Search Results - "Clayton, Tim C."

Long-Term Follow-Up of Elective Chronic Total Coronary Occlusion Angioplasty by George, Sudhakar, MD, Cockburn, James, MD, Clayton, Tim C., MSc, Ludman, Peter, MD, Cotton, James, MD, Spratt, James, MA, Redwood, Simon, MD, de Belder, Mark, MD, de Belder, Adam, MD, Hill, Jonathan, MA, Hoye, Angela, MBChB, PhD, Palmer, Nick, MD, Rathore, Sudhir, MD, Gershlick, Anthony, MB BS, Di Mario, Carlo, MD, PhD, Hildick-Smith, David, MD

“…Abstract Background Chronic total occlusion (CTO) is common, being reported in 18% to 30% of patients undergoing coronary angiography. Percutaneous coronary…”
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Coronary artery bypass surgery compared with percutaneous coronary interventions for multivessel disease: a collaborative analysis of individual patient data from ten randomised trials by Hlatky, Mark A, Prof, Boothroyd, Derek B, PhD, Bravata, Dena M, MD, Boersma, Eric, Prof, Booth, Jean, MS, Brooks, Maria M, PhD, Carrié, Didier, MD, Clayton, Tim C, MSc, Danchin, Nicolas, MD, Flather, Marcus, FRCP, Hamm, Christian W, MD, Hueb, Whady A, Prof, Kähler, Jan, MD, Kelsey, Sheryl F, Prof, King, Spencer B, MD, Kosinski, Andrzej S, PhD, Lopes, Neuza, MD, McDonald, Kathryn M, MM, Rodriguez, Alfredo, MD, Serruys, Patrick, Prof, Sigwart, Ulrich, Prof, Stables, Rodney H, DM, Owens, Douglas K, Prof, Pocock, Stuart J, Prof

“…Summary Background Coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) are alternative treatments for multivessel coronary…”
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Impact of major bleeding and blood transfusions after cardiac surgery: Analysis from the Acute Catheterization and Urgent Intervention Triage strategY (ACUITY) trial by Stone, Gregg W., MD, Clayton, Tim C., MSc, Mehran, Roxana, MD, Dangas, George, MD, Parise, Helen, ScD, Fahy, Martin, MSc, Pocock, Stuart J., PhD

“…Background Prior retrospective studies have identified a relationship between bleeding after cardiac surgery and subsequent mortality. Whether this is…”
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Survival plots of time-to-event outcomes in clinical trials: good practice and pitfalls by Pocock, Stuart J, Clayton, Tim C, Altman, Douglas G

“…Survival plots of time-to-event data are a key component for reporting results of many clinical trials (and cohort studies). However, mistakes and distortions…”
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Seven-year outcome in the RITA-2 trial: coronary angioplasty versus medical therapy by Henderson, Robert A., Pocock, Stuart J., Clayton, Tim C., Knight, Rosemary, Fox, Keith A.A., Julian, Desmond G., Chamberlain, Douglas A.

“…This study was designed to compare the long-term consequences of percutaneous transluminal coronary angioplasty (PTCA) and continued medical treatment. The…”
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Individualizing treatment choices using quantitative methods by Pocock, Stuart J., PhD, Stone, Gregg W., MD, Mehran, Roxana, MD, Clayton, Tim C., MSc

“…[...]the absolute treatment benefit will be markedly less in low-risk patients, which has implications for whom the new treatment is warranted. [...]Salisbury…”
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Challenging Issues in Clinical Trial Design by Pocock, Stuart J., PhD, Clayton, Tim C., MSc, Stone, Gregg W., MD

“…Abstract As a sequel to last week’s paper on the fundamentals of clinical trial design, this paper tackles related controversial issues: noninferiority trials,…”
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Design of Major Randomized Trials by Pocock, Stuart J., PhD, Clayton, Tim C., MSc, Stone, Gregg W., MD

“…Abstract This paper provides practical guidance on the fundamentals of design for major randomized controlled trials. Topics covered include the choice of…”
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The Effect of Age on Outcomes of Coronary Artery Bypass Surgery Compared With Balloon Angioplasty or Bare-Metal Stent Implantation Among Patients With Multivessel Coronary Disease by Flather, Marcus, MBBS, Rhee, June-Wha, MD, Boothroyd, Derek B., PhD, Boersma, Eric, PhD, Brooks, Maria Mori, PhD, Carrié, Didier, MD, PhD, Clayton, Tim C., MS, Danchin, Nicholas, MD, Hamm, Christian W., MD, Hueb, Whady A., MD, King, Spencer B., MD, Pocock, Stuart J., PhD, Rodriguez, Alfredo E., MD, PhD, Serruys, Patrick, MD, Sigwart, Ulrich, MD, Stables, Rodney H., MD, Hlatky, Mark A., MD

“…Objectives This study sought to assess whether patient age modifies the comparative effectiveness of coronary artery bypass graft (CABG) surgery and…”
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Usefulness of the Admission Electrocardiogram to Predict Long-Term Outcomes After Non-ST-Elevation Acute Coronary Syndrome (from the FRISC II, ICTUS, and RITA-3 [FIR] Trials) by Damman, Peter, MD, Holmvang, Lene, MD, PhD, Tijssen, Jan G.P., PhD, Lagerqvist, Bo, MD, PhD, Clayton, Tim C., BSc, MSc, Pocock, Stuart J., BSc, MSc, PhD, Windhausen, Fons, MD, PhD, Hirsch, Alexander, MD, PhD, Fox, Keith A.A., BSc, MB, ChB, Wallentin, Lars, MD, PhD, de Winter, Robbert J., MD, PhD

“…The aim of this study was to evaluate the independent prognostic value of qualitative and quantitative admission electrocardiographic (ECG) analysis regarding…”
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Long-Term Follow-Up of Elective Chronic Total Coronary Occlusion Angioplasty: Analysis From the U.K. Central Cardiac Audit Database by GEORGE, Sudhakar, COCKBURN, James, HOYE, Angela, PALMER, Nick, RATHORE, Sudhir, GERSHLICK, Anthony, DI MARIO, Carlo, HILDICK-SMITH, David, CLAYTON, Tim C, LUDMAN, Peter, COTTON, James, SPRATT, James, REDWOOD, Simon, DE BELDER, Mark, DE BELDER, Adam, HILL, Jonathan

“…Chronic total occlusion (CTO) is common, being reported in 18% to 30% of patients undergoing coronary angiography. Percutaneous coronary intervention (PCI) is…”
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Long-Term Impact of Acyclovir Suppressive Therapy on Genital and Plasma HIV RNA in Tanzanian Women: A Randomized Controlled Trial by Tanton, Clare, Weiss, Helen A., Rusizoka, Mary, LeGoff, Jerome, Changalucha, John, Baisley, Kathy, Mugeye, Kokugonza, Everett, Dean, Belec, Laurent, Clayton, Tim C., Ross, David A., Hayes, Richard J., Watson-Jones, Deborah

“…(See the editorial commentary by Baeten, on pages 1279–1281.) Background. Herpes simplex virus (HSV) suppressive therapy reduces genital and plasma human…”
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Morbidity and Mortality in South African Gold Miners: Impact of Untreated Disease Due to Human Immunodeficiency Virus by Corbett, Elizabeth L., Churchyard, Gavin J., Charalambos, Salome, Samb, Badara, Moloi, Vicky, Clayton, Tim C., Grant, Alison D., Murray, Jill, Hayes, Richard J., De Cock, Kevin M.

“…A cohort of 1792 human immunodeficiency virus (HIV)—positive and 2970 HIV-negative South African miners was observed for 12 months starting in February 1998…”
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The effect of internal thoracic artery grafts on long-term clinical outcomes after coronary bypass surgery by Hlatky, Mark A., MD, Shilane, David, PhD, Boothroyd, Derek B., PhD, Boersma, Eric, PhD, Brooks, Maria M., PhD, Carrié, Didier, MD, PhD, Clayton, Tim C., MSc, Danchin, Nicolas, MD, Flather, Marcus, MBBS, FRCP, Hamm, Christian W., MD, Hueb, Whady A., MD, Kahler, Jan, MD, Lopes, Neuza, MD, Pocock, Stuart J., PhD, Rodriguez, Alfredo, MD, PhD, Serruys, Patrick, MD, Sigwart, Ulrich, MD, Stables, Rodney H., MD

“…Objectives We sought to compare long-term outcomes after coronary bypass surgery with and without an internal thoracic artery graft. Methods We analyzed…”
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Design of Major Randomized Trials: Part 3 of a 4-Part Series on Statistics for Clinical Trials by Pocock, Stuart J, Clayton, Tim C, Stone, Gregg W

“…This paper provides practical guidance on the fundamentals of design for major randomized controlled trials. Topics covered include the choice of patients,…”
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Long-Term Outcome of a Routine Versus Selective Invasive Strategy in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome: A Meta-Analysis of Individual Patient Data by FOX, Keith A. A, CLAYTON, Tim C, DAMMAN, Peter, POCOCK, Stuart J, DE WINTER, Robbert J, TIJSSEN, Jan G. P, LAGERQVIST, Bo, WALLENTIN, Lars

“…This study was designed to determine: 1) whether a routine invasive (RI) strategy reduces the long-term frequency of cardiovascular death or nonfatal…”
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Randomized Trial of Simple Versus Complex Drug-Eluting Stenting for Bifurcation Lesions: The British Bifurcation Coronary Study: Old, New, and Evolving Strategies by HILDICK-SMITH, David, DE BELDER, Adam J, THOMAS, Martyn R, MACCARTHY, Philip A, BAUMBACH, Andreas, MULVIHILL, Niall T, HENDERSON, Robert A, REDWOOD, Simon R, STARKEY, Ian R, STABLES, Rodney H, COOTER, Nina, CURZEN, Nicholas P, CLAYTON, Tim C, OLDROYD, Keith G, BENNETT, Lorraine, HOLMBERG, Steve, COTTON, James M, GLENNON, Peter E

“…The optimal strategy for treating coronary bifurcation lesions remains a subject of debate. With bare-metal stents, single-stent approaches appear to be…”
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Challenging Issues in Clinical Trial Design: Part 4 of a 4-Part Series on Statistics for Clinical Trials by Pocock, Stuart J, Clayton, Tim C, Stone, Gregg W

“…As a sequel to last week's paper on the fundamentals of clinical trial design, this paper tackles related controversial issues: noninferiority trials, the…”
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An Invasive or Conservative Strategy in Patients With Diabetes Mellitus and Non–ST-Segment Elevation Acute Coronary Syndromes by O'Donoghue, Michelle L., MD, MPH, Vaidya, Ajay, MD, MPH, Afsal, Rizwan, MSc, Alfredsson, Joakim, MD, PhD, Boden, William E., MD, Braunwald, Eugene, MD, Cannon, Christopher P., MD, Clayton, Tim C., MSc, de Winter, Robbert J., MD, PhD, Fox, Keith A.A., MB ChB, Lagerqvist, Bo, MD, PhD, McCullough, Peter A., MD, MPH, Murphy, Sabina A., MPH, Spacek, Rudolf, MD, PhD, Swahn, Eva, MD, PhD, Windhausen, Fons, MD, Sabatine, Marc S., MD, MPH

“…Objectives The purpose of this study was to conduct a meta-analysis to examine an invasive or conservative strategy in diabetic versus nondiabetic patients…”
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Recent respiratory infection and risk of venous thromboembolism: case-control study through a general practice database by Clayton, Tim C, Gaskin, Marion, Meade, Tom W

“…Background The association between respiratory infection and risk of heart attacks and strokes is well established. However, less evidence exists for an…”
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