Search Results - "Clausen, Johannes D."

Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity by Bublitz, Maike, Kjellerup, Lasse, Cohrt, Karen O'Hanlon, Gordon, Sandra, Mortensen, Anne Louise, Clausen, Johannes D, Pallin, Thomas David, Hansen, John Bondo, Fuglsang, Anja Thoe, Dalby-Brown, William, Winther, Anne-Marie L

“…We have identified a series of tetrahydrocarbazoles as novel P-type ATPase inhibitors. Using a set of rationally designed analogues, we have analyzed their…”
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SERCA mutant E309Q binds two Ca2+ ions but adopts a catalytically incompetent conformation by Clausen, Johannes D, Bublitz, Maike, Arnou, Bertrand, Montigny, Cédric, Jaxel, Christine, Møller, Jesper Vuust, Nissen, Poul, Andersen, Jens Peter, le Maire, Marc

“…The sarco(endo)plasmic reticulum Ca 2+ ‐ATPase (SERCA) couples ATP hydrolysis to transport of Ca 2+ . This directed energy transfer requires cross‐talk between…”
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Critical Roles of Interdomain Interactions for Modulatory ATP Binding to Sarcoplasmic Reticulum Ca2+-ATPase by Clausen, Johannes D., Holdensen, Anne Nyholm, Andersen, Jens Peter

“…ATP has dual roles in the reaction cycle of sarcoplasmic reticulum Ca2+-ATPase. Upon binding to the Ca2E1 state, ATP phosphorylates the enzyme, and by binding…”
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Distinct Roles of the C-terminal 11th Transmembrane Helix and Luminal Extension in the Partial Reactions Determining the High Ca2+ Affinity of Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 2b (SERCA2b) by Clausen, Johannes D., Vandecaetsbeek, Ilse, Wuytack, Frank, Vangheluwe, Peter, Andersen, Jens Peter

“…The molecular mechanism underlying the characteristic high apparent Ca2+ affinity of SERCA2b relative to SERCA1a and SERCA2a isoforms was studied. The…”
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Purified E255L Mutant SERCA1a and Purified PfATP6 Are Sensitive to SERCA-type Inhibitors but Insensitive to Artemisinins by Cardi, Delphine, Pozza, Alexandre, Arnou, Bertrand, Marchal, Estelle, Clausen, Johannes D., Andersen, Jens Peter, Krishna, Sanjeev, Møller, Jesper V., le Maire, Marc, Jaxel, Christine

“…The antimalarial drugs artemisinins have been described as inhibiting Ca2+-ATPase activity of PfATP6 (Plasmodium falciparum ATP6) after expression in Xenopus…”
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Modulatory ATP Binding Affinity in Intermediate States of E2P Dephosphorylation of Sarcoplasmic Reticulum Ca2+-ATPase by Clausen, Johannes D., McIntosh, David B., Woolley, David G., Andersen, Jens Peter

“…The mechanism of ATP modulation of E2P dephosphorylation of sarcoplasmic reticulum Ca2+-ATPase wild type and mutant forms was examined in nucleotide binding…”
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Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c) by Dally, Saoussen, Bredoux, Raymonde, Corvazier, Elisabeth, Andersen, Jens P, Clausen, Johannes D, Dode, Leonard, Fanchaouy, Mohammed, Gelebart, Pascal, Monceau, Virginie, Del Monte, Frederica, Gwathmey, Judith K, Hajjar, Roger, Chaabane, Chiraz, Bobe, Régis, Raies, Aly, Enouf, Jocelyne

“…We recently documented the expression of a novel human mRNA variant encoding a yet uncharacterized SERCA [SR (sarcoplasmic reticulum)/ER (endoplasmic…”
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Crystal Structure of the Vanadate-Inhibited Ca(2+)-ATPase by Clausen, Johannes D, Bublitz, Maike, Arnou, Bertrand, Olesen, Claus, Andersen, Jens Peter, Møller, Jesper Vuust, Nissen, Poul

“…Vanadate is the hallmark inhibitor of the P-type ATPase family; however, structural details of its inhibitory mechanism have remained unresolved. We have…”
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Crystal Structure of D351A and P312A Mutant Forms of the Mammalian Sarcoplasmic Reticulum Ca2+-ATPase Reveals Key Events in Phosphorylation and Ca2+ Release by Marchand, Alexandre, Winther, Anne-Marie Lund, Holm, Peter Joakim, Olesen, Claus, Montigny, Cedric, Arnou, Bertrand, Champeil, Philippe, Clausen, Johannes D., Vilsen, Bente, Andersen, Jens Peter, Nissen, Poul, Jaxel, Christine, Møller, Jesper Vuust, le Maire, Marc

“…In recent years crystal structures of the sarcoplasmic reticulum Ca2+-ATPase (SERCA1a), stabilized in various conformations with nucleotide and phosphate…”
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Dissection of the Functional Differences between Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA) 1 and 3 Isoforms by Steady-state and Transient Kinetic Analyses by Dode, Leonard, Vilsen, Bente, Van Baelen, Kurt, Wuytack, Frank, Clausen, Johannes D, Andersen, Jens Peter

“…Steady-state and transient-kinetic studies were conducted to characterize the overall and partial reactions of the Ca 2+ -transport cycle mediated by the human…”
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Structural studies of P-type ATPase-ligand complexes using an X-ray free-electron laser by Bublitz, Maike, Nass, Karol, Drachmann, Nikolaj D, Markvardsen, Anders J, Gutmann, Matthias J, Barends, Thomas R M, Mattle, Daniel, Shoeman, Robert L, Doak, R Bruce, Boutet, Sébastien, Messerschmidt, Marc, Seibert, Marvin M, Williams, Garth J, Foucar, Lutz, Reinhard, Linda, Sitsel, Oleg, Gregersen, Jonas L, Clausen, Johannes D, Boesen, Thomas, Gotfryd, Kamil, Wang, Kai-Tuo, Olesen, Claus, Møller, Jesper V, Nissen, Poul, Schlichting, Ilme

“…Membrane proteins are key players in biological systems, mediating signalling events and the specific transport of e.g. ions and metabolites. Consequently,…”
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Identification, Expression, Function, and Localization of a Novel (Sixth) Isoform of the Human Sarco/Endoplasmic Reticulum Ca2+ATPase 3 Gene by Bobe, Régis, Bredoux, Raymonde, Corvazier, Elisabeth, Andersen, Jens Peter, Clausen, Johannes D, Dode, Leonard, Kovács, Tünde, Enouf, Jocelyne

“…Understanding of Ca 2+ signaling requires the knowledge of proteins involved in this process. Among these proteins are sarco/endoplasmic reticulum Ca 2+…”
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Critical Interaction of Actuator Domain Residues Arginine 174, Isoleucine 188, and Lysine 205 with Modulatory Nucleotide in Sarcoplasmic Reticulum Ca2+-ATPase by Clausen, Johannes D., McIntosh, David B., Woolley, David G., Andersen, Jens Peter

“…ATP plays dual roles in the reaction cycle of the sarcoplasmic reticulum Ca2+-ATPase by acting as the phosphorylating substrate as well as in…”
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Crystal Structure of the Vanadate-Inhibited Ca2+-ATPase by Clausen, Johannes D., Bublitz, Maike, Arnou, Bertrand, Olesen, Claus, Andersen, Jens Peter, Møller, Jesper Vuust, Nissen, Poul

“…Vanadate is the hallmark inhibitor of the P-type ATPase family; however, structural details of its inhibitory mechanism have remained unresolved. We have…”
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Localization of a K+-binding Site Involved in Dephosphorylation of the Sarcoplasmic Reticulum Ca2+-ATPase by Sørensen, Thomas Lykke-Møller, Clausen, Johannes D, Jensen, Anne-Marie Lund, Vilsen, Bente, Møller, Jesper Vuust, Andersen, Jens Peter, Nissen, Poul

“…K + plays an important role for the function of the sarco(endo)plasmic reticulum Ca 2+ -ATPase (SERCA), but its binding site within the molecule has remained…”
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ATP-binding Modes and Functionally Important Interdomain Bonds of Sarcoplasmic Reticulum Ca2+-ATPase Revealed by Mutation of Glycine 438, Glutamate 439, and Arginine 678 by Clausen, Johannes D., McIntosh, David B., Anthonisen, Anne Nyholm, Woolley, David G., Vilsen, Bente, Andersen, Jens Peter

“…ATP binds to sarcoplasmic reticulum Ca2+-ATPase both in a phosphorylating (catalytic) mode and in a nonphosphorylating (modulatory) mode, the latter leading to…”
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The SERCA residue Glu340 mediates interdomain communication that guides Ca2+ transport by Geurts, Maxwell M. G., Clausen, Johannes D., Arnou, Bertrand, Montigny, Cédric, Lenoir, Guillaume, Corey, Robin A., Jaxel, Christine, Møller, Jesper V., Nissen, Poul, Andersen, Jens Peter, le Maire, Marc, Bublitz, Maike

“…The sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) is a P-type ATPase that transports Ca2+ from the cytosol into the sarco(endo) plasmic reticulum (SR/ER)…”
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Elucidation of antimicrobial activity and mechanism of action by N-substituted carbazole derivatives by Clausen, Johannes D., Kjellerup, Lasse, Cohrt, Karen O'Hanlon, Hansen, John Bondo, Dalby-Brown, William, Winther, Anne-Marie L.

“…[Display omitted] Compounds belonging to a carbazole series have been identified as potent fungal plasma membrane proton adenosine triphophatase (H+-ATPase)…”
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Novel Zinc-Attenuating Compounds as Potent Broad-Spectrum Antifungal Agents with In Vitro and In Vivo Efficacy by Cohrt, Karen A O'Hanlon, Marín, Laura, Kjellerup, Lasse, Clausen, Johannes D, Dalby-Brown, William, Calera, José Antonio, Winther, Anne-Marie Lund

“…An increase in the incidence of rare but hard-to-treat invasive fungal pathogens as well as resistance to the currently available antifungal drugs calls for…”
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The SERCA residue Glu340 mediates interdomain communication that guides Ca 2+ transport by Geurts, Maxwell M G, Clausen, Johannes D, Arnou, Bertrand, Montigny, Cédric, Lenoir, Guillaume, Corey, Robin A, Jaxel, Christine, Møller, Jesper V, Nissen, Poul, Andersen, Jens Peter, le Maire, Marc, Bublitz, Maike

“…The sarco(endo)plasmic reticulum Ca -ATPase (SERCA) is a P-type ATPase that transports Ca from the cytosol into the sarco(endo)plasmic reticulum (SR/ER) lumen,…”
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