Search Results - "Cleal, Kez"

Telomere Length Dynamics and the Evolution of Cancer Genome Architecture by Cleal, Kez, Norris, Kevin, Baird, Duncan

“…Telomeres are progressively eroded during repeated rounds of cell division due to the end replication problem but also undergo additional more substantial…”
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High-throughput STELA provides a rapid test for the diagnosis of telomere biology disorders by Norris, Kevin, Walne, Amanda J., Ponsford, Mark J., Cleal, Kez, Grimstead, Julia W., Ellison, Alicia, Alnajar, Jenna, Dokal, Inderjeet, Vulliamy, Tom, Baird, Duncan M.

“…Telomere biology disorders are complex clinical conditions that arise due to mutations in genes required for telomere maintenance. Telomere length has been…”
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Telomere fusions associate with coding sequence and copy number alterations in CLL by Escudero, Laura, Cleal, Kez, Ashelford, Kevin, Fegan, Chris, Pepper, Chris, Liddiard, Kate, Baird, Duncan M.

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ATRX modulates the escape from a telomere crisis by Geiller, Helene E B, Harvey, Adam, Jones, Rhiannon E, Grimstead, Julia W, Cleal, Kez, Hendrickson, Eric A, Baird, Duncan M

“…Telomerase activity is the principal telomere maintenance mechanism in human cancers, however 15% of cancers utilise a recombination-based mechanism referred…”
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DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase by Liddiard, Kate, Ruis, Brian, Kan, Yinan, Cleal, Kez, Ashelford, Kevin E, Hendrickson, Eric A, Baird, Duncan M

“…Abstract Fusion of critically short or damaged telomeres is associated with the genomic rearrangements that support malignant transformation. We have…”
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Endocytosis, intracellular traffic and fate of cell penetrating peptide based conjugates and nanoparticles by Cleal, Kez, He, Lin, Watson, Peter D, Jones, Arwyn T

“…The insides of cells can be viewed as a treasure trove of targets for therapeutic intervention of diseases or as deposits for contrasting agents. Increasingly…”
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Dysgu: efficient structural variant calling using short or long reads by Cleal, Kez, Baird, Duncan M

“…Structural variation (SV) plays a fundamental role in genome evolution and can underlie inherited or acquired diseases such as cancer. Long-read sequencing…”
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Catastrophic Endgames: Emerging Mechanisms of Telomere-Driven Genomic Instability by Cleal, Kez, Baird, Duncan M.

“…When cells progress to malignancy, they must overcome a final telomere-mediated proliferative lifespan barrier called replicative crisis. Crisis is…”
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Chromothripsis during telomere crisis is independent of NHEJ, and consistent with a replicative origin by Cleal, Kez, Jones, Rhiannon E, Grimstead, Julia W, Hendrickson, Eric A, Baird, Duncan M

“…Telomere erosion, dysfunction, and fusion can lead to a state of cellular crisis characterized by large-scale genome instability. We investigated the impact of…”
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Tracking telomere fusions through crisis reveals conflict between DNA transcription and the DNA damage response by Liddiard, Kate, Grimstead, Julia W, Cleal, Kez, Evans, Anna, Baird, Duncan M

“…Identifying attributes that distinguish pre-malignant from senescent cells provides opportunities for targeted disease eradication and revival of anti-tumour…”
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POLQ suppresses genome instability and alterations in DNA repeat tract lengths by Liddiard, Kate, Aston-Evans, Alys N, Cleal, Kez, Hendrickson, Eric A, Baird, Duncan M

“…DNA polymerase theta (POLQ) is a principal component of the alternative non-homologous end-joining (ANHEJ) DNA repair pathway that ligates DNA double-strand…”
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Exploring the use of quantum dots as quantitative model delivery agents for small molecules, peptides and proteins by Cleal, Kez

“…Progress in the biological sciences is leading to the characterization of a wide range of disease processes in molecular detail. However overriding or…”
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