Search Results - "Clay, Selene"

Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy by Khuc, Emily, Bainer, Russell, Wolf, Marie, Clay, Selene M, Weisenberger, Daniel J, Kemmer, Jacquelyn, Weaver, Valerie M, Hwang, David G, Chan, Matilda F

“…Transparency of the human cornea is necessary for vision. Fuchs Endothelial Corneal Dystrophy (FECD) is a bilateral, heritable degeneration of the corneal…”
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MMP12 Inhibits Corneal Neovascularization and Inflammation through Regulation of CCL2 by Wolf, Marie, Clay, Selene M., Zheng, Siyu, Pan, Peipei, Chan, Matilda F.

“…Following corneal injury, coordinated cellular and protein interactions occur at the wound site to restore tissue homeostasis. Regulation of this response is…”
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Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region by Aneas, Ivy, Decker, Donna C., Howard, Chanie L., Sobreira, Débora R., Sakabe, Noboru J., Blaine, Kelly M., Stein, Michelle M., Hrusch, Cara L., Montefiori, Lindsey E., Tena, Juan, Magnaye, Kevin M., Clay, Selene M., Gern, James E., Jackson, Daniel J., Altman, Matthew C., Naureckas, Edward T., Hogarth, Douglas K., White, Steven R., Gomez-Skarmeta, Jose Luis, Schoetler, Nathan, Ober, Carole, Sperling, Anne I., Nóbrega, Marcelo A.

“…Genome-wide association studies (GWAS) have implicated the IL33 locus in asthma, but the underlying mechanisms remain unclear. Here, we identify a 5 kb region…”
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Sex-specific differences in peripheral blood leukocyte transcriptional response to LPS are enriched for HLA region and X chromosome genes by Stein, Michelle M., Conery, Mitch, Magnaye, Kevin M., Clay, Selene M., Billstrand, Christine, Nicolae, Raluca, Naughton, Katherine, Ober, Carole, Thompson, Emma E.

“…Sex-specific differences in prevalence are well documented for many common, complex diseases, especially for immune-mediated diseases, yet the precise…”
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DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma by Magnaye, Kevin M, Clay, Selene M, Nicodemus-Johnson, Jessie, Naughton, Katherine A, Huffman, Janel, Altman, Matthew C, Jackson, Daniel J, Gern, James E, Hogarth, Douglas K, Naureckas, Edward T, White, Steven R, Ober, Carole

“…Maternal asthma (MA) is among the most consistent risk factors for asthma in children. Possible mechanisms for this observation are epigenetic modifications in…”
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Effects of MMP12 on cell motility and inflammation during corneal epithelial repair by Wolf, Marie, Maltseva, Inna, Clay, Selene M., Pan, Peipei, Gajjala, Abhinay, Chan, Matilda F.

“…Corneal epithelial defects are a common cause of ocular morbidity and can result in corneal scarring if they do not heal properly. Matrix metalloproteinases…”
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Characterization of Recruited Mononuclear Phagocytes following Corneal Chemical Injury by Lamy, Ricardo, Wolf, Marie, Bispo, Claudia, Clay, Selene M, Zheng, Siyu, Wolfreys, Finn, Pan, Peipei, Chan, Matilda F

“…Mononuclear phagocytes (MP) have central importance in innate immunity, inflammation, and fibrosis. Recruited MPs, such as macrophages, are plastic cells and…”
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Conserved and Taxon-Specific Patterns of Phenotypic Modularity in the Mammalian Dentition by Takenaka, Risa, Clay, Selene M, Yoo, Sunwoo, Hlusko, Leslea J

“…Synopsis Previous genotype:phenotype mapping of the mouse and primate dentition revealed the presence of pre- and post-canine modules in mice and anthropoid…”
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Overexpression of MMPs in Corneas Requiring Penetrating and Deep Anterior Lamellar Keratoplasty by Wolf, Marie, Clay, Selene M, Oldenburg, Catherine E, Rose-Nussbaumer, Jennifer, Hwang, David G, Chan, Matilda F

“…Matrix metalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases involved in wound healing processes, including neovascularization and…”
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Evidence of strong stabilizing effects on the evolution of boreoeutherian (Mammalia) dental proportions by Monson, Tesla A., Boisserie, Jean‐Renaud, Brasil, Marianne F., Clay, Selene M., Dvoretzky, Rena, Ravindramurthy, Shruti, Schmitt, Christopher A., Souron, Antoine, Takenaka, Risa, Ungar, Peter S., Yoo, Sunwoo, Zhou, Michael, Zuercher, Madeleine E., Hlusko, Leslea J.

“…The dentition is an extremely important organ in mammals with variation in timing and sequence of eruption, crown morphology, and tooth size enabling a range…”
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Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus by Soliai, Marcus M, Kato, Atsushi, Helling, Britney A, Stanhope, Catherine T, Norton, James E, Naughton, Katherine A, Klinger, Aiko I, Thompson, Emma E, Clay, Selene M, Kim, Soyeon, Celedón, Juan C, Gern, James E, Jackson, Daniel J, Altman, Matthew C, Kern, Robert C, Tan, Bruce K, Schleimer, Robert P, Nicolae, Dan L, Pinto, Jayant M, Ober, Carole

“…Genome-wide association studies (GWASs) have identified thousands of variants associated with asthma and other complex diseases. However, the functional…”
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Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings by Dapas, Matthew, Thompson, Emma E, Wentworth-Sheilds, William, Clay, Selene, Visness, Cynthia M, Calatroni, Agustin, Sordillo, Joanne E, Gold, Diane R, Wood, Robert A, Makhija, Melanie, Khurana Hershey, Gurjit K, Sherenian, Michael G, Gruchalla, Rebecca S, Gill, Michelle A, Liu, Andrew H, Kim, Haejin, Kattan, Meyer, Bacharier, Leonard B, Rastogi, Deepa, Altman, Matthew C, Busse, William W, Becker, Patrice M, Nicolae, Dan, O'Connor, George T, Gern, James E, Jackson, Daniel J, Ober, Carole

“…Impaired lung function in early life is associated with the subsequent development of chronic respiratory disease. Most genetic associations with lung function…”
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Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region by Clay, Selene M, Schoettler, Nathan, Goldstein, Andrew M, Carbonetto, Peter, Dapas, Matthew, Altman, Matthew C, Rosasco, Mario G, Gern, James E, Jackson, Daniel J, Im, Hae Kyung, Stephens, Matthew, Nicolae, Dan L, Ober, Carole

“…Genome-wide association studies of asthma have revealed robust associations with variation across the human leukocyte antigen (HLA) complex with independent…”
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Current insights into the genetics of food allergy by Kanchan, Kanika, Clay, Selene, Irizar, Haritz, Bunyavanich, Supinda, Mathias, Rasika A.

“…Food allergy (FA), a growing public health burden in the United States, and familial aggregation studies support strong roles for both genes and environment in…”
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Characterizing Genetic Risks for Asthma by Clay, Selene Marilyn

“…Asthma is a disease of the airways with significant clinical heterogeneity regarding age-of-onset, co-occurrence with allergic diseases, lung function…”
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Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma by Clay, Selene, Alladina, Jehan, Smith, Neal P., Visness, Cynthia M., Wood, Robert A., O’Connor, George T., Cohen, Robyn T., Khurana Hershey, Gurjit K., Kercsmar, Carolyn M., Gruchalla, Rebecca S., Gill, Michelle A., Liu, Andrew H., Kim, Haejin, Kattan, Meyer, Bacharier, Leonard B., Rastogi, Deepa, Rivera-Spoljaric, Katherine, Robison, Rachel G., Gergen, Peter J., Busse, William W., Villani, Alexandra-Chloe, Cho, Josalyn L., Medoff, Benjamin D., Gern, James E., Jackson, Daniel J., Ober, Carole, Dapas, Matthew

“…Most genetic studies of asthma and allergy have focused on common variation in individuals primarily of European ancestry. Studying the role of rare variation…”
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