Search Results - "Clegg, D. J."

Non‐shivering thermogenesis as a mechanism to facilitate sustainable weight loss by Palmer, B. F., Clegg, D. J.

“…Summary Currently, there is a significant percentage of the population who are or will be classified as obese, necessitating novel strategies to facilitate…”
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microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice by Grove, K.L, Fried, S.K, Greenberg, A.S, Xiao, X.Q, Clegg, D.J

“…Objective: A sexual dimorphism exists in body fat distribution; females deposit relatively more fat in subcutaneous/inguinal depots whereas males deposit more…”
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Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors by Meyer, M. R., Clegg, D. J., Prossnitz, E. R., Barton, M.

“…Obesity increases the risk of coronary artery disease through insulin resistance, diabetes, arterial hypertension and dyslipidemia. The prevalence of obesity…”
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Estrogen receptor 1 (ESR1) regulates VEGFA in adipose tissue by Fatima, L. A., Campello, R. S., Santos, R. de Souza, Freitas, H. S., Frank, A. P, Machado, U. F., Clegg, D. J.

“…Vascular endothelial growth factor A (VEGFA) is a key factor in the regulation of angiogenesis in adipose tissue. Poor vascularization during adipose tissue…”
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A sexually dimorphic hypothalamic response to chronic high-fat diet consumption by Morselli, E, Frank, A P, Palmer, B F, Rodriguez-Navas, C, Criollo, A, Clegg, D J

“…In this review, we discuss the observations that, following chronic high-fat diet (HFD) exposure, male mice have higher levels of saturated fatty acids (FAs)…”
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Sex differences in the regulation of body weight by Shi, H, Clegg, D.J

“…Abstract Obesity and its associated health disorders and costs are increasing. Males and females differ in terms of how and where body fat is stored, the…”
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Female Mice Lacking Estrogen Receptor-α in Hypothalamic Proopiomelanocortin (POMC) Neurons Display Enhanced Estrogenic Response on Cortical Bone Mass by Farman, H. H, Windahl, S. H, Westberg, L, Isaksson, H, Egecioglu, E, Schele, E, Ryberg, H, Jansson, J. O, Tuukkanen, J, Koskela, A, Xie, S. K, Hahner, L, Zehr, J, Clegg, D. J, Lagerquist, M. K, Ohlsson, C

“…Estrogens are important regulators of bone mass and their effects are mainly mediated via estrogen receptor (ER)α. Central ERα exerts an inhibitory role on…”
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Central effects of estradiol in the regulation of food intake, body weight, and adiposity by Brown, L.M., Clegg, D.J.

“…In recent years, obesity and its associated health disorders and costs have increased. Accumulation of adipose tissue, or fat, in the intra-abdominal adipose…”
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Enhanced anorexigenic signaling in lean obesity resistant syndecan-3 null mice by Zheng, Q, Zhu, J, Shanabrough, M, Borok, E, Benoit, S.C, Horvath, T.L, Clegg, D.J, Reizes, O

“…Abstract Obesity is associated with increased risk of diabetes, cardiovascular disease and several types of cancers. The hypothalamus is a region of the brain…”
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Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus by Irani, B.G, Donato, J, Olson, D.P, Lowell, B.B, Sacktor, T.C, Reyland, M.E, Tolson, K.P, Zinn, A.R, Ueta, Y, Sakata, I, Zigman, J.M, Elias, C.F, Clegg, D.J

“…Abstract PKC-theta (PKC-θ), a member of the novel protein kinase C family (nPKC), regulates a wide variety of functions in the periphery. However, its presence…”
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Combined Blockade of Both μ- and κ-Opioid Receptors Prevents the Acute Orexigenic Action of Agouti-Related Protein by Brugman, S, Clegg, D. J, Woods, S. C, Seeley, R. J

“…Agouti-related protein (AgRP) is an endogenous antagonist at the melanocortin 3 and 4 receptor in the hypothalamus. Central administration of AgRP produces a…”
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Influence of fatty acid diets on gene expression in rat mammary epithelial cells by Medvedovic, M, Gear, R, Freudenberg, J. M, Schneider, J, Bornschein, R, Yan, M, Mistry, M. J, Hendrix, H, Karyala, S, Halbleib, D, Heffelfinger, S, Clegg, D. J, Anderson, M. W

“…Departments of 1 Cancer and Cell Biology and 2 Environmental Health, University of Cincinnati, Cincinnati, Ohio; 3 Department of Internal Medicine, University…”
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Estrogen, astrocytes and the neuroendocrine control of metabolism by Fuente-Martin, E., Garcia-Caceres, C., Morselli, E., Clegg, D. J., Chowen, J. A., Finan, B., Brinton, R. D., Tschöp, M. H.

“…Obesity, and its associated comorbidities such as type 2 diabetes, cardiovascular diseases, and certain cancers, represent major health challenges…”
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The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins by Benoit, Stephen C, Air, Ellen L, Coolen, Lique M, Strauss, Richelle, Jackman, Alana, Clegg, Deborah J, Seeley, Randy J, Woods, Stephen C

“…Like leptin, the pancreatic hormone insulin is an important adiposity signal to the brain. We report that the hypothalamic melanocortin system is an important…”
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Dosing via gavage or diet for reproduction studies: a pilot study using two fat-soluble compounds—hexachlorobenzene and Aroclor 1254 by Arnold, D.L, Bryce, F.R, Clegg, D.J, Cherry, W, Tanner, J.R, Hayward, S

“…The choice of a dosing route for in vivo toxicological tests is often dictated by practical constraints. Reproduction studies are particularly challenging in…”
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Consumption of a high-fat diet alters the homeostatic regulation of energy balance by Woods, Stephen C., D'Alessio, David A., Tso, Patrick, Rushing, Paul A., Clegg, Deborah J., Benoit, Stephen C., Gotoh, Koro, Liu, Min, Seeley, Randy J.

“…Humans in many countries are currently experiencing what has been called an epidemic of obesity. That is, the average body weight (and amount of fat stored in…”
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critical role of the melanocortin system in the control of energy balance by Seeley, R.J, Drazen, D.L, Clegg, D.J

“…Animals have developed highly adaptive and redundant mechanisms to maintain energy balance by matching caloric intake to caloric expenditure. Recent evidence…”
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Charles River Sprague Dawley rats lack early age-dependent susceptibility to DMBA-induced mammary carcinogenesis by Gear, R B, Yan, M, Schneider, J, Succop, P, Heffelfinger, S C, Clegg, D J

“…Developmental stages of mammary glands influence their susceptibility to initiating events related to carcinogenesis. The "window of susceptibility" to mammary…”
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The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides by Benoit, Stephen C., Clegg, Deborah J., Woods, Stephen C., Seeley, Randy J.

“…The ingestion of foods is comprised of two distinct phases of behavior: appetitive and consummatory. While most food intake paradigms include both phases, the…”
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Classification of carcinogens: polemics, pedantics, or progress? by Clayson, D B, Clegg, D J

“…Rodent carcinogens may, for physiological or other reasons, induce cancer by a variety of mechanisms which vary in their ability to affect humans. While the…”
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