BCG vaccine reactivation after mRNA immunization against COVID-19: case report

The Bacillus Calmette-Guérin (BCG) vaccine is a live attenuated pathogen vaccine used to prevent severe types of tuberculosis. A related immunological event is its scar reactivation. It is usually associated with Kawasaki disease and the use of other immunizers. In this report, we aim to describe th...

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Bibliographic Details
Published in:	Revista médica de Minas Gerais Vol. 33; p. e-33405
Main Authors:	José Paulo Ribeiro Júnior, Maria do Carmo Araújo Palmeira Queiroz, Arnoud de Lucena Flor, Clause Willdys Medeiros Dantas
Format:	Journal Article
Language:	English
Published:	Associação Médica de Minas Gerais 01-10-2023
Subjects:	adverse effects bcg vaccine covid-19
Online Access:	Get full text
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Summary:	The Bacillus Calmette-Guérin (BCG) vaccine is a live attenuated pathogen vaccine used to prevent severe types of tuberculosis. A related immunological event is its scar reactivation. It is usually associated with Kawasaki disease and the use of other immunizers. In this report, we aim to describe the case of a 24-year-old woman with BCG vaccine scar reactivation after administering a Messenger RNA (mRNA) vaccine against COVID-19, BNT162b2. The pathophysiology involved in the scarring reactivation of the BCG vaccine is related to the chaperone proteins. There are still no cases reported in Brazil of BCG scar reactivation after mRNA vaccines. Nevertheless, we conclude that there is no evidence that such a reaction contraindicates a new dose of the vaccine.
ISSN:	0103-880X 2238-3182
DOI:	10.5935/2238-3182.2022e33405-en