Search Results - "Clayton, Kevin A."

Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy by Clayton, Kevin A, Van Enoo, Alicia A, Ikezu, Tsuneya

“…Brain aging is central to late-onset Alzheimer's disease (LOAD), although the mechanisms by which it occurs at protein or cellular levels are not fully…”
Get full text

A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells by Varnum, Megan M., Clayton, Kevin A., Yoshii-Kitahara, Asuka, Yonemoto, Grant, Koro, Lacin, Ikezu, Seiko, Ikezu, Tsuneya

“…Triggering receptor expressed on myeloid cells 2 (TREM2) is a single transmembrane molecule uniquely expressed in microglia. TREM2 mutations are genetically…”
Get full text

Amyloid Plaque Deposition Accelerates Tau Propagation Via Activation of Microglia in a Humanized App Mouse Model by Clayton, Kevin A

“…Alzheimer’s disease is characterized by the formation of two major pathological hallmarks: amyloid plaques and neurofibrillary tangles. Although there have…”
Get full text