Search Results - "Claycomb, Julie M."

Ancient Endo-siRNA Pathways Reveal New Tricks by Claycomb, Julie M.

“…Endogenously produced small interfering RNAs (endo-siRNAs, 18–30 nucleotides) play a key role in gene regulatory pathways, guiding Argonaute effector proteins…”
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Protection of Germline Gene Expression by the C. elegans Argonaute CSR-1 by Wedeles, Christopher J., Wu, Monica Z., Claycomb, Julie M.

“…In Caenorhabditis elegans, the Piwi-interacting small RNA (piRNA)-mediated germline surveillance system encodes more than 30,000 unique 21-nucleotide piRNAs,…”
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Connecting the Dots: Linking Caenorhabditis elegans Small RNA Pathways and Germ Granules by Sundby, Adam E., Molnar, Ruxandra I., Claycomb, Julie M.

“…Germ granules are non-membrane bound, phase-separated organelles, composed of RNAs and proteins. Germ granules are present only within the germ cells of…”
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A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions by Seroussi, Uri, Lugowski, Andrew, Wadi, Lina, Lao, Robert X, Willis, Alexandra R, Zhao, Winnie, Sundby, Adam E, Charlesworth, Amanda G, Reinke, Aaron W, Claycomb, Julie M

“…Argonaute (AGO) proteins associate with small RNAs to direct their effector function on complementary transcripts. The nematode contains an expanded family of…”
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Distinct Argonaute-Mediated 22G-RNA Pathways Direct Genome Surveillance in the C. elegans Germline by Gu, Weifeng, Shirayama, Masaki, Conte, Darryl, Vasale, Jessica, Batista, Pedro J., Claycomb, Julie M., Moresco, James J., Youngman, Elaine M., Keys, Jennifer, Stoltz, Matthew J., Chen, Chun-Chieh G., Chaves, Daniel A., Duan, Shenghua, Kasschau, Kristin D., Fahlgren, Noah, Yates, John R., Mitani, Shohei, Carrington, James C., Mello, Craig C.

“…Endogenous small RNAs (endo-siRNAs) interact with Argonaute (AGO) proteins to mediate sequence-specific regulation of diverse biological processes. Here, we…”
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The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation by Claycomb, Julie M., Batista, Pedro J., Pang, Ka Ming, Gu, Weifeng, Vasale, Jessica J., van Wolfswinkel, Josien C., Chaves, Daniel A., Shirayama, Masaki, Mitani, Shohei, Ketting, René F., Conte, Darryl, Mello, Craig C.

“…RNAi-related pathways regulate diverse processes, from developmental timing to transposon silencing. Here, we show that in C. elegans the Argonaute CSR-1, the…”
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Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans by Conine, Colin C, Batista, Pedro J, Gu, Weifeng, Claycomb, Julie M, Chaves, Daniel A, Shirayama, Masaki, Mello, Craig C

“…Gametogenesis is a thermosensitive process in numerous metazoans, ranging from worms to man. In Caenorhabditis elegans, a variety of RNA-binding proteins that…”
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Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility by Charlesworth, Amanda G, Seroussi, Uri, Lehrbach, Nicolas J, Renaud, Mathias S, Sundby, Adam E, Molnar, Ruxandra I, Lao, Robert X, Willis, Alexandra R, Woock, Jenna R, Aber, Matthew J, Diao, Annette J, Reinke, Aaron W, Ruvkun, Gary, Claycomb, Julie M

“…Abstract The Caenorhabditis elegans genome encodes nineteen functional Argonaute proteins that use 22G-RNAs, 26G-RNAs, miRNAs or piRNAs to regulate target…”
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PRG-1 and 21U-RNAs Interact to Form the piRNA Complex Required for Fertility in C. elegans by Batista, Pedro J., Ruby, J. Graham, Claycomb, Julie M., Chiang, Rosaria, Fahlgren, Noah, Kasschau, Kristin D., Chaves, Daniel A., Gu, Weifeng, Vasale, Jessica J., Duan, Shenghua, Conte, Darryl, Luo, Shujun, Schroth, Gary P., Carrington, James C., Bartel, David P., Mello, Craig C.

“…In metazoans, Piwi-related Argonaute proteins have been linked to germline maintenance, and to a class of germline-enriched small RNAs termed piRNAs. Here we…”
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Emerging from the Clouds: Vasa Helicase Sheds Light on piRNA Amplification by Claycomb, Julie M.

“…Reporting in a recent study in Cell, Xiol and colleagues (2014) identify the conserved DEAD box helicase Vasa as a platform for secondary Piwi-interacting RNA…”
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From early lessons to new frontiers: the worm as a treasure trove of small RNA biology by Youngman, Elaine M, Claycomb, Julie M

“…In the past 20 years, the tiny soil nematode Caenorhabditis elegans has provided critical insights into our understanding of the breadth of small RNA-mediated…”
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Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing by Garcia, Bianca, Lee, Jooyoung, Edraki, Alireza, Hidalgo-Reyes, Yurima, Erwood, Steven, Mir, Aamir, Trost, Chantel N., Seroussi, Uri, Stanley, Sabrina Y., Cohn, Ronald D., Claycomb, Julie M., Sontheimer, Erik J., Maxwell, Karen L., Davidson, Alan R.

“…CRISPR-Cas9 systems provide powerful tools for genome editing. However, optimal employment of this technology will require control of Cas9 activity so that the…”
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CDE-1 Affects Chromosome Segregation through Uridylation of CSR-1-Bound siRNAs by van Wolfswinkel, Josien C., Claycomb, Julie M., Batista, Pedro J., Mello, Craig C., Berezikov, Eugene, Ketting, René F.

“…We have studied the function of a conserved germline-specific nucleotidyltransferase protein, CDE-1, in RNAi and chromosome segregation in C. elegans. CDE-1…”
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Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway by Vasale, Jessica J, Gu, Weifeng, Thivierge, Caroline, Batista, Pedro J, Claycomb, Julie M, Youngman, Elaine M, Duchaine, Thomas F, Mello, Craig C, Conte, Darryl Jr

“…Argonaute (AGO) proteins interact with distinct classes of small RNAs to direct multiple regulatory outcomes. In many organisms, including plants, fungi, and…”
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The Smaug RNA-Binding Protein Is Essential for microRNA Synthesis During the Drosophila Maternal-to-Zygotic Transition by Luo, Hua, Li, Xiao, Claycomb, Julie M, Lipshitz, Howard D

“…Metazoan embryos undergo a maternal-to-zygotic transition (MZT) during which maternal gene products are eliminated and the zygotic genome becomes…”
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Comparative genomic analysis of upstream miRNA regulatory motifs in Caenorhabditis by Jovelin, Richard, Krizus, Aldis, Taghizada, Bakhtiyar, Gray, Jeremy C, Phillips, Patrick C, Claycomb, Julie M, Cutter, Asher D

“…MicroRNAs (miRNAs) comprise a class of short noncoding RNA molecules that play diverse developmental and physiological roles by controlling mRNA abundance and…”
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The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans by Davis, Gregory M, Tu, Shikui, Anderson, Joshua WT, Colson, Rhys N, Gunzburg, Menachem J, Francisco, Michelle A, Ray, Debashish, Shrubsole, Sean P, Sobotka, Julia A, Seroussi, Uri, Lao, Robert X, Maity, Tuhin, Wu, Monica Z, McJunkin, Katherine, Morris, Quaid D, Hughes, Timothy R, Wilce, Jacqueline A, Claycomb, Julie M, Weng, Zhiping, Boag, Peter R

“…Proper regulation of germline gene expression is essential for fertility and maintaining species integrity. In the C. elegans germline, a diverse repertoire of…”
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P Granules Protect RNA Interference Genes from Silencing by piRNAs by Ouyang, John Paul T., Folkmann, Andrew, Bernard, Lauren, Lee, Chih-Yung, Seroussi, Uri, Charlesworth, Amanda G., Claycomb, Julie M., Seydoux, Geraldine

“…P granules are perinuclear condensates in C. elegans germ cells proposed to serve as hubs for self/non-self RNA discrimination by Argonautes. We report that a…”
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Analysis of C. elegans Germline Small RNA Pathways by Renaud, Mathias S, Seroussi, Uri, Claycomb, Julie M

“…Sequence-specific gene regulation by small RNA (sRNA) pathways is essential for the development and function of organisms in all domains of life. These…”
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Germ Granules Govern Small RNA Inheritance by Lev, Itamar, Toker, Itai Antoine, Mor, Yael, Nitzan, Anat, Weintraub, Guy, Antonova, Olga, Bhonkar, Ornit, Ben Shushan, Itay, Seroussi, Uri, Claycomb, Julie M., Anava, Sarit, Gingold, Hila, Zaidel-Bar, Ronen, Rechavi, Oded

“…In C. elegans nematodes, components of liquid-like germ granules were shown to be required for transgenerational small RNA inheritance. Surprisingly, we show…”
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