Search Results - "Clegg, John R."

Hydrogels in the clinic by Mandal, Abhirup, Clegg, John R., Anselmo, Aaron C., Mitragotri, Samir

“…Injectable hydrogels are one of the most widely investigated and versatile technologies for drug delivery and tissue engineering applications. Hydrogels’…”
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Modular Fabrication of Intelligent Material-Tissue Interfaces for Bioinspired and Biomimetic Devices by Clegg, John R, Wagner, Angela M, Shin, Su Ryon, Hassan, Shabir, Khademhosseini, Ali, Peppas, Nicholas A

“…One of the goals of biomaterials science is to reverse engineer aspects of human and nonhuman physiology. Similar to the body's regulatory mechanisms, such…”
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Cell therapies in the clinic by Wang, Lily Li‐Wen, Janes, Morgan E., Kumbhojkar, Ninad, Kapate, Neha, Clegg, John R., Prakash, Supriya, Heavey, Mairead K., Zhao, Zongmin, Anselmo, Aaron C., Mitragotri, Samir

“…Cell therapies have emerged as a promising therapeutic modality with the potential to treat and even cure a diverse array of diseases. Cell therapies offer…”
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Hydrogels in the clinic: An update by Clegg, John R., Adebowale, Kolade, Zhao, Zongmin, Mitragotri, Samir

“…Hydrogels have been used in the clinic since the late 1980s with broad applications in drug delivery, cosmetics, tissue regeneration, among many other areas…”
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Non-spherical micro- and nanoparticles for drug delivery: Progress over 15 years by Kapate, Neha, Clegg, John R., Mitragotri, Samir

“…[Display omitted] Shape of particulate drug carries has been identified as a key parameter in determining their biological outcome. In this review, we analyze…”
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Analyte-Responsive Hydrogels: Intelligent Materials for Biosensing and Drug Delivery by Culver, Heidi R, Clegg, John R, Peppas, Nicholas A

“…Nature has mastered the art of molecular recognition. For example, using synergistic non-covalent interactions, proteins can distinguish between molecules and…”
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Intrathecal delivery of Macromolecules: Clinical status and emerging technologies by Ajeeb, Rana, Clegg, John R.

“…[Display omitted] The proximity and association of cerebrospinal fluid (CSF) and the intrathecal (IT) space with deep targets in the central nervous system…”
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Self-therapeutic nanomaterials: Applications in biology and medicine by Seaberg, Joshua, Clegg, John R., Bhattacharya, Resham, Mukherjee, Priyabrata

“…[Display omitted] Over past decades, nanotechnology has contributed to the biomedical field in areas including detection, diagnosis, and drug delivery via…”
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Design of Synthetic Hydrogel Compositions for Noncovalent Protein Recognition by Clegg, John R., Peppas, Nicholas A.

“…Multifunctional hydrogels composed of segments with ionizable, hydrophilic, and hydrophobic monomers have been optimized for sensing, bioseparation, and…”
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QCM‐D assay for quantifying the swelling, biodegradation, and protein adsorption of intelligent nanogels by Clegg, John R., Ludolph, Catherine M., Peppas, Nicholas A.

“…ABSTRACT Environmentally responsive nanomaterials have been developed for drug delivery applications, in an effort to target and accumulate therapeutic agents…”
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A backpack-based myeloid cell therapy for multiple sclerosis by Kapate, Neha, Dunne, Michael, Kumbhojkar, Ninad, Prakash, Supriya, Wang, Lily Li-Wen, Graveline, Amanda, Park, Kyung Soo, Chandran Suja, Vineeth, Goyal, Juhee, Clegg, John R, Mitragotri, Samir

“…Multiple sclerosis (MS) is an incurable autoimmune disease and is currently treated by systemic immunosuppressants with off-target side effects. Although…”
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Corrigendum to “Peptide conjugation enhances the cellular co-localization, but not endosomal escape, of modular poly (acrylamide-co-methacrylic acid) nanogels” [Journal of Controlled Release, 329, 1162–1171] by Clegg, John R., Sun, Jessie A., Gu, Joann, Venkataraman, Abhijeet K., Peppas, Nicholas A.

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Peptide conjugation enhances the cellular co-localization, but not endosomal escape, of modular poly(acrylamide-co-methacrylic acid) nanogels by Clegg, John R., Sun, Jessie A., Gu, Joann, Venkataraman, Abhijeet K., Peppas, Nicholas A.

“…Nanoparticles must recognize, adhere to, and/or traverse multiple barriers in sequence to achieve cytosolic drug delivery. New nanoparticles often exhibit a…”
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Analyte-Responsive Hydrogels: Intelligent Materials for Biosensing and Drug Delivery by Culver, Heidi R, Clegg, John R, Peppas, Nicholas A

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Polymer Composition Primarily Determines the Protein Recognition Characteristics of Molecularly Imprinted Hydrogels by Venkataraman, Abhijeet K, Clegg, John R, Peppas, Nicholas A

“…Synthetic hydrogels with the ability to recognize and bind target proteins are useful for a number of applications, including biosensing and therapeutic agent…”
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Tunable poly(methacrylic acid‐co‐acrylamide) nanoparticles through inverse emulsion polymerization by Zhong, Justin X., Clegg, John R., Ander, Eric W., Peppas, Nicholas A.

“…Environmentally responsive biomaterials have played key roles in the design of biosensors and drug delivery vehicles. Their physical response to external…”
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Optimization of Cationic Nanogel PEGylation to Achieve Mammalian Cytocompatibility with Limited Loss of Gram-Negative Bactericidal Activity by Gu, Joann, Clegg, John R, Heersema, Lara A, Peppas, Nicholas A, Smyth, Hugh D. C

“…Tuning the composition of antimicrobial nanogels can significantly alter both nanogel cytotoxicity and antibacterial activity. This project investigated the…”
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Preclinical characterization of macrophage-adhering gadolinium micropatches for MRI contrast after traumatic brain injury in pigs by Wang, Lily Li-Wen, Gao, Yongsheng, Chandran Suja, Vineeth, Boucher, Masen L, Shaha, Suyog, Kapate, Neha, Liao, Rick, Sun, Tao, Kumbhojkar, Ninad, Prakash, Supriya, Clegg, John R, Warren, Kaitlyn, Janes, Morgan, Park, Kyung Soo, Dunne, Michael, Ilelaboye, Bolu, Lu, Andrew, Darko, Solomina, Jaimes, Camilo, Mannix, Rebekah, Mitragotri, Samir

“…The choroid plexus (ChP) of the brain plays a central role in orchestrating the recruitment of peripheral leukocytes into the central nervous system (CNS)…”
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Sustained delivery of celecoxib from nanoparticles embedded in hydrogel injected into the biopsy cavity to prevent biopsy-induced breast cancer metastasis by Simmons, Reese, Kameyama, Hiroyasu, Kubota, Seiko, Sun, Yunguang, Langenheim, John F., Ajeeb, Rana, Shao, Tristan S., Ricketts, Samantha, Annan, Anand C., Stratemeier, Natalie, Williams, Sophie J., Clegg, John R., Fung, Kar-Ming, Chervoneva, Inna, Rui, Hallgeir, Tanaka, Takemi

“…Purpose We have previously reported that protracted Cyclooxygenase-2 (COX-2) activity in bone marrow-derived cells (BMDCs) infiltrating into biopsy wounds…”
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Synthetic networks with tunable responsiveness, biodegradation, and molecular recognition for precision medicine applications by Clegg, John R, Irani, Afshan S, Ander, Eric W, Ludolph, Catherine M, Venkataraman, Abhijeet K, Zhong, Justin X, Peppas, Nicholas A

“…Formulations and devices for precision medicine applications must be tunable and multiresponsive to treat heterogeneous patient populations in a calibrated and…”
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