Search Results - "Claus Johansen"

IκBζ is a key driver in the development of psoriasis by Johansen, Claus, Mose, Maike, Ommen, Pernille, Bertelsen, Trine, Vinter, Hanne, Hailfinger, Stephan, Lorscheid, Sebastian, Schulze-Osthoff, Klaus, Iversen, Lars

“…Psoriasis is a common immune-mediated, chronic, inflammatory skin disease characterized by hyperproliferation and abnormal differentiation of keratinocytes and…”
Get full text

Transcriptomic Analysis of Hidradenitis Suppurativa: A Unique Molecular Signature with Broad Immune Activation by Ben Abdallah, Hakim, Bregnhøj, Anne, Iversen, Lars, Johansen, Claus

“…Hidradenitis suppurativa is a chronic inflammatory skin disease with limited treatment options. The poorly understood pathogenesis hinders the development of…”
Get full text

Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review by Emmanuel, Thomas, Mistegård, Josephine, Bregnhøj, Anne, Johansen, Claus, Iversen, Lars

“…In health, the non-recirculating nature and long-term persistence of tissue-resident memory T cells (TRMs) in tissues protects against invading pathogens. In…”
Get full text

Heat shock protein 90 inhibition attenuates inflammation in models of atopic dermatitis: a novel mechanism of action by Ben Abdallah, Hakim, Bregnhøj, Anne, Ghatnekar, Gautam, Iversen, Lars, Johansen, Claus

“…Heat shock protein 90 (HSP90) is an important chaperone supporting the function of many proinflammatory client proteins. Recent studies indicate HSP90…”
Get full text

Heat shock protein 90 inhibitor RGRN-305 potently attenuates skin inflammation by Ben Abdallah, Hakim, Seeler, Sabine, Bregnhøj, Anne, Ghatnekar, Gautam, Kristensen, Lasse S, Iversen, Lars, Johansen, Claus

“…Chronic inflammatory skin diseases may have a profound negative impact on the quality of life. Current treatment options may be inadequate, offering an…”
Get full text

Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment by Sabine Seeler, Liviu-Ionut Moldovan, Trine Bertelsen, Henrik Hager, Lars Iversen, Claus Johansen, Jørgen Kjems, Lasse Sommer Kristensen

“…Psoriasis is a common chronic inflammatory skin disease accompanied by heterogenous clinical and histological features, including a characteristic keratinocyte…”
Get full text

Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment by Seeler, Sabine, Moldovan, Liviu-Ionut, Bertelsen, Trine, Hager, Henrik, Iversen, Lars, Johansen, Claus, Kjems, Jørgen, Sommer Kristensen, Lasse

“…Psoriasis is a common chronic inflammatory skin disease accompanied by heterogenous clinical and histological features, including a characteristic keratinocyte…”
Get full text

High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome by Moldovan, Liviu-Ionut, Hansen, Thomas Birkballe, Venø, Morten Trillingsgaard, Okholm, Trine Line Hauge, Andersen, Thomas Levin, Hager, Henrik, Iversen, Lars, Kjems, Jørgen, Johansen, Claus, Kristensen, Lasse Sommer

“…Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation and abnormal differentiation of keratinocytes. It is one of the most…”
Get full text

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling by Ananieva, Olga, Iversen, Lars, Santos, Susana G, Johansen, Claus, Carr, Julia M, Darragh, Joanne, Park, Jin Mo, McIlrath, Joanne, Monk, Claire E, Arthur, J Simon C, Toth, Rachel, Wingate, Andrew

“…Uncontrolled TLR signaling results in excessive inflammation. Arthur and colleagues show that the kinases MSK1 and MSK2 orchestrate a feedback loop involving…”
Get full text

I-Kappa-B-Zeta Regulates Interleukin-17A/Tumor Necrosis Factor-Alpha Mediated Synergistic Induction of Interleukin-19 and Interleukin-20 in Humane Keratinocytes by Bertelsen, Trine, Iversen, Lars, Johansen, Claus

“…Interleukin (IL)-19 and IL-20 are important members of the IL-10 cytokine family, which are known to play a role in inflammatory processes. Both anti-IL-19 and…”
Get full text

Leptin deficiency in mice counteracts imiquimod (IMQ)‐induced psoriasis‐like skin inflammation while leptin stimulation induces inflammation in human keratinocytes by Stjernholm, Theresa, Ommen, Pernille, Langkilde, Ane, Johansen, Claus, Iversen, Lars, Rosada, Cecilia, Stenderup, Karin

“…Leptin is an adipocyte‐derived cytokine secreted mostly by adipose tissue. Serum leptin levels are elevated in obese individuals and correlate positively with…”
Get full text

STAT2 is involved in the pathogenesis of psoriasis by promoting CXCL11 and CCL5 production by keratinocytes by Johansen, Claus, Rittig, Anne Hald, Mose, Maike, Bertelsen, Trine, Weimar, Isabella, Nielsen, Jakob, Andersen, Thomas, Rasmussen, Tue Kruse, Deleuran, Bent, Iversen, Lars

“…The JAK/STAT signaling pathway is suggested to play an important role in the pathogenesis of psoriasis, and recently JAK/STAT inhibitors have shown promising…”
Get full text

Non-random Plaque-site Recurrence of Psoriasis in Patients Treated with Dead Sea Climatotherapy by Emmanuel, Thomas, Lybaek, Dorte, Johansen, Claus, Iversen, Lars

“…Abstract is missing (Short communication)…”
Get full text

RUNX2 as a novel biomarker for early identification of patients progressing to advanced-stage mycosis fungoides by Danielsen, Maria, Emmanuel, Thomas, Nielsen, Morten Muhlig, Lindahl, Lise Maria, Gluud, Maria, Ødum, Niels, Raaby, Line, Steiniche, Torben, Iversen, Lars, Bech, Rikke, Buus, Terkild Brink, Johansen, Claus

“…The majority of patients with mycosis fungoides (MF) have an indolent disease course, but a substantial fraction (20-30%) of patients progress to advanced…”
Get full text

Secukinumab and Dead Sea Climatotherapy Impact Resolved Psoriasis Skin Differently Potentially Affecting Disease Memory by Emmanuel, Thomas, Ignatov, Borislav, Bertelsen, Trine, Litman, Thomas, Nielsen, Morten Muhlig, Brent, Mikkel Bo, Touborg, Toke, Rønsholdt, Anders Benjamin, Petersen, Annita, Boye, Mette, Kaaber, Ida, Sortebech, Daniel, Lybæk, Dorte, Steiniche, Torben, Bregnhøj, Anne, Eidsmo, Liv, Iversen, Lars, Johansen, Claus

“…Secukinumab and Dead Sea treatment result in clear skin for many psoriasis patients, through distinct mechanisms. However, recurrence in the same areas after…”
Get full text

IkBζ is a Key Regulator of Tumour Necrosis Factor-a and Interleukin-17A-mediated Induction of Interleukin-36g in Human Keratinocytes by Ovesen, Sofie Kaas, Schulze-Osthoff, Klaus, Iversen, Lars, Johansen, Claus

“…The interleukin (IL)-36 cytokine family plays an essential role in inflammatory processes in the skin and is implicated in the pathogenesis of psoriasis. This…”
Get full text

Early intervention and disease memory in psoriasis: A literature review by Ben Abdallah, Hakim, Emmanuel, Thomas, Bregnhøj, Anne, Johansen, Claus, Iversen, Lars

“…Psoriasis is a chronic inflammatory skin disease, in which molecular and cellular changes retain following clinical resolution of psoriatic lesions, a form of…”
Get full text

Microsurgical Subinguinal Varicocele Repair of Grade II-III Lesions Associated with Improvements of Testosterone Levels by Elzanaty, Saad, Johansen, Claus

“…Introduction: The results of reports on the association between varicocele repair and testosterone levels were conflicting. The aim of the present study is,…”
Get full text

Effect of Dead Sea Climatotherapy on Psoriasis; A Prospective Cohort Study by Emmanuel, Thomas, Lybæk, Dorte, Johansen, Claus, Iversen, Lars

“…Dead Sea climatotherapy (DSC) is a treatment option for psoriasis in Denmark. However, the response to DSC has not been particularly well studied. We sought to…”
Get full text

Quantification of Immunohistochemically Stained Cells in Skin Biopsies by Emmanuel, Thomas, Brent, Mikkel Bo, Iversen, Lars, Johansen, Claus

“…Immunohistochemical quantification of inflammatory cells in skin biopsies is a valuable tool for diagnosing skin diseases and assessing treatment response. The…”
Get full text