Search Results - "Clemens, J A"

Tannins from Hamamelis virginiana bark extract: characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus by Theisen, Linda L, Erdelmeier, Clemens A J, Spoden, Gilles A, Boukhallouk, Fatima, Sausy, Aurélie, Florin, Luise, Muller, Claude P

“…Antiviral activity has been demonstrated for different tannin-rich plant extracts. Since tannins of different classes and molecular weights are often found…”
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Crataegus Extract WS®1442 Stimulates Cardiomyogenesis and Angiogenesis From Stem Cells: A Possible New Pharmacology for Hawthorn? by Halver, Jonas, Wenzel, Kristin, Sendker, Jandirk, Carrillo García, Carmen, Erdelmeier, Clemens A J, Willems, Erik, Mercola, Mark, Symma, Nico, Könemann, Stephanie, Koch, Egon, Hensel, Andreas, Schade, Dennis

“…Extracts from the leaves and flowers of spp. (i.e., hawthorn species) have been traditionally used with documented preclinical and clinical activities in…”
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Haemanthus coccineus extract and its main bioactive component narciclasine display profound anti‐inflammatory activities in vitro and in vivo by Fuchs, Simone, Hsieh, Louise T., Saarberg, Werner, Erdelmeier, Clemens A. J., Wichelhaus, Thomas A., Schaefer, Liliana, Koch, Egon, Fürst, Robert

“…Haemanthus coccineus extracts (HCE) have traditionally been used to treat a variety of diseases, like febrile colds or asthma. Since new therapeutic options…”
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Effect of delayed albumin hemodilution on infarction volume and brain edema after transient middle cerebral artery occlusion in rats by BELAYEV, L, BUSTO, R, ZHAO, W, CLEMENS, J. A, GINSBERG, M. D

“…The authors examined the effect of delayed high-concentration albumin therapy on ischemic injury in a highly reproducible model of middle cerebral artery (MCA)…”
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Selective estrogen receptor modulator effects of epimedium extracts on breast cancer and uterine growth in nude mice by Indran, Inthrani Raja, Zhang, Shi-Jun, Zhang, Zhi Wei, Sun, Feng, Gong, Yinhan, Wang, Xiaochong, Li, Jun, Erdelmeier, Clemens A J, Koch, Egon, Yong, Eu Leong

“…Epimedium is popularly used in traditional Chinese medicine to treat sexual dysfunction, menstrual irregularity, and osteoporosis. The estrogenic effects of…”
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The Dual Edema-Preventing Molecular Mechanism of the Crataegus Extract WS 1442 Can Be Assigned to Distinct Phytochemical Fractions by Fuchs, Simone, Bischoff, Iris, Willer, Elisabeth A, Bräutigam, Jacqueline, Bubik, Martin F, Erdelmeier, Clemens A J, Koch, Egon, Faleschini, Maria T, De Mieri, Maria, Bauhart, Milena, Zahler, Stefan, Hensel, Andreas, Hamburger, Matthias, Potterat, Olivier, Fürst, Robert

“…The hawthorn ( spp.) extract WS 1442 is used against mild forms of chronic heart failure. This disease is associated with endothelial barrier dysfunction and…”
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Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat by Stephenson, D T, Rash, K, Clemens, J A

“…The distribution of beta-amyloid precursor protein (APP) was examined immunocytochemically in rats subjected to focal cerebral ischemia by permanent occlusion…”
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Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity by Podlisny, MB, Stephenson, DT, Frosch, MP, Tolan, DR, Lieberburg, I, Clemens, JA, Selkoe, DJ

“…The cerebral deposition of amyloid beta protein (A beta P) is an early pathogenetic event in Alzheimer's disease (AD). Recent studies suggest both neurotoxic…”
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LY178002 reduces rat brain damage after transient global forebrain ischemia by CLEMENS, J. A, HO, P. P. K, PANETTA, J. A

“…Several feasible mechanisms have been proposed as sources of neuronal damage from ischemia and subsequent reperfusion. Included among these are oxidative…”
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Cerebral ischemia: gene activation, neuronal injury, and the protective role of antioxidants by Clemens, James A

“…A large number of gene products appear after an ischemic insult making it difficult to decipher which genes are involved in tissue injury. Reactive oxygen…”
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Effects of LY231617 and angiotensin IV on ischemia-induced deficits in circular water maze and passive avoidance performance in rats by Wright, John W., Clemens, James A., Panetta, Jill A., Smalstig, E.Barry, Weatherly, LeighAnn Stubley, Kramár, EniköA., Pederson, Eric S., Mungall, Bruce H., Harding, Joseph W.

“…The antioxidant LY231617 has previously been shown to offer significant protection against postischemic cell death in the hippocampus and corpus striatum of…”
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The antioxidant LY231617 reduces global ischemic neuronal injury in rats by Clemens, J A, Saunders, R D, Ho, P P, Phebus, L A, Panetta, J A

“…In the rat four-vessel occlusion model with 30 minutes of ischemia most agents have failed to be of benefit when given after ischemia. Because postischemia…”
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Increased expression of peripheral benzodiazepine receptors in the facial nucleus following motor neuron axotomy by Gehlert, Donald R., Stephenson, Diane T., Schober, Douglas A., Rash, Karen, Clemens, James A.

“…Peripheral benzodiazepine receptors (PBRs) are expressed in a variety of tissues but are normally found at low levels in the brain. Following various types of…”
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DNA as an Affinity Probe Useful in the Detection and Isolation of Biologically Active Natural Products by Pezzuto, John M, Che, Chun-Tao, McPherson, David D, Zhu, Ji-Ping, Topcu, Gulacti, Erdelmeier, Clemens A. J, Cordell, Geoffrey A

“…A simplified hplc system is described for the detection of compounds capable of binding to DNA. Compounds known to interact with DNA were found to invoke a…”
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Neuroprotection by LY341122, a novel inhibitor of lipid peroxidation, against focal ischemic brain damage in rats by Huh, Pil W, Belayev, Ludmila, Zhao, Weizhao, Clemens, James A, Panetta, Jill A, Busto, Raul, Ginsberg, Myron D

“…LY341122 (2-(3,5-di- t-butyl-4-hydroxyphenyl)-4-(2-(4-methylethylaminomethyl-phenyloxy)ethyl)oxazole) is a potent inhibitor of lipid peroxidation which has…”
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Metabotropic glutamate receptor activation in vivo induces intraneuronal amyloid immunoreactivity in guinea pig hippocampus by Stephenson, Diane T, Clemens, James A

“…Stimulation of metabotropic glutamate receptors in vitro has been shown to accelerate the breakdown of amyloid precursor protein (APP) to form increased…”
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Global cerebral ischemia activates nuclear factor- κB prior to evidence of DNA fragmentation by Clemens, James A, Stephenson, Diane T, Dixon, Eric P, Smalstig, E.Barry, Mincy, Ronald E, Rash, Karen S, Little, Sheila P

“…The oxidative stress responsive transcription factor nuclear factor- κB (NF- κB) consists of a p50 (50 kDa) and p65/RelA (65 kDa) component and can be…”
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Increase in insulin-like growth factor II receptor within ischemic neurons following focal cerebral infarction by Stephenson, D T, Rash, K, Clemens, J A

“…The mechanisms underlying the response of the brain to ischemia are not fully understood. Biochemical and morphological changes following neocortical…”
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Effects of transient, global, cerebral ischemia on striatal extracellular dopamine, serotonin and their metabolites by Phebus, L A, Clemens, J A

“…Rat striatal extracellular fluid levels of dopamine, serotonin, 3-methoxytyramine (3-MT), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and…”
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Global ischemia activates nuclear factor-kappa B in forebrain neurons of rats by Clemens, J A, Stephenson, D T, Smalstig, E B, Dixon, E P, Little, S P

“…After global ischemia, brain levels of hydrogen peroxide, oxygen radicals, and the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta…”
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