Search Results - "Clayton, D. G."

Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation by Khan, J C, Thurlby, D A, Shahid, H, Clayton, D G, Yates, J R W, Bradley, M, Moore, A T, Bird, A C

“…Background/aims: There is evidence that smoking is a risk factor for age related macular degeneration (AMD). However, not all studies have demonstrated this…”
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Design and Analysis of Admixture Mapping Studies by Hoggart, C.J., Shriver, M.D., Kittles, R.A., Clayton, D.G., McKeigue, P.M.

“…Admixture between populations originating on different continents can be exploited to detect disease susceptibility loci at which risk alleles are distributed…”
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Approximate Inference in Generalized Linear Mixed Models by Breslow, N. E., Clayton, D. G.

“…Statistical approaches to overdispersion, correlated errors, shrinkage estimation, and smoothing of regression relationships may be encompassed within the…”
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A Unified Stepwise Regression Procedure for Evaluating the Relative Effects of Polymorphisms within a Gene Using Case/Control or Family Data: Application to HLA in Type 1 Diabetes by Cordell, Heather J., Clayton, David G.

“…A stepwise logistic-regression procedure is proposed for evaluation of the relative importance of variants at different sites within a small genetic region. By…”
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Age related macular degeneration and sun exposure, iris colour, and skin sensitivity to sunlight by Khan, J C, Shahid, H, Thurlby, D A, Bradley, M, Clayton, D G, Moore, A T, Bird, A C, Yates, J R W

“…Background/aim: It has been suggested that sun exposure may be a risk factor for age related macular degeneration (AMD) and that skin sensitivity to sunlight…”
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Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design by BARRATT, B. J., PAYNE, F., RANCE, H. E., NUTLAND, S., TODD, J. A., CLAYTON, D. G.

“…Genotyping costs still preclude analysis of a comprehensive SNP map in thousands of individual subjects in the search for disease susceptibility loci. Allele…”
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Spatial correlation in ecological analysis by Clayton, D G, Bernardinelli, L, Montomoli, C

“…This paper presents a statistical approach, originally developed for mapping disease risk, to ecological regression analysis in the presence of spatial…”
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Exercise in leisure time: coronary attack and death rates by Morris, J N, Clayton, D G, Everitt, M G, Semmence, A M, Burgess, E H

“…Nine thousand three hundred and seventy six male civil servants, aged 45-64 at entry, with no clinical history of coronary heart disease, were followed for a…”
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A Monte Carlo Method for Bayesian Inference in Frailty Models by Clayton, David G.

“…Many analyses in epidemiological and prognostic studies and in studies of event history data require methods that allow for unobserved covariates or…”
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Fine genetic mapping using haplotype analysis and the missing data problem by CHIANO, M. N., CLAYTON, D. G.

“…The genetic basis of many human diseases, especially those with substantial genetic determinants, has been identified. Notable amongst others are cystic…”
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Modelling Complexity: Applications of Gibbs Sampling in Medicine by Gilks, W. R., Clayton, D. G., Spiegelhalter, D. J., Best, N. G., McNeil, A. J.

“…We review applications of Gibbs sampling in medicine, involving longitudinal, spatial, covariate measurement and survival models. Applications in immunology,…”
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Association between the ancestral haplotype HLA A30B18DR3 and multiple sclerosis in central Sardinia by Bitti, P.P., Murgia, B.S., Ticca, A., Ferrai, R., Musu, L., Piras, M.L., Puledda, E., Campo, S., Durando, S., Montomoli, C., Clayton, D.G., Mander, A.P., Bernardinelli, L.

“…Association and linkage studies have established the importance of the major histocompatibility complex (MHC) in the susceptibility for multiple sclerosis…”
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The Australian Incident Monitoring Study in Intensive Care : AIMS-ICU. The development and evaluation of an incident reporting system in intensive care by BECKMANN, U, WEST, L. F, GROOMBRIDGE, G. J, BALDWIN, I, HART, G. K, CLAYTON, D. G, WEBB, R. K, RUNCIMAN, W. B

“…Intensive care units are complex, dynamic patient management environments. Incidents and accidents can be caused by human error, by problems inherent in…”
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Control of Confounding of Genetic Associations in Stratified Populations by Hoggart, Clive J., Parra, Esteban J., Shriver, Mark D., Bonilla, Carolina, Kittles, Rick A., Clayton, David G., McKeigue, Paul M.

“…To control for hidden population stratification in genetic-association studies, statistical methods that use marker genotype data to infer population structure…”
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Quality of digital x-ray images by Clayton Jones, D. G.

“…Direct comparison of a number of views on conventional films, which can be displayed simultaneously, readily positioned and moved about on a light box,…”
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Haplotype tagging for the identification of common disease genes by Todd, John A, Johnson, Gillian C.L, Esposito, Laura, Barratt, Bryan J, Smith, Annabel N, Heward, Joanne, Di Genova, Gianfranco, Ueda, Hironori, Cordell, Heather J, Eaves, Iain A, Dudbridge, Frank, Twells, Rebecca C.J, Payne, Felicity, Hughes, Wil, Nutland, Sarah, Stevens, Helen, Carr, Phillipa, Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Gough, Stephen C.L, Clayton, David G

“…Genome-wide linkage disequilibrium (LD) mapping of common disease genes could be more powerful than linkage analysis if the appropriate density of polymorphic…”
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Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene by MAIER, L. M, TWELLS, R. C. J, WALKER, N. M, BURREN, O. S, NUTLAND, S, RANCE, H, TUOMILEHTO-WOLF, E, TUOMILEHTO, J, GUJA, C, IONESCU-TIRGOVISTE, C, UNDLIEN, D. E, RØNNINGEN, K. S, HOWSON, J. M. M, CUCCA, F, TODD, J. A, LAM, A. C, CLAYTON, D. G, SMYTH, D. J, SAVAGE, D, CARSON, D, PATTERSON, C. C, SMINK, L. J

“…Variations in the interleukin 4 receptor A (IL4RA) gene have been reported to be associated with atopy, asthma, and allergy, which may occur less frequently in…”
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Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects by Cordell, Heather J., Barratt, Bryan J., Clayton, David G.

“…Estimation and testing of genetic effects (genotype relative risks) are often performed conditionally on parental genotypes, using data from case‐parent trios…”
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Betting odds and genetic associations by Thomas, Duncan C, Clayton, David G

“…Genet Med 2002;4:45 61.(7) Hsu JC. Multiple comparisons: theory and methods. London (UK): Chapman and Hall; 1996.(8) Cole P. The evolving case-control study. J…”
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Calcaneal ultrasound attenuation in an elderly population : Measurement position and relationships with body size and past fractures by DONALDSON, M. M. K, MCGROTHER, C. W, CLAYTON, D. G, CLARKE, M, OSBORNE, D

“…This study demonstrates, the relationship between past fracture, body size and broadband ultrasound attenuation (BUA) and investigates two sites of BUA…”
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