Search Results - "Clegg, J B"

Inherited haemoglobin disorders : an increasing global health problem by WEATHERALL, D. J, CLEGG, J. B

“…Despite major advances in our understanding of the molecular pathology, pathophysiology, and control and management of the inherited disorders of haemoglobin,…”
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World distribution of factor V Leiden by Rees, D C, Cox, M, Clegg, J B

“…We have analysed 3380 chromosomes (1690 unrelated individuals) from twenty-four populations for the presence of factor V Leiden, an important risk factor in…”
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Rapid detection of α‐thalassaemia deletions and α‐globin gene triplication by multiplex polymerase chain reactions by LIU, Y. T, OLD, J. M, MILES, K, FISHER, C. A, WEATHERALL, D. J, CLEGG, J. B

“…We describe a sensitive, reliable and reproducible method, based on three multiplex PCR assays, for the rapid detection of seven common α‐thalassaemia…”
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Global distribution of the CCR5 gene 32-basepair deletion by Martinson, Jeremy J, Chapman, Nicola H, Rees, David C, Liu, Yan-Tat, Clegg, John B

“…A mutant allele of the beta-chemokine receptor gene CCR5 bearing a 32-basepair (bp) deletion (denoted delta ccr5) which prevents cell invasion by the primary…”
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Archaic African and Asian lineages in the genetic ancestry of modern humans by HARDING, R. M, FULLERTON, S. M, GRIFFITHS, R. C, BOND, J, COX, M. J, SCHNEIDER, J. A, MOULIN, D. S, CLEGG, J. B

“…A 3-kb region encompassing the beta-globin gene has been analyzed for allelic sequence polymorphism in nine populations from Africa, Asia, and Europe. A unique…”
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α+-Thalassemia Protects Children against Disease Caused by other Infections as Well as Malaria by Allen, S J, O'Donnell, A, Alexander, N D, Alpers, M P, Peto, T E, Clegg, J B, Weatherall, D J

“…In the South West Pacific region, the striking geographical correlation between the frequency of α+-thalassemia and the endemicity of Plasmodium falciparum…”
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Evidence for mitochondrial DNA recombination in a human population of island Melanesia by Hagelberg, E., Goldman, N., Lio, P., Whelan, S., Schiefenhovel, W., Clegg, J. B., Bowden, D. K.

“…Mitochondrial DNA (mtDNA) analysis has proved useful in studies of recent human evolution and the genetic affinities of human groups of different geographical…”
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High incidence of malaria in α-thalassaemic children by Williams, T. N, Maitland, K, Bennett, S, Ganczakowski, M, Peto, T. E. A, Newbold, C. I, Bowden, D. K, Weatherall, D. J, Clegg, J. B

“…The alpha+-thalassaemias are the commonest known human genetic disorders, affecting up to 80 per cent of some populations. Although there is good evidence from…”
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Worldwide Distribution of a Common Methylenetetrahydrofolate Reductase Mutation by Schneider, Julie A., Rees, David C., Liu, Yan-Tat, Clegg, John B.

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Thalassemia - a global public health problem by Weatherall, D.J, Clegg, J.B

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Genetic variability in response to infection: malaria and after by Weatherall, D J, Clegg, J B

“…Recent studies have shown that the relatively short period of exposure of human populations to malaria has left in its wake a wide range of genetic diversity…”
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The global distribution of length polymorphisms of the promoters of the glucuronosyltransferase 1 gene (UGT1A1): hematologic and evolutionary implications by Premawardhena, A, Fisher, C.A, Liu, Y.T, Verma, I.C, de Silva, S, Arambepola, M, Clegg, J.B, Weatherall, D.J

“…The promoter region of the UDP glucuronosyltransferase 1 gene (UGT1A1) contains a run of thymine-adenine (TA) repeats, usually six (TA) 6. As well as its…”
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α+‐Thalassaemia and pregnancy in a malaria endemic region of Papua New Guinea by O'Donnell, A., Raiko, A., Clegg, J.B., Weatherall, D.J., Allen, S.J.

“…Summary The effect of maternal α+‐thalassaemia on pregnancy was assessed in the north coastal region of Papua New Guinea (PNG), where malaria is hyperendemic…”
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Alpha thalassaemia is associated with increased soluble transferrin receptor levels by REES, D. C, WILLIAMS, T. N, MAITLAND, K, CLEGG, J. B, WEATHERALL, D. J

“…Although α+ thalassaemia is the commonest haemoglobinopathy in the world, it is not known if it is associated with significant ineffective erythropoiesis, a…”
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Thalassaemia in Sri Lanka: implications for the future health burden of Asian populations by de Silva, Shanthimala, Fisher, CA, Premawardhena, A, Lamabadusuriya, SP, Peto, TEA, Perera, Gayathri, Old, JM, Clegg, JB, Olivieri, Nancy F, Weatherall, DJ

“…Thalassaemias pose an increasing problem for the Indian subcontinent and many Asian countries. We analysed the different types of thalassaemia in the Sri…”
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Genetic Polymorphisms in Prehistoric Pacific Islanders Determined by Analysis of Ancient Bone DNA by Hagelberg, E., Clegg, John Brian

“…A previously characterized Asian-specific mitochondrial DNA (mtDNA) length mutation has been detected in DNA isolated from prehistoric human bones from…”
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Isolation and Characterization of DNA from Archaeological Bone by Hagelberg, Erika, Clegg, John Brian

“…DNA was extracted from human and animal bones recovered from archaeological sites and mitochondrial DNA sequences were amplified from the extracts using the…”
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Prevention of cerebral malaria in children in Papua New Guinea by southeast Asian ovalocytosis band 3 by Allen, S J, O'Donnell, A, Alexander, N D, Mgone, C S, Peto, T E, Clegg, J B, Alpers, M P, Weatherall, D J

“…Southeast Asian ovalocytosis (SAO) occurs at high frequency in malarious regions of the western Pacific and may afford a survival advantage against malaria. It…”
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Molecular and Population Genetic Analysis of Allelic Sequence Diversity at the Human β-Globin Locus by Fullerton, S. M., Harding, R. M., Boyce, A. J., Clegg, J. B.

“…Allelic sequence polymorphism at the β-globin locus was investigated in a group of 36 Melanesians. A 3-kilobase fragment containing the gene and its flanking…”
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DNA from ancient Easter Islanders by Hagelberg, Erika, Quevedo, Silvia, Turbon, Daniel, Clegg, J. B

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