Search Results - "Clavaguera, Florence"

The propagation of prion-like protein inclusions in neurodegenerative diseases by Goedert, Michel, Clavaguera, Florence, Tolnay, Markus

“…The most common neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, are characterized by the misfolding of a small number of…”
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Brain homogenates from human tauopathies induce tau inclusions in mouse brain by Clavaguera, Florence, Akatsu, Hiroyasu, Fraser, Graham, Crowther, R. Anthony, Frank, Stephan, Hench, Jürgen, Probst, Alphonse, Winkler, David T., Reichwald, Julia, Staufenbiel, Matthias, Ghetti, Bernardino, Goedert, Michel, Tolnay, Markus

“…Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous human neurodegenerative diseases, including Alzheimer’s disease,…”
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The prion-like propagation hypothesis in Alzheimer's and Parkinson's disease by Duyckaerts, Charles, Clavaguera, Florence, Potier, Marie-Claude

“…This study, taking the example of Alzheimer's and Parkinson's diseases, presents the experimental and human data that support the hypothesis that Aβ, tau, and…”
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Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies by Goedert, Michel, Falcon, Ben, Clavaguera, Florence, Tolnay, Markus

“…Neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are characterized by the abnormal aggregation of a small number of…”
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Transmission and spreading of tauopathy in transgenic mouse brain by Crowther, R. Anthony, Clavaguera, Florence, Abramowski, Dorothee, Goedert, Michel, Bolmont, Tristan, Probst, Alphonse, Tolnay, Markus, Fraser, Graham, Staufenbiel, Matthias, Stalder, Anna K, Jucker, Mathias, Beibel, Martin, Frank, Stephan

“…Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease. In the disease…”
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Invited review: Prion-like transmission and spreading of tau pathology by Clavaguera, Florence, Hench, Jürgen, Goedert, Michel, Tolnay, Markus

“…Filaments made of hyperphosphorylated tau protein are encountered in a number of neurodegenerative diseases referred to as ‘tauopathies’. In the most prevalent…”
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"Prion-Like" Templated Misfolding in Tauopathies by Clavaguera, Florence, Lavenir, Isabelle, Falcon, Ben, Frank, Stephan, Goedert, Michel, Tolnay, Markus

“…The soluble microtubule‐associated protein tau forms hyperphosphorylated, insoluble and filamentous inclusions in a number of neurodegenerative diseases…”
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Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice by Ozcelik, Sefika, Fraser, Graham, Castets, Perrine, Schaeffer, Véronique, Skachokova, Zhiva, Breu, Karin, Clavaguera, Florence, Sinnreich, Michael, Kappos, Ludwig, Goedert, Michel, Tolnay, Markus, Winkler, David Theo

“…Altered autophagy contributes to the pathogenesis of Alzheimer's disease and other tauopathies, for which curative treatment options are still lacking. We have…”
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Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice by Clavaguera, Florence, Hench, Jürgen, Lavenir, Isabelle, Schweighauser, Gabriel, Frank, Stephan, Goedert, Michel, Tolnay, Markus

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The Prion-Like Behavior of Assembled Tau in Transgenic Mice by Clavaguera, Florence, Tolnay, Markus, Goedert, Michel

“…Tauopathies constitute neurodegenerative diseases that are characterized by the intracellular deposition of filaments made of hyperphosphorylated tau protein…”
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Clinical and neuropathological diversity of tauopathy in MAPT duplication carriers by Wallon, David, Boluda, Susana, Rovelet-Lecrux, Anne, Thierry, Manon, Lagarde, Julien, Miguel, Laetitia, Lecourtois, Magalie, Bonnevalle, Antoine, Sarazin, Marie, Bottlaender, Michel, Mula, Mathieu, Marty, Serge, Nakamura, Natsuko, Schramm, Catherine, Sellal, François, Jonveaux, Thérèse, Heitz, Camille, Le Ber, Isabelle, Epelbaum, Stéphane, Magnin, Eloi, Zarea, Aline, Rousseau, Stéphane, Quenez, Olivier, Hannequin, Didier, Clavaguera, Florence, Campion, Dominique, Duyckaerts, Charles, Nicolas, Gaël

“…Microduplications of the 17q21.31 chromosomal region encompassing the MAPT gene, which encodes the Tau protein, were identified in patients with a progressive…”
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Argyrophilic grain disease: A late-onset dementia with distinctive features among tauopathies by Tolnay, Markus, Clavaguera, Florence

“…Argyrophilic grain disease (AgD) is a late‐onset dementia morphologically characterized by the presence of abundant spindle‐shaped argyrophilic grains (ArG) in…”
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Tauopathy models and human neuropathology: similarities and differences by Frank, Stephan, Clavaguera, Florence, Tolnay, Markus

“…Much of our current understanding of the pathogenic mechanisms in human neurodegenerative disorders has been derived from animal studies. As such, transgenic…”
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TAU SPREADING IN VIVO by Clavaguera, Florence

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Prion-like properties of Tau assemblies by Clavaguera, Florence, Duyckaerts, Charles, Haïk, Stéphane

“…•Prion diseases are neurodegenerative disorders caused by misfolded PrP protein.•Misfolded Tau protein makes the neurofilamentous lesions found in Alzheimer’s…”
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Intercellular transfer of tau aggregates and spreading of tau pathology: Implications for therapeutic strategies by Clavaguera, Florence, Grueninger, Fiona, Tolnay, Markus

“…Filaments made of hyperphosphorylated tau protein are encountered in a group of neurodegenerative disorders termed tauopathies. The most prevalent tauopathy,…”
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A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity by Ahmed, Zeshan, Cooper, Jane, Murray, Tracey K., Garn, Katya, McNaughton, Emily, Clarke, Hannah, Parhizkar, Samira, Ward, Mark A., Cavallini, Annalisa, Jackson, Samuel, Bose, Suchira, Clavaguera, Florence, Tolnay, Markus, Lavenir, Isabelle, Goedert, Michel, Hutton, Michael L., O’Neill, Michael J.

“…Intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of Alzheimer’s disease, progressive supranuclear palsy, Pick’s disease…”
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Tau transmission by Clavaguera, Florence

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S4‐02‐06: Tau transmission by Clavaguera, Florence

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Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology by Wiersma, Vera I., van Ziel, Anna Maria, Vazquez-Sanchez, Sonia, Nölle, Anna, Berenjeno-Correa, Ernesto, Bonaterra-Pastra, Anna, Clavaguera, Florence, Tolnay, Markus, Musters, René J. P., van Weering, Jan R. T., Verhage, Matthijs, Hoozemans, Jeroen J. M., Scheper, Wiep

“…Granulovacuolar degeneration bodies (GVBs) are membrane-bound vacuolar structures harboring a dense core that accumulate in the brains of patients with…”
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