Search Results - "Clegg, J"

Physiology and Pathophysiology of Potassium Homeostasis: Core Curriculum 2019 by Palmer, Biff F., Clegg, Deborah J.

“…Total-body potassium (K+) content and appropriate distribution of K+ across the cell membrane is vitally important for normal cellular function. Total-body K+…”
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The Role of Estrogens in Control of Energy Balance and Glucose Homeostasis by Mauvais-Jarvis, Franck, Clegg, Deborah J, Hevener, Andrea L

“…Estrogens play a fundamental role in the physiology of the reproductive, cardiovascular, skeletal, and central nervous systems. In this report, we review the…”
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Determinants of body fat distribution in humans may provide insight about obesity-related health risks by Frank, Aaron P., de Souza Santos, Roberta, Palmer, Biff F., Clegg, Deborah J.

“…Obesity increases the risks of developing cardiovascular and metabolic diseases and degrades quality of life, ultimately increasing the risk of death. However,…”
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Minireview: The Year in Review of Estrogen Regulation of Metabolism by Clegg, Deborah J

“…Gonadal steroids are critical regulators of physiology, yet we approach physiology and science with the simplest perspective/model, the male one. Female models…”
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Physiology and pathophysiology of potassium homeostasis by Palmer, Biff F, Clegg, Deborah J

“…Total body potassium content and proper distribution of potassium across the cell membrane is of critical importance for normal cellular function. Potassium…”
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Achieving the Benefits of a High-Potassium, Paleolithic Diet, Without the Toxicity by Palmer, Biff F., MD, Clegg, Deborah J., PhD

“…Abstract The average US dietary intake of K+ is well below the current recommended nutritional requirements. This deficiency is even more striking when…”
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Starvation Ketosis and the Kidney by Palmer, Biff F, Clegg, Deborah J

“…The remarkable ability of the body to adapt to long-term starvation has been critical for survival of primitive man. An appreciation of these processes can…”
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Non‐shivering thermogenesis as a mechanism to facilitate sustainable weight loss by Palmer, B. F., Clegg, D. J.

“…Summary Currently, there is a significant percentage of the population who are or will be classified as obese, necessitating novel strategies to facilitate…”
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The clinical effectiveness and cost-effectiveness of bariatric (weight loss) surgery for obesity: a systematic review and economic evaluation by Picot, J, Jones, J, Colquitt, J L, Gospodarevskaya, E, Loveman, E, Baxter, L, Clegg, A J

“…To assess the clinical effectiveness and cost-effectiveness of bariatric surgery for obesity. Seventeen electronic databases were searched [MEDLINE; EMBASE;…”
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Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction by Xu, Yong, Nedungadi, Thekkethil P., Zhu, Liangru, Sobhani, Nasim, Irani, Boman G., Davis, Kathryn E., Zhang, Xiaorui, Zou, Fang, Gent, Lana M., Hahner, Lisa D., Khan, Sohaib A., Elias, Carol F., Elmquist, Joel K., Clegg, Deborah J.

“…Estrogens regulate body weight and reproduction primarily through actions on estrogen receptor-α (ERα). However, ERα-expressing cells mediating these effects…”
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The effectiveness of continuous quality improvement for developing professional practice and improving health care outcomes: a systematic review by Hill, James E, Stephani, Anne-Marie, Sapple, Paul, Clegg, Andrew J

“…Efforts to improve the quality, safety, and efficiency of health care provision have often focused on changing approaches to the way services are organized and…”
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The role of hypothalamic estrogen receptors in metabolic regulation by Frank, Aaron, Brown, Lynda M, Clegg, Deborah J

“…Highlights • ERs regulate key features of metabolism. • ERS1 mutations recapitulate aspects of the metabolic syndrome. • ERS1 in female SF1 neurons regulates…”
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Developmental language disorders - a follow-up in later adult life. Cognitive, language and psychosocial outcomes by Clegg, J., Hollis, C., Mawhood, L., Rutter, M.

“…Background:  Little is known on the adult outcome and longitudinal trajectory of childhood developmental language disorders (DLD) and on the prognostic…”
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Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target by Chen, Yu, MD, Clegg, Nicola J, PhD, Scher, Howard I, Prof

“…Summary Activation of the androgen receptor is crucial for prostate cancer growth at all points of the illness. Current therapies targeting the androgen…”
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Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice by Holland, William L, Bikman, Benjamin T, Wang, Li-Ping, Yuguang, Guan, Sargent, Katherine M, Bulchand, Sarada, Knotts, Trina A, Shui, Guanghou, Clegg, Deborah J, Wenk, Markus R, Pagliassotti, Michael J, Scherer, Philipp E, Summers, Scott A

“…Obesity is associated with an enhanced inflammatory response that exacerbates insulin resistance and contributes to diabetes, atherosclerosis, and…”
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Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors by Meyer, M. R., Clegg, D. J., Prossnitz, E. R., Barton, M.

“…Obesity increases the risk of coronary artery disease through insulin resistance, diabetes, arterial hypertension and dyslipidemia. The prevalence of obesity…”
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The role of estrogens in the adipose tissue milieu by Bracht, John R., Vieira‐Potter, Victoria J., De Souza Santos, Roberta, Öz, Orhan K., Palmer, Biff F., Clegg, Deborah J.

“…One of the leading causes for the development of adverse metabolic effects, including type 2 diabetes, dyslipidemia, and cardiovascular diseases, is the…”
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microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice by Grove, K.L, Fried, S.K, Greenberg, A.S, Xiao, X.Q, Clegg, D.J

“…Objective: A sexual dimorphism exists in body fat distribution; females deposit relatively more fat in subcutaneous/inguinal depots whereas males deposit more…”
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Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer by Tran, Chris, Ouk, Samedy, Clegg, Nicola J, Chen, Yu, Watson, Philip A, Arora, Vivek, Wongvipat, John, Smith-Jones, Peter M, Yoo, Dongwon, Kwon, Andrew, Wasielewska, Teresa, Welsbie, Derek, Chen, Charlie Degui, Higano, Celestia S, Beer, Tomasz M, Hung, David T, Scher, Howard I, Jung, Michael E, Sawyers, Charles L

“…Metastatic prostate cancer is treated with drugs that antagonize androgen action, but most patients progress to a more aggressive form of the disease called…”
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Plasticity and fracture in drying colloidal films by Goehring, Lucas, Clegg, William J, Routh, Alexander F

“…Cracks in drying colloidal dispersions are typically modeled by elastic fracture mechanics, which assumes that all strains are linear, elastic, and reversible…”
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