogenicity. Administration of 1-20 mg/kg per day inhibited…”
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Release of histamine in rat hypothalamus and corpus striatum in vivo by Russell, W L, Henry, D P, Phebus, L A, Clemens, J A

“…Histamine has remained a putative neurotransmitter for many years, partially because some of the criteria necessary to define it as a central nervous system…”
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Synthesis and dopamine antagonist activity of 2-thioether derivatives of the ergoline ring system by Tupper, David E, Pullar, Ian A, Clemens, James A, Fairhurst, John, Risius, Francesca C, Timms, Graham H, Wedley, Susan

“…A series of 2-thioether derivatives of a number of clavine alkaloid (ergoline) ring systems have been synthesized and tested for dopamine antagonist activity…”
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Bicyclic and tricyclic ergoline partial structures. Rigid 3-(2-aminoethyl)pyrroles and 3- and 4-(2-aminoethyl)pyrazoles as dopamine agonists by Bach, Nicholas J, Kornfeld, Edmund C, Jones, Noel D, Chaney, Michael O, Dorman, Douglas E, Paschal, Jonathan W, Clemens, James A, Smalstig, E. Barry

“…It is proposed, based upon comparisons with apomorphine, that the rigid pyrroleethylamine moiety of the ergolines is the portion of the molecule responsible…”
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Synthesis and evaluation of N,N-di-n-propyltetrahydrobenz[f]indol-7-amine and related congeners as dopaminergic agonists by Nichols, David E, Cassady, John M, Persons, Paul E, Yeung, Ming C, Clemens, James A, Smalstig, E. Barry

“…An evaluation of 6-[2-(di-n-propylamino)ethyl]indole (4), its rigid analogue N,N-di-n-propyl-5,6,7,8-tetrahydrobenz[f]indol-7-amine (5), and some related…”
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Global ischemia activates nuclear factor-kappa B in forebrain neurons of rats by Clemens, J A, Stephenson, D T, Smalstig, E B, Dixon, E P, Little, S P

“…After global ischemia, brain levels of hydrogen peroxide, oxygen radicals, and the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta…”
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