Search Results - "Claus, S"

The caspase‐activated DNase: apoptosis and beyond by Larsen, Brian D., Sørensen, Claus S.

“…Organismal development and function requires multiple and accurate signal transduction pathways to ensure that proper balance between cell proliferation,…”
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WEE1 kinase limits CDK activities to safeguard DNA replication and mitotic entry by Elbæk, Camilla R, Petrosius, Valdemaras, Sørensen, Claus S

“…Precise execution of the cell division cycle is vital for all organisms. The Cyclin dependent kinases (CDKs) are the main cell cycle drivers, however, their…”
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PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response by Simhadri, Srilatha, Vincelli, Gabriele, Huo, Yanying, Misenko, Sarah, Foo, Tzeh Keong, Ahlskog, Johanna, Sørensen, Claus S., Oakley, Gregory G., Ganesan, Shridar, Bunting, Samuel F., Xia, Bing

“…The G2/M checkpoint inhibits mitotic entry upon DNA damage, thereby preventing segregation of broken chromosomes and preserving genome stability. The tumor…”
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Infections of the Spine by Babic, Maja, MD, Simpfendorfer, Claus S., MD

“…Pyogenic infections of the bony spinal column and the intervertebral discs are on a steady rise in an aging western population. Despite advanced medical…”
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ATM/ATR-mediated phosphorylation of PALB2 promotes RAD51 function by Ahlskog, Johanna K, Larsen, Brian D, Achanta, Kavya, Sørensen, Claus S

“…DNA damage activates the ATM and ATR kinases that coordinate checkpoint and DNA repair pathways. An essential step in homology‐directed repair (HDR) of DNA…”
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Self-inflicted DNA breaks in cell differentiation and cancer by Benada, Jan, Alsowaida, Dalal, Megeney, Lynn A., Sørensen, Claus S.

“…Nucleases are employed physiologically to inflict DNA lesions that promote processes such as apoptosis, the evolution of the germline, and adaptation of the…”
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Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes by Shoaib, Muhammad, Chen, Qinming, Shi, Xiangyan, Nair, Nidhi, Prasanna, Chinmayi, Yang, Renliang, Walter, David, Frederiksen, Klaus S., Einarsson, Hjorleifur, Svensson, J. Peter, Liu, Chuan Fa, Ekwall, Karl, Lerdrup, Mads, Nordenskiöld, Lars, Sørensen, Claus S.

“…Histone lysine methylations have primarily been linked to selective recruitment of reader or effector proteins that subsequently modify chromatin regions and…”
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Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing by Shoaib, Muhammad, Walter, David, Gillespie, Peter J., Izard, Fanny, Fahrenkrog, Birthe, Lleres, David, Lerdrup, Mads, Johansen, Jens Vilstrup, Hansen, Klaus, Julien, Eric, Blow, J. Julian, Sørensen, Claus S.

“…The decompaction and re-establishment of chromatin organization immediately after mitosis is essential for genome regulation. Mechanisms underlying chromatin…”
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Dental regulation: Christmas Quality Care inspection by Claus, S.

“…Send your letters to the Editor, British Dental Journal , 64 Wimpole Street, London, W1G 8YS. bdj@bda.org. Priority will be given to letters less than 500…”
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Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability by Zarrizi, Reihaneh, Higgs, Martin R, Voßgröne, Karolin, Rossing, Maria, Bertelsen, Birgitte, Bose, Muthiah, Kousholt, Arne Nedergaard, Rösner, Heike, Network, The Complexo, Ejlertsen, Bent, Stewart, Grant S, Nielsen, Finn Cilius, Sørensen, Claus S

“…Haploinsufficiency of factors governing genome stability underlies hereditary breast and ovarian cancer. One significant pathway that is disabled as a result…”
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Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress by Larsen, Brian D, Benada, Jan, Yung, Philip Yuk Kwong, Bell, Ryan A V, Pappas, George, Urban, Vaclav, Ahlskog, Johanna K, Kuo, Tia T, Janscak, Pavel, Megeney, Lynn A, Elsässer, Simon J, Bartek, Jiri, Sørensen, Claus S

“…Genotoxic therapy such as radiation serves as a frontline cancer treatment, yet acquired resistance that leads to tumor reoccurrence is frequent. We found that…”
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Radiologic Approach to Musculoskeletal Infections by Simpfendorfer, Claus S., MD

“…Imaging is often used to establish a diagnosis of musculoskeletal infections and evaluate the full extent and severity of disease. Imaging should always start…”
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DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation by Kwon, Youngho, Rösner, Heike, Zhao, Weixing, Selemenakis, Platon, He, Zhuoling, Kawale, Ajinkya S., Katz, Jeffrey N., Rogers, Cody M., Neal, Francisco E., Badamchi Shabestari, Aida, Petrosius, Valdemaras, Singh, Akhilesh K., Joel, Marina Z., Lu, Lucy, Holloway, Stephen P., Burma, Sandeep, Mukherjee, Bipasha, Hromas, Robert, Mazin, Alexander, Wiese, Claudia, Sørensen, Claus S., Sung, Patrick

“…The tumor suppressor BRCA2 participates in DNA double-strand break repair by RAD51-dependent homologous recombination and protects stressed DNA replication…”
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Concurrent multiscale analysis without meshing: Microscale representation with CutFEM and micro/macro model blending by Mikaeili, E., Claus, S., Kerfriden, P.

“…In this paper, we develop a novel unfitted multiscale framework that combines two separate scales represented by only one single computational mesh. Our…”
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Fabrication of high tilt angle YBa2Cu3Ox thin films by pulsed laser deposition by Mozhaev, Peter B., Hansen, Jørn Bindslev, Jacobsen, Claus S.

“…YBa 2 Cu 3 O x (YBCO) thin films were deposited on 14°–22° tilted-axes NdGaO 3 (NGO) substrates with pulsed laser deposition. Two orientations of the film are…”
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Effects on Proliferation and Differentiation of Multipotent Bone Marrow Stromal Cells Engineered to Express Growth Factors for Combined Cell and Gene Therapy by Fierro, Fernando A., Kalomoiris, Stefanos, Sondergaard, Claus S., Nolta, Jan A.

“…A key mechanism for mesenchymal stem cells/bone marrow stromal cells (MSCs) to promote tissue repair is by secretion of soluble growth factors (GFs)…”
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Serological assessment of collagen fragments and tumor fibrosis may guide immune checkpoint inhibitor therapy by Jensen, Christina, Nissen, Neel I, Von Arenstorff, Claus S, Karsdal, Morten A, Willumsen, Nicholas

“…Despite the overall clinical success of immune checkpoint inhibitors (ICIs) for treating patients with solid tumors, a large number of patients do not benefit…”
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Update on spinal epidural abscess by Babic, Maja, Simpfendorfer, Claus S, Berbari, Elie F

“…PURPOSE OF REVIEWSpinal epidural abscess (SEA) is still a rare but potentially very morbid infection of the spine. In recent years, the incidence has risen…”
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Complex electrophysiological remodeling in postinfarction ischemic heart failure by Hegyi, Bence, Bossuyt, Julie, Griffiths, Leigh G., Shimkunas, Rafael, Coulibaly, Zana, Jian, Zhong, Grimsrud, Kristin N., Sondergaard, Claus S., Ginsburg, Kenneth S., Chiamvimonvat, Nipavan, Belardinelli, Luiz, Varró, András, Papp, Julius G., Pollesello, Piero, Levijoki, Jouko, Izu, Leighton T., Boyd, W. Douglas, Bányász, Tamás, Bers, Donald M., Chen-Izu, Ye

“…Heart failure (HF) following myocardial infarction (MI) is associated with high incidence of cardiac arrhythmias. Development of therapeutic strategy requires…”
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Mesenchymal Stem Cell Seeding of Porcine Small Intestinal Submucosal Extracellular Matrix for Cardiovascular Applications by Chang, Chia Wei, Petrie, Tye, Clark, Alycia, Lin, Xin, Sondergaard, Claus S, Griffiths, Leigh G

“…In this study, we investigate the translational potential of a novel combined construct using an FDA-approved decellularized porcine small intestinal submucosa…”
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