Search Results - "Clayton, Kevin"

Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy by Clayton, Kevin A, Van Enoo, Alicia A, Ikezu, Tsuneya

“…Brain aging is central to late-onset Alzheimer's disease (LOAD), although the mechanisms by which it occurs at protein or cellular levels are not fully…”
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Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model by Clayton, Kevin, Delpech, Jean Christophe, Herron, Shawn, Iwahara, Naotoshi, Ericsson, Maria, Saito, Takashi, Saido, Takaomi C, Ikezu, Seiko, Ikezu, Tsuneya

“…Recent studies suggest that microglia contribute to tau pathology progression in Alzheimer's disease. Amyloid plaque accumulation transforms microglia, the…”
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A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells by Varnum, Megan M., Clayton, Kevin A., Yoshii-Kitahara, Asuka, Yonemoto, Grant, Koro, Lacin, Ikezu, Seiko, Ikezu, Tsuneya

“…Triggering receptor expressed on myeloid cells 2 (TREM2) is a single transmembrane molecule uniquely expressed in microglia. TREM2 mutations are genetically…”
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Neuronal pentraxin 1 negatively regulates excitatory synapse density and synaptic plasticity by Figueiro-Silva, Joana, Gruart, Agnès, Clayton, Kevin Bernard, Podlesniy, Petar, Abad, Maria Alba, Gasull, Xavier, Delgado-García, José María, Trullas, Ramon

“…In mature neurons, the number of synapses is determined by a neuronal activity-dependent dynamic equilibrium between positive and negative regulatory factors…”
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Clinical Applications of Biomedical Microdevices for Controlled Drug Delivery by Gurman, Pablo, MD, Miranda, Oscar R., PhD, Clayton, Kevin, BS, Rosen, Yitzhak, MD, Elman, Noel M., PhD

“…Abstract Miniaturization of devices to micrometer and nanometer scales, combined with the use of biocompatible and functional materials, has created new…”
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Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model by Clayton, Kevin, Delpech, Jean Christophe, Herron, Shawn, Iwahara, Naotoshi, Ericsson, Maria, Saito, Takashi, Saido, Takaomi C, Ikezu, Seiko, Ikezu, Tsuneya

“…An amendment to this paper has been published and can be accessed via the original article…”
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Community pharmacists’ recommendations for natural products for stress in Melbourne, Australia: a simulated patient study by Clayton, Kevin, Luxford, Yoni, Colaci, Joshua, Hasan, Meral, Miltiadou, Rebecca, Novikova, Daria, Vlahopoulos, Dean, Stupans, Ieva

“…Abstract Background: Community pharmacists are often the first health professional approached to provide treatment for health issues, including the important…”
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In situ measurement of tritium permeation through stainless steel by Luscher, Walter G., Senor, David J., Clayton, Kevin K., Longhurst, Glen R.

“…► In situ tritium permeation measurements collected over broad pressure range. ► Test conditions relevant to 316 SS in commercial light water reactors. ►…”
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NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics by Clayton, Kevin B, Podlesniy, Petar, Figueiro-Silva, Joana, López-Doménech, Guillermo, Benitez, Lluis, Enguita, Marta, Abad, Maria A, Soriano, Eduardo, Trullas, Ramon

“…In cultured cerebellar granule neurons, low neuronal activity triggers the intrinsic program of apoptosis, which requires protein synthesis-dependent BAX…”
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In-reactor oxidation of zircaloy-4 under low water vapor pressures by Luscher, Walter G., Senor, David J., Clayton, Kevin K., Longhurst, Glen R.

“…•Observed oxidation of Zircaloy-4 under low water vapor pressure.•Detailed description of in-reactor test assembly.•Oxidation and hydrogen absorption…”
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Differential effects of GDF5 on the medial and lateral rat ventral mesencephalon by Clayton, Kevin B., Sullivan, Aideen M.

“…Growth/differentiation factor 5 (GDF5) is a member of the transforming growth factor-β (TGF-β) superfamily that has potent neurotrophic and protective effects…”
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Attitudes and Knowledge of Community Pharmacists Toward Complementary and Alternative Medicine: A Narrative Review by Clayton, Kevin, Luxford, Yoni, Stupans, Ieva

“…The use of complementary and alternative medicine (CAM) in Australia is widespread, and self-treatment with CAM often occurs. Community pharmacies are a major…”
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CSF1R inhibitor abrogates tau propagation exacerbated in APP NL‐G‐F knock‐in mice but enhances fibrillar beta‐amyloidosis and dystrophic neurite formation in the brain: Development of new models and analysis methods/neuroinflammation by Clayton, Kevin, Delpech, Jean Christophe, Herron, Shawn, Saito, Takashi, Ikezu, Seiko, Saido, Takaomi C., Ikezu, Tsuneya

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CSF1R inhibitor abrogates tau propagation exacerbated in APPNL‐G‐F knock‐in mice but enhances fibrillar beta‐amyloidosis and dystrophic neurite formation in the brain by Clayton, Kevin, Delpech, Jean Christophe, Herron, Shawn, Saito, Takashi, Ikezu, Seiko, Saido, Takaomi C., Ikezu, Tsuneya

“…Background Microglia are the primary innate immune cells in the brain. They can phagocytose apoptotic neurons and dystrophic neurites containing aggregated and…”
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Decision-making factors of pharmacy customers purchasing over-the-counter complementary and alternative medicine for stress by Clayton, Kevin, Luxford, Yoni, Stupans, Ieva

“…The use of complementary and alternative medicine (CAM) is increasing and some of this CAM is purchased as self-directed treatment for stress, a practice that…”
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Amyloid Plaque Deposition Accelerates Tau Propagation Via Activation of Microglia in a Humanized App Mouse Model by Clayton, Kevin A

“…Alzheimer’s disease is characterized by the formation of two major pathological hallmarks: amyloid plaques and neurofibrillary tangles. Although there have…”
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In-Reactor Oxidation of Zircaloy-4 Under Low Water Vapor Pressures by Luscher, Walter G., Senor, David J., Clayton, Kevin, Longhurst, Glen

“…Complementary in- and ex-reactor oxidation tests have been performed to evaluate the oxidation and hydrogen absorption performance of Zircaloy-4 (Zr-4) under…”
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Restriction of Glioma Progression and Mesenchymal Characteristics by Angiomotin-Like 1 by Lange, Kevin Clayton

“…Angiomotin-like 1 (AmotL1) serves as a scaffold for protein complexes that promote cell polarity and HIPPO signaling to enable their suppression of oncogenic…”
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Rapid Reconstitution Packages (RRPs) implemented by integration of computational fluid dynamics (CFD) and 3D printed microfluidics by Chi, Albert, Curi, Sebastian, Clayton, Kevin, Luciano, David, Klauber, Kameron, Alexander-Katz, Alfredo, D’hers, Sebastian, Elman, Noel M.

“…Rapid Reconstitution Packages (RRPs) are portable platforms that integrate microfluidics for rapid reconstitution of lyophilized drugs. Rapid reconstitution of…”
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In situ measurement of tritium permeation through stainless steel by Walter G. Luscher, David J. Senor, Kevin K. Clayton, Glen R. Longhurst

“…The TMIST-2 irradiation experiment was conducted in the Advanced Test Reactor at Idaho National Laboratory to evaluate tritium permeation through Type 316…”
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