Late ovarian relapse of TEL/AML1 positive ALL confirming that TEL deletion is a secondary event in leukemogenesis

We describe here a late extramedullary ovarian relapse in an 18-year-old female who was diagnosed with hypotetraploid cell acute lymphoblastic leukaemia (cALL) at the age of 6. At both occurrences of the disease cells were analyzed by morphology, immunophenotyping, cytogenetics and molecular methods...

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Bibliographic Details
Published in:	Leukemia research Vol. 29; no. 9; pp. 1089 - 1094
Main Authors:	Ly-Sunnaram, Beatrice, Henry, Catherine, Gandemer, Virginie, Mee, Franseza Le, Burtin, Florence, Blayau, Martine, Cayuela, Jean-Michel, Oster, Magalie, Clech, Philippe, Rambeau, Marc, Marie, Celine, Pampin, Cecilia, Edan, Christine, Gall, Edouard Le, Goasguen, Jean E.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-09-2005
Subjects:	Adolescent ALL Core Binding Factor Alpha 2 Subunit Female Gene Deletion Humans Immunophenotyping In Situ Hybridization, Fluorescence Oncogene Proteins, Fusion - genetics Ovarian Neoplasms - secondary Ovarian tumor Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Recurrence Relapse Reverse Transcriptase Polymerase Chain Reaction TEL TEL/AML1 Tetraploidy Tetraploidy ALL Relapse TEL TEL/AML1 Ovarian tumor
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Summary:	We describe here a late extramedullary ovarian relapse in an 18-year-old female who was diagnosed with hypotetraploid cell acute lymphoblastic leukaemia (cALL) at the age of 6. At both occurrences of the disease cells were analyzed by morphology, immunophenotyping, cytogenetics and molecular methods. TEL/AML1 was detected by RT-PCR and FISH analysis in both events. We demonstrated, using detection of IGH/TCR rearrangements and TEL/AML1 breakpoints sequencing that the cells were clonally related. Moreover, interphasic FISH using TEL and AML1 probes showed the loss of a second TEL at the time of relapse. This observation confirms that TEL/AML1 alone is not sufficient to trigger ALL and that TEL deletion is a secondary event in leukemogenesis. To our knowledge, it is the first complete description of extramedullary ALL relapse combining all methodologies.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2004.11.027