Search Results - "Claudius Thomė"

Collagen II enrichment through scAAV6-RNAi-mediated inhibition of matrix-metalloproteinases 3 and 13 in degenerative nucleus-pulposus cells degenerative disc disease and biological treatment strategies by Mern, Demissew Shenegelegn, Thomé, Claudius

“…Intervertebral disc (IVD) degeneration damaging the extracellular matrix (ECM) of IVDs is the main cause of spine-associated disorders. Degenerative disc…”
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Synergetic enrichment of aggrecan in nucleus pulposus cells by scAAV6-shRNA-mediated knockdown of aggrecanase-1 and aggrecanase-2 by Mern, Demissew Shenegelegn, Thomé, Claudius

“…Degenerative disk disease (DDD) that aggravates structural deterioration of intervertebral disks (IVDs) can be accompanied by painful inflammation and…”
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The influence of the COVID-19 pandemic on traumatic brain injuries in Tyrol: experiences from a state under lockdown by Pinggera, Daniel, Klein, Barbara, Thomé, Claudius, Grassner, Lukas

“…Purpose In February 2020, the federal state of Tyrol in Austria has become one of the epicenters of the COVID-19 pandemic. Tyrol is known for numerous skiing…”
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Impaired fibrinolysis in critically ill COVID-19 patients by Bachler, Mirjam, Bösch, Johannes, Stürzel, Daniel P, Hell, Tobias, Giebl, Andreas, Ströhle, Mathias, Klein, Sebastian J, Schäfer, Volker, Lehner, Georg F, Joannidis, Michael, Thomé, Claudius, Fries, Dietmar

“…Critically ill coronavirus disease 2019 (COVID-19) patients present with a hypercoagulable state with high rates of macrovascular and microvascular thrombosis,…”
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Management of spinal infection: a review of the literature by Lener, Sara, Hartmann, Sebastian, Barbagallo, Giuseppe M. V., Certo, Francesco, Thomé, Claudius, Tschugg, Anja

“…Spinal infection (SI) is defined as an infectious disease affecting the vertebral body, the intervertebral disc, and/or adjacent paraspinal tissue and…”
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Age is associated with unfavorable neuropathological and radiological features and poor outcome in patients with WHO grade 2 and 3 gliomas by Krigers, Aleksandrs, Demetz, Matthias, Thomé, Claudius, Freyschlag, Christian F.

“…With the rising life expectancy and availability of neuroimaging, increased number of older patients will present with diffuse and anaplastic gliomas. The aim…”
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In Reply to the Letter to the Editor Regarding ”Influence of Preoperative Magnetic Resonance Imaging on Surgical Decision Making for Patients with Acute Traumatic Cervical Spinal Cord Injury: A Survey Among Experienced Spine Surgeons by Grassner, Lukas, Thomé, Claudius

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The effect of various options for decompression of degenerated lumbar spine motion segments on the range of motion: a biomechanical in vitro study by Lener, Sara, Schmölz, Werner, Abramovic, Anto, Kluger, Patrick, Thomé, Claudius, Hartmann, Sebastian

“…Background Lumbar spinal stenosis is a common disease in the aging population. Decompression surgery represents the treatment standard, however, a risk of…”
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Pars interarticularis screws for posterior cervical fusion – investigating a new trajectory using a CT-based multiplanar reconstruction: Part I by Lener, Sara, Wipplinger, Christoph, Abramovic, Anto, Koller, Heiko, Thomé, Claudius, Verius, Michael, Hartmann, Sebastian

“…Background Lateral mass screw fixation is the standard for posterior cervical fusion between C3 and C6. Traditional trajectories stabilize but carry risks,…”
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Chiari malformation type I and basilar invagination originating from atlantoaxial instability: a literature review and critical analysis by Wagner, Arthur, Grassner, Lukas, Kögl, Nikolaus, Hartmann, Sebastian, Thomé, Claudius, Wostrack, Maria, Meyer, Bernhard

“…Introduction Recently, a novel hypothesis has been proposed concerning the origin of craniovertebral junction (CVJ) abnormalities. Commonly found in patients…”
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Animal models of regenerative medicine for biological treatment approaches of degenerative disc diseases by Mern, Demissew Shenegelegn, Walsen, Tanja, Beierfuß, Anja, Thomé, Claudius

“…Degenerative disc disease (DDD) is a painful, chronic and progressive disease, which is characterized by inflammation, structural and biological deterioration…”
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A scoring system for the preoperative evaluation of prognosis in spinal infection: the MSI-20 score by Lener, Sara, Wipplinger, Christoph, Lang, Anna, Hartmann, Sebastian, Abramovic, Anto, Thomé, Claudius

“…Spinal infection (SI) is a life-threatening condition and its treatment remains challenging. Recent studies have supported early and aggressive surgery, but…”
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The Clinical Frailty Scale as predictor of overall survival after resection of high-grade glioma by Klingenschmid, Julia, Krigers, Aleksandrs, Pinggera, Daniel, Kerschbaumer, Johannes, Thomé, Claudius, Freyschlag, Christian F.

“…Background The Clinical Frailty Scale (CFS) describes the general level of fitness or frailty and is widely used in geriatric medicine, intensive care and…”
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Intraoperative application of triamcinolone — a risk factor for delayed CSF fistula formation? by Kögl, Nikolaus, Brawanski, Konstantin, Thomé, Claudius, Petr, Ondra

“…Purpose Cerebrospinal fluid (CSF) leaks are a well-known complication in spinal surgery, caused mostly by incidental durotomy (ID). However, delayed…”
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Systemic Inflammatory Response Syndrome as Predictor of Poor Outcome in Nontraumatic Subarachnoid Hemorrhage Patients by Rass, Verena, Gaasch, Max, Kofler, Mario, Schiefecker, Alois Josef, Ianosi, Bogdan-Andrei, Rhomberg, Paul, Beer, Ronny, Pfausler, Bettina, Gizewski, Elke R., Thomé, Claudius, Schmutzhard, Erich, Helbok, Raimund

“…OBJECTIVES:Subarachnoid hemorrhage is a life-threatening disease associated with high mortality and morbidity. A substantial number of patients develop…”
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Effectiveness of posterior decompression techniques compared with conventional laminectomy for lumbar stenosis by Overdevest, Gijsbert M, Jacobs, Wilco, Vleggeert-Lankamp, Carmen, Thomé, Claudius, Gunzburg, Robert, Peul, Wilco

“…The gold standard treatment for symptomatic lumbar stenosis refractory to conservative management is a facet-preserving laminectomy. New techniques of…”
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Surgical decompression in acute spinal cord injury: earlier is better by Maas, Andrew I R, Peul, Wilco, Thomé, Claudius

“…Productive examples in neurology include the IMPACT studies on traumatic brain injury,2 the establishment of Federal Interagency Traumatic Brain Injury…”
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Cerebral Autoregulation in the Prediction of Delayed Cerebral Ischemia and Clinical Outcome in Poor-Grade Aneurysmal Subarachnoid Hemorrhage Patients by Gaasch, Max, Schiefecker, Alois J., Kofler, Mario, Beer, Ronny, Rass, Verena, Pfausler, Bettina, Thomé, Claudius, Schmutzhard, Erich, Helbok, Raimund

“…OBJECTIVES:Pressure reactivity index and oxygen reactivity index are used to assess cerebral autoregulation after acute brain injury. The value of…”
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Effect of the COVID-19 Pandemic on Patient Presentation and Perception to a Neurosurgical Outpatient Clinic by Pinggera, Daniel, Kerschbaumer, Johannes, Grassner, Lukas, Demetz, Matthias, Hartmann, Sebastian, Thomé, Claudius

“…The world currently faces the novel COVID-19 pandemic, with cutbacks in patient care. Little is known about the effects of a pandemic on the presentation and…”
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Mind the gap—the use of sodium fluoresceine for resection of brain metastases to improve the resection rate by Kerschbaumer, Johannes, Demetz, Matthias, Krigers, Aleksandrs, Pinggera, Daniel, Spinello, Antonio, Thomé, Claudius, Freyschlag, Christian F.

“…Introduction and purpose Brain metastases appear to be well resectable due to dissectable tumor margins, but postoperative MRI quite often depicts residual…”
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