Search Results - "Clavé, Sergi"

Heterogeneity of Tumor and Immune Cell PD-L1 Expression and Lymphocyte Counts in Surgical NSCLC Samples by Casadevall, David, Clavé, Sergi, Taus, Álvaro, Hardy-Werbin, Max, Rocha, Pedro, Lorenzo, Marta, Menéndez, Silvia, Salido, Marta, Albanell, Joan, Pijuan, Lara, Arriola, Edurne

“…Expression of programmed death-ligand 1 (PD-L1) in tumor cells and infiltrating immune cells was retrospectively analyzed in a cohort of surgically-treated…”
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CD274 (PDL1) and JAK2 genomic amplifications in pulmonary squamous‐cell and adenocarcinoma patients by Clavé, Sergi, Pijuan, Lara, Casadevall, David, Taus, Álvaro, Gimeno, Javier, Hernández‐Llodrà, Silvia, Rodríguez‐Rivera, María, Lorenzo, Marta, Menéndez, Silvia, Albanell, Joan, Espinet, Blanca, Arriola, Edurne, Salido, Marta

“…Aims CD274 (PDL1) and JAK2 (9p24.1) gene amplifications have been recently described in pulmonary carcinomas in association with programmed death‐ligand 1…”
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Concomitant genomic alterations in KRAS mutant advanced lung adenocarcinoma by Gibert, Joan, Clavé, Sergi, Hardy-Werbin, Max, Taus, Álvaro, Rocha, Pedro, Longarón, Raquel, Piquer, Gabriel, Chaib, Imane, Carcereny, Enric, Morán, Teresa, Salido, Marta, Dalmases, Alba, Bellosillo, Beatriz, Arriola, Edurne

“…•KRAS mutant lung adenocarcinoma harbors multiple concurrent genomic alterations.•The most frequent coalterations were TP53 and STK11 point…”
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Comprehensive NGS profiling to enable detection of ALK gene rearrangements and MET amplifications in non-small cell lung cancer by Clavé, Sergi, Jackson, Jennifer B, Salido, Marta, Kames, Jacob, Gerding, Kelly M R, Verner, Ellen L, Kong, Eric F, Weingartner, Elizabeth, Gibert, Joan, Hardy-Werbin, Max, Rocha, Pedro, Riera, Xènia, Torres, Erica, Hernandez, James, Cerqueira, Gustavo, Nichol, Donna, Simmons, John, Taus, Álvaro, Pijuan, Lara, Bellosillo, Beatriz, Arriola, Edurne

“…Next-generation sequencing (NGS) is currently widely used for biomarker studies and molecular profiling to identify concurrent alterations that can lead to the…”
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Dynamics of EGFR Mutation Load in Plasma for Prediction of Treatment Response and Disease Progression in Patients With EGFR-Mutant Lung Adenocarcinoma by Taus, Álvaro, Camacho, Laura, Rocha, Pedro, Hardy-Werbin, Max, Pijuan, Lara, Piquer, Gabriel, López, Eva, Dalmases, Alba, Longarón, Raquel, Clavé, Sergi, Salido, Marta, Albanell, Joan, Bellosillo, Beatriz, Arriola, Edurne

“…Liquid biopsies for the circulating tumor DNA (ctDNA)-based assessment of epidermal growth factor receptor (EGFR) mutations in 221 plasma samples from 33…”
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MET expression and copy number heterogeneity in nonsquamous non-small cell lung cancer (nsNSCLC) by Casadevall, David, Gimeno, Javier, Clavé, Sergi, Taus, Álvaro, Pijuan, Lara, Arumí, Miriam, Lorenzo, Marta, Menéndez, Silvia, Cañadas, Israel, Albanell, Joan, Serrano, Sergio, Espinet, Blanca, Salido, Marta, Arriola, Edurne

“…We aimed to assess MET intratumoral heterogeneity and its potential impact on biomarker-based patient selection as well as potential surrogate biomarkers of…”
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Pre-existing tumor host immunity characterization in resected non-small cell lung cancer by Rocha, Pedro, Rodrigo, Maite, Moliner, Laura, Menendez, Silvia, Masfarré, Laura, Navarro, Nil, Del Rey-Vergara, Raúl, Galindo-Campos, Miguel, Taus, Álvaro, Giner, Mario, Sanchez, Ignacio, Rodríguez-Fuster, Alberto, Aguiló, Rafael, Chalela, Roberto, Sánchez-Font, Albert, Belda, Josep, Curull, Victor, Pijuan, Lara, Casadevall, David, Clavé, Sergi, Bellosillo, Beatriz, Perera-Bel, Júlia, Comerma, Laura, Arriola, Edurne

“…•Lung adenocarcinomas and squamous carcinomas exhibited distinct immunological features within the tumor microenvironment.•CD103+/PD-L1+ tumors present higher…”
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Multicenter Evaluation of the Idylla GeneFusion in Non–Small-Cell Lung Cancer by Depoilly, Thomas, Garinet, Simon, van Kempen, Léon C., Schuuring, Ed, Clavé, Sergi, Bellosillo, Beatriz, Ercolani, Cristiana, Buglioni, Simonetta, Siemanowski, Janna, Merkelbach-Bruse, Sabine, Tischler, Verena, Demes, Melanie-Christin, Paridaens, Henry, Sibille, Catherine, de Montpreville, Vincent Thomas, Rouleau, Etienne, Bartczak, Artur, Pasieka-Lis, Monika, Teo, Ryan Yee Wei, Chuah, Khoon Leong, Barbosa, Marta, Quintana, Carlos, Biscuola, Michele, Delgado-Garcia, Mercedes, Vacirca, Davide, Rappa, Alessandra, Cashmore, Matthew, Smith, Matthew, Jasionowicz, Piotr, Meeney, Adam, Desmeules, Patrice, Terris, Benoit, Mansuet-Lupo, Audrey

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Next-generation Sequencing for ALK and ROS1 Rearrangement Detection in Patients With Non–small-cell Lung Cancer: Implications of FISH-positive Patterns by Clavé, Sergi, Rodon, Natalia, Pijuan, Lara, Díaz, Olga, Lorenzo, Marta, Rocha, Pedro, Taus, Álvaro, Blanco, Remei, Bosch-Barrera, Joaquim, Reguart, Noemí, de la Torre, Noelia, Oliveras, Glòria, Espinet, Blanca, Bellosillo, Beatriz, Puig, Xavier, Arriola, Edurne, Salido, Marta

“…Detection of ALK and ROS1 gene rearrangements in non–small-cell lung cancer is required for directing patient care. Although fluorescence in situ hybridization…”
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Accurate Identification of Predictive Biomarkers of Response to Targeted Therapies in Lung Cancer With Next Generation Sequencing by Moliner, Laura, Fernández, Concepción, Clavé, Sergi, Arriola, Edurne

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Plasmatic KRAS Kinetics for the Prediction of Treatment Response and Progression in Patients With KRAS-mutant Lung Adenocarcinoma by Taus, Álvaro, Camacho, Laura, Rocha, Pedro, Hernández, Ainhoa, Longarón, Raquel, Clavé, Sergi, Fernández-Ibarrondo, Lierni, Salido, Marta, Hardy-Werbin, Max, Fernández-Rodríguez, Concepción, Albanell, Joan, Bellosillo, Beatriz, Arriola, Edurne

“…[Display omitted] KRAS is the most common driver mutation in lung cancer. ctDNA-based assessment offers advantages over tumor as a minimally invasive method…”
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Assessment of ALK status by FISH on 1000 Spanish non-small cell lung cancer patients by Vidal, Joana, Clavé, Sergi, de Muga, Silvia, González, Iria, Pijuan, Lara, Gimeno, Javier, Remón, Jordi, Reguart, Noemí, Viñolas, Nuria, Gironés, Regina, Bernet, Laia, Majem, Margarita, Bosch-Barrera, Joaquim, Porta, Rut, Alonso, Nieves, Palmero, Ramón, Taus, Alvaro, Albanell, Joan, Espinet, Blanca, Salido, Marta, Arriola, Edurne

“…Patients with non-small cell lung cancer (NSCLC) harboring anaplastic lymphoma kinase (ALK) rearrangement selectively respond to ALK inhibitors. Thus,…”
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Complementary value of electron microscopy and immunohistochemistry in the diagnosis of non-small cell lung cancer: A potential role for electron microscopy in the era of targeted therapy by Albero-González, Raquel, Munné-Collado, Jessica, Pijuan, Lara, Simón, Mercedes, Gimeno-Beltrán, Javier, Mojal, Sergi, Salido, Marta, Clavé, Sergi, Juanpere, Nuria, Dalmases, Alba, Comerma, Laura, Vázquez, Ivonne, Sánchez-Font, Albert, Taus, Álvaro, Hernández, Silvia, Lloveras, Belén, Lloreta Trull, Josep

“…With the identification of therapeutic targets for lung adenocarcinoma, it has become mandatory to distinguish it from other entities. Some cases remain…”
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HER-Family Ligands Promote Acquired Resistance to Trastuzumab in Gastric Cancer by Sampera, Aïda, Sánchez-Martín, Francisco Javier, Arpí, Oriol, Visa, Laura, Iglesias, Mar, Menéndez, Sílvia, Gaye, Élisabeth, Dalmases, Alba, Clavé, Sergi, Gelabert-Baldrich, Mariona, Poulsen, Thomas Tuxen, Kragh, Michael, Bellosillo, Beatriz, Albanell, Joan, Rovira, Ana, Montagut, Clara

“…Despite the clinical benefit of trastuzumab, eventually all HER2-amplified gastric cancer tumors develop drug resistance. We aimed to identify molecular…”
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ROS1 copy number alterations are frequent in non-small cell lung cancer by Clavé, Sergi, Gimeno, Javier, Muñoz-Mármol, Ana M, Vidal, Joana, Reguart, Noemí, Carcereny, Enric, Pijuan, Lara, Menéndez, Sílvia, Taus, Álvaro, Mate, José Luís, Serrano, Sergio, Albanell, Joan, Espinet, Blanca, Arriola, Edurne, Salido, Marta

“…We aimed to determine the prevalence and partners of ROS1 rearrangements, to explore the correlation between FISH and IHC assays, and to investigate clinical…”
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RET Fusion Testing in Patients With NSCLC: The RETING Study by Conde, Esther, Hernandez, Susana, Rodriguez Carrillo, Jose Luis, Martinez, Rebeca, Alonso, Marta, Curto, Daniel, Jimenez, Beatriz, Caminoa, Alejandra, Benito, Amparo, Garrido, Pilar, Clave, Sergi, Arriola, Edurne, Esteban-Rodriguez, Isabel, De Castro, Javier, Sansano, Irene, Felip, Enriqueta, Rojo, Federico, Dómine, Manuel, Abdulkader, Ihab, Garcia-Gonzalez, Jorge, Teixido, Cristina, Reguart, Noemi, Compañ, Desamparados, Insa, Amelia, Mancheño, Nuria, Palanca, Sarai, Juan-Vidal, Oscar, Baixeras, Nuria, Nadal, Ernest, Cebollero, Maria, Calles, Antonio, Martin, Paloma, Salas, Clara, Provencio, Mariano, Aranda, Ignacio, Massuti, Bartomeu, Lopez-Vilaro, Laura, Majem, Margarita, Paz-Ares, Luis, Lopez-Rios, Fernando

“…RET inhibitors with impressive overall response rates are now available for patients with NSCLC, yet the identification of RET fusions remains a difficult…”
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Accurate Identification of Predictive Biomarkers of Response to Targeted Therapies in Lung Cancer With Next Generation Sequencing by Moliner, Laura, Fernández, Concepción, Clavé, Sergi, Arriola, Edurne

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Abstract 6443: Enhanced detection of ctDNA molecular response for immunotherapy treated non-small cell lung cancer through analyses of cell-free and matched white blood cell DNA by Jackson, Jennifer B., Rocha, Pedro, White, James R., Georgiadis, Andrew P., Verner, Ellen L., Greer, Amy, Mora, Rafael Bach, Pintó, Laura Masfarré, Navarro, Nil, Taus, Álvaro, Paricio, Beatriz Bellosillo, Clavé, Sergi, Sausen, Mark T., Arriola, Edurne

“…Abstract Introduction: Immune checkpoint inhibitors (ICIs) have greatly improved clinical outcomes for patients with non-small cell lung cancer (NSCLC),…”
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CD 274 ( PDL 1 ) and JAK 2 genomic amplifications in pulmonary squamous‐cell and adenocarcinoma patients by Clavé, Sergi, Pijuan, Lara, Casadevall, David, Taus, Álvaro, Gimeno, Javier, Hernández‐Llodrà, Silvia, Rodríguez‐Rivera, María, Lorenzo, Marta, Menéndez, Silvia, Albanell, Joan, Espinet, Blanca, Arriola, Edurne, Salido, Marta

“…Aims CD 274 ( PDL 1 ) and JAK 2 (9p24.1) gene amplifications have been recently described in pulmonary carcinomas in association with programmed death‐ligand 1…”
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Abstract 6391: Spatial proteomic profiling unveils pre-existing anti-tumor immunity as a hallmark of exceptional benefit from immunotherapy in NSCLC by Hernandez, Sharia, Bach, Rafael, Giner, Mario, Lu, Wei, Kostousov, Larisa, Barnes, Sean, Khan, Khaja, Masfarré, Laura, Villanueva, Xavier, Sanchéz, Ignacio, Navarro, Nil, Taus, Álvaro, Galindo, Miguel, Hardy, Max, Rey-Vergara, Raúl Del, Iñañez, Albert, Sanchez-Espiridion, Beatriz, Moliner, Laura, Clavé, Sergi, Bellosillo, Beatriz, Rovira, Ana, Perera-Bel, Júlia, Wistuba, Ignacio, Arriola, Edurne, Solis, Luisa M., Rocha, Pedro

“…Abstract Background: Immunotherapy is firmly established as a treatment regimen in various solid tumors due to its exceptional benefits observed in a select…”
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