Search Results - "Claus, Christina"

The emerging landscape of novel 4-1BB (CD137) agonistic drugs for cancer immunotherapy by Claus, Christina, Ferrara-Koller, Claudia, Klein, Christian

“…The clinical development of 4-1BB agonists for cancer immunotherapy has raised substantial interest during the past decade. The first generation of 4-1BB…”
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Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma by Apollonio, Benedetta, Spada, Filomena, Petrov, Nedyalko, Cozzetto, Domenico, Papazoglou, Despoina, Jarvis, Peter, Kannambath, Shichina, Terranova-Barberio, Manuela, Amini, Rose-Marie, Enblad, Gunilla, Graham, Charlotte, Benjamin, Reuben, Phillips, Elisabeth, Ellis, Richard, Nuamah, Rosamond, Saqi, Mansoor, Calado, Dinis P, Rosenquist, Richard, Sutton, Lesley A, Salisbury, Jon, Zacharioudakis, Georgios, Vardi, Anna, Hagner, Patrick R, Gandhi, Anita K, Bacac, Marina, Claus, Christina, Umana, Pablo, Jarrett, Ruth F, Klein, Christian, Deutsch, Alexander, Ramsay, Alan G

“…Recent transcriptomic-based analysis of diffuse large B cell lymphoma (DLBCL) has highlighted the clinical relevance of LN fibroblast and tumor-infiltrating…”
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Combining mathematical modeling, in vitro data and clinical target expression to support bispecific antibody binding affinity selection: a case example with FAP-4-1BBL by Sanchez, Javier, Claus, Christina, McIntyre, Christine, Tanos, Tamara, Boehnke, Axel, Friberg, Lena E, Jönsson, Siv, Frances, Nicolas

“…The majority of bispecific costimulatory antibodies in cancer immunotherapy are capable of exerting tumor-specific T-cell activation by simultaneously engaging…”
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CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies by Al Sayed, Mohamad F., Ruckstuhl, Carla A., Hilmenyuk, Tamara, Claus, Christina, Bourquin, Jean-Pierre, Bornhauser, Beat C., Radpour, Ramin, Riether, Carsten, Ochsenbein, Adrian F.

“…The interaction of the tumor necrosis factor receptor (TNFR) CD27 with its ligand CD70 is an emerging target to treat cancer. CD27 signaling provides…”
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Abstract 6135: Tumor-bearing non-human primates: An unrivaled model for translational cancer immunology research by Ceppi, Maurizio, Hettich, Michael, Teichgräber, Volker, Driessen, Wouter, Tuerck, Dietrich, Marrer-Berger, Estelle, Evers, Stefan, Crameri, Flavio, Gomes, Bruno, Bachl, Jürgen, Klein, Christian, Claus, Christina, Amann, Maria, Krieter, Oliver, Dugan, Greg, Caudell, David, Grayson, Jason, Kiran, Sai Kumar Solingapuram, Cline, Mark

“…Abstract The translatability of mouse models for the clinical development of cancer immunotherapies remains limited because of substantial differences between…”
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A model‐based approach leveraging in vitro data to support dose selection from the outset: A framework for bispecific antibodies in immuno‐oncology by Sánchez, Javier, Claus, Christina, Albrecht, Rosmarie, Gaillard, Brenda C., Marinho, Joana, McIntyre, Christine, Tanos, Tamara, Boehnke, Axel, Friberg, Lena E., Jönsson, Siv, Frances, Nicolas

“…FAP‐4‐1BBL is a bispecific antibody exerting 4‐1BB‐associated T‐cell activation only while simultaneously bound to the fibroblast activation protein (FAP)…”
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Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer by Trüb, Marta, Uhlenbrock, Franziska, Claus, Christina, Herzig, Petra, Thelen, Martin, Karanikas, Vaios, Bacac, Marina, Amann, Maria, Albrecht, Rosemarie, Ferrara-Koller, Claudia, Thommen, Daniela, Rothschield, Sacha, Savic Prince, Spasenija, Mertz, Kirsten D, Cathomas, Gieri, Rosenberg, Robert, Heinzelmann-Schwarz, Viola, Wiese, Mark, Lardinois, Didier, Umana, Pablo, Klein, Christian, Laubli, Heinz, Kashyap, Abhishek S, Zippelius, Alfred

“…BackgroundThe costimulatory receptor 4-1BB (CD137, TNFRSF9) plays an important role in sustaining effective T cell immune responses and is investigated as…”
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P1211: TUMOR‐ACTIVATED LYMPH NODE FIBROBLASTS SUPPRESS T CELL FUNCTION IN DIFFUSE LARGE B CELL LYMPHOMA by Apollonio, Benedetta, Spada, Filomena, Petrov, Nedyalko, Cozzetto, Domenico, Jarvis, Peter, Papazoglou, Despoina, Kannambath, Shichina, Terranova‐Barberio, Manuela, Amini, Rose‐Marie, Enblad, Gunilla, Graham, Charlotte, Benjamin, Reuben, Phillips, Elizabeth H., Ellis, Richard, Nuamah, Rosamond, Saqi, Mansoor, Calado, Dinis, Rosenquist, Richard, Ann Sutton, Lesley, Salisbury, Jon, Zacharioudakis, Georgios, Vardi, Anna, Hagner, Patrick, Gandhi, Anita, Bacac, Marina, Claus, Christina, Umana, Pablo, Jarrett, Ruth, Klein, Christian, Deutsch, Alexander, Ramsay, Alan

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370 Pharmacodynamic assessment of a novel FAP-targeted 4–1BB agonist, administered as single agent and in combination with atezolizumab to patients with advanced solid tumors by Moreno, Victor, Hernandez, Tatiana, Melero, Ignacio, Sanmamed, Miguel, Spanggaard, Iben, Rohrberg, Kristoffer Staal, Tabernero, Josep, Azaro, Analia, Garcia, Maria Martinez, Rodriguez-Vida, Alejo, Claus, Christina, Heil, Florian, Krieter, Oliver, Grimm, Oliver, Canamero, Marta, Duarte, Jose, Nica, Alexandra-Cristina, Davydov, Iakov, Hettich, Michael, Ooi, Chia-Huey, Heichinger, Christian, Guarin, Ernesto, Helbaj, Radoiane, Tanos, Tamara, Nueesch, Eveline, Ceppi, Maurizio, Moreno, Irene, Calvo, Emiliano

“…BackgroundRO7122290 (RO) is a bispecific antibody-like fusion protein that simultaneously targets FAP, abundantly expressed by cancer-associated fibroblasts in…”
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Destruction of lymphoid organ architecture and hepatitis caused by CD4+ T cells by Matter, Matthias S, Hilmenyuk, Tamara, Claus, Christina, Marone, Romina, Schürch, Christian, Tinguely, Marianne, Terracciano, Luigi, Luther, Sanjiv A, Ochsenbein, Adrian F

“…Immune responses have the important function of host defense and protection against pathogens. However, the immune response also causes inflammation and host…”
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CD27 Signaling Increases the Frequency of Regulatory T Cells and Promotes Tumor Growth by CLAUS, Christina, RIETHER, Carsten, SCHÜRCH, Christian, MATTER, Matthias S, HILMENYUK, Tamara, OCHSENBEIN, Adrian F

“…Signaling of the TNF receptor superfamily member CD27 activates costimulatory pathways to elicit T- and B-cell responses. CD27 signaling is regulated by the…”
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Augmenting Efficacy of T-Cell Bispecific Antibodies in AML through a Tumor Stroma-Targeted 4-1BB Agonist by Hänel, Gerulf, Neumann, Anne-Sophie, Pulko, Vesna, Claus, Christina, Leutbecher, Alexandra, Marcinek, Anetta, Zieger, Nora, Buecklein, Veit L, Umana, Pablo, Klein, Christian, Subklewe, Marion

“…Bispecific antibodies represent a promising treatment option for acute myeloid leukemia (AML). We have recently described a novel T-cell bispecific antibody…”
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RG6076 (CD19-4-1BBL): CD19-Targeted 4-1BB Ligand Combination with Glofitamab As an Off-the-Shelf, Enhanced T-Cell Redirection Therapy for B-Cell Malignancies by Herter, Sylvia, Sam, Johannes, Ferrara Koller, Claudia, Diggelmann, Sarah, Bommer, Esther, Schönle, Anne, Claus, Christina, Bacac, Marina, Klein, Christian, Umana, Pablo

“…Synthetic T cell redirecting therapies, using chimeric antigen receptor (CAR)-T cells or CD3-bispecific antibodies targeting B-cell surface antigens such as…”
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CD19-CD28: an affinity-optimized CD28 agonist for combination with glofitamab (CD20-TCB) as off-the-shelf immunotherapy by Sam, Johannes, Hofer, Thomas, Kuettel, Christine, Claus, Christina, Thom, Jenny, Herter, Sylvia, Georges, Guy, Korfi, Koorosh, Lechmann, Martin, Eigenmann, Miro Julian, Marbach, Daniel, Jamois, Candice, Lechner, Katharina, Krishnan, Sreenath M., Gaillard, Brenda, Marinho, Joana, Kronenberg, Sven, Kunz, Leo, Wilson, Sabine, Briner, Stefanie, Gebhardt, Samuel, Varol, Ahmet, Appelt, Birte, Nicolini, Valeria, Speziale, Dario, Bez, Miriam, Bommer, Esther, Eckmann, Jan, Hage, Carina, Limani, Florian, Jenni, Silvia, Schoenle, Anne, Le Clech, Marine, Vallier, Jean-Baptiste Pierre, Colombetti, Sara, Bacac, Marina, Gasser, Stephan, Klein, Christian, Umaña, Pablo

“…•CD19-CD28 provides effective CD28 costimulation to glofitamab-activated T cells without superagonistic properties.•Triple combination with CD19–4-1BBL further…”
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RG6333 (CD19-CD28), a CD19-Targeted Affinity-Optimized CD28 Bispecific Antibody, Enhances and Prolongs the Anti-Tumor Activity of Glofitamab (CD20-TCB) in Preclinical Models by Sam, Johannes, Hofer, Thomas, Kuettel, Christine, Claus, Christina, Herter, Sylvia, Georges, Guy, Thom, Jenny Tosca, Kunz, Leo, Gebhardt, Samuel, Limani, Florian, Briner, Stefanie, Jenni, Silvia, Schönle, Anne, Le Clech, Marine, Varol, Ahmet, Bommer, Esther, Appelt, Birte, Colombetti, Sara, Gasser, Stephan, Bacac, Marina, Klein, Christian, Umana, Pablo

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Abstract LB-389: Combination of TYRP1-TCB, a novel T cell bispecific antibody for the treatment of melanoma, with immunomodulatory agents by Nicolini, Valeria G., Waldhauer, Inja, Freimoser-Grundschober, Anne, Richard, Marine, Fahrni, Linda, Bommer, Esther, Claus, Christina, Sam, Johannes, Colombetti, Sara, Sutmuller, Roger, Levesque, Mitchell P., Irmisch, Anja, Bleul, Conrad, Campbell, Neil, Bacac, Marina, Moessner, Ekkehard, Klein, Christian, Umana, Pablo

“…Abstract In the past decade, many checkpoint inhibitors (CPI) have been approved for melanoma, demonstrating the increasing potential of immunotherapy as a…”
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Abstract 957: Design of CD19-4-1BBL, a novel CD19-targeted 4-1BB ligand for combination therapy with CD20 T-cell bispecific antibodies and CD20 antibodies by Xu, Wei, Sam, Johannes, Perro, Mario, Challier, John, Claus, Christina, Chen, Stanford, Koller, Claudia Ferrara, Mølhøj, Michael, Tournaviti, Stella, Bacac, Marina, Moore, Tom, Klein, Christian, Umana, Pablo

“…Abstract Co-stimulation through 4-1BB has shown promising anti-tumor activity in preclinical models, but the development of 4-1BB agonistic antibodies in the…”
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Abstract 5621: FAP-4-1BBL: A novel versatile tumor-stroma targeted 4-1BB agonist for combination immunotherapy with checkpoint inhibitors, T-cell bispecific antibodies, and ADCC-mediating antibodies by Sam, Johannes, Claus, Christina, Ferrara, Claudia, Lang, Sabine, Nicolini, Valeria, Colombetti, Sara, Teichgräber, Volker, Evers, Stefan, Bacac, Marina, Umana, Pablo, Klein, Christian

“…Abstract For tumor specific co-stimulation via 4-1BB (CD137) a novel tumor-stroma targeted FAP-4-1BB ligand (FAP-4-1BBL) was designed composed of a trimeric…”
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Abstract 1129: Monitoring intratumoral CD8 T cell infiltrates in human stem cell engrafted mice during single agent and combination immunotherapy with T cell bispecific antibodies using the human PET-tracer 89Zr-Df-IAB22M2C by Griessinger, Christoph M., Mascioni, Alessandro, Jia, Fang, Torgov, Michael, Nayak, Tapan, Mohan, Preethi Latha Bhavani, Nicolini, Valeria G., Sam, Johannes, Claus, Christina, Ferrara-Koller, Claudia, Bacac, Marina, Umana, Pablo, Wilson, Ian, Klein, Christian, Tessier, Jean J.

“…Abstract A persisting challenge in cancer immunotherapies (CIT) is the determination of patients responding early during therapy. As major effector cells, CD8…”
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Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8 + T cell immunity by Flatz, Lukas, Pinschewer, Daniel D, Hegazy, Ahmed N, Bergthaler, Andreas, Verschoor, Admar, Claus, Christina, Fernandez, Marylise, Gattinoni, Luca, Johnson, Susan, Kreppel, Florian, Kochanek, Stefan, Broek, Maries van den, Radbruch, Andreas, Lévy, Frédéric, Lambert, Paul-Henri, Siegrist, Claire-Anne, Restifo, Nicholas P, Löhning, Max, Ochsenbein, Adrian F, Nabel, Gary J

“…Lukas Flatz et al . have exploited the characteristics of the lymphocytic choriomeningitis virus (LCMV) to create a vaccine vector platform that elicits potent…”
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