Ciprofloxacin-Induced Bullae of the Lower Extremity: A Case of a Fixed Drug Reaction

Cutaneous adverse drug reactions make up 1% to 2% of all adverse drug reactions. From these adverse cutaneous drug reactions, 16% to 21% can be categorized as fixed drug reactions (FDR). Fixed drug reactions may show diverse morphology including but not limited to the following: dermatitis, Stevens-...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of the American Podiatric Medical Association Vol. 109; no. 2; pp. 155 - 158
Main Authors:	Mollica, Anthony J, Mollica, Albert J, Grant, Elaine, Malik, Ali, Claydon, Marc
Format:	Journal Article
Language:	English
Published:	United States 01-03-2019
Subjects:	Anti-Bacterial Agents - adverse effects Blister - chemically induced Blister - pathology Blister - therapy Ciprofloxacin - adverse effects Drug-Related Side Effects and Adverse Reactions - etiology Drug-Related Side Effects and Adverse Reactions - pathology Drug-Related Side Effects and Adverse Reactions - therapy Foot Hand Humans Male Middle Aged
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Cutaneous adverse drug reactions make up 1% to 2% of all adverse drug reactions. From these adverse cutaneous drug reactions, 16% to 21% can be categorized as fixed drug reactions (FDR). Fixed drug reactions may show diverse morphology including but not limited to the following: dermatitis, Stevens-Johnson syndrome, urticaria, morbilliform exanthema, hypersensitivity syndrome, pigmentary changes, acute generalized exanthematous pustulosis, photosensitivity, and vasculitis. An FDR will occur at the same site because of repeated exposure to the offending agent, causing a corresponding immune reaction. There are many drugs that can cause an FDR, such as analgesics, antibiotics, muscle relaxants, and anticonvulsants. The antibiotic ciprofloxacin has been shown to be a cause of cutaneous adverse drug reactions; however, the fixed drug reaction bullous variant is rare. This case study was published to demonstrate a rare adverse side effect to a commonly used antibiotic in podiatric medicine.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	8750-7315 1930-8264
DOI:	10.7547/17-088