Search Results - "Claudio Cuello"

Early and Late CNS Inflammation in Alzheimer’s Disease: Two Extremes of a Continuum? by Cuello, A. Claudio

“…In 1990 it was reported that individuals receiving NSAIDs (non-steroidal anti-inflammatory drugs) showed a markedly reduced prevalence of Alzheimer’s disease…”
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NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo by Qi, Yingjie, Klyubin, Igor, Cuello, A. Claudio, Rowan, Michael J.

“…Pro-inflammatory mechanisms have recently emerged as an important component of early Alzheimer's disease (AD) pathogenesis. A particularly attractive…”
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Reimagining cholinergic therapy for Alzheimer's disease by Giacobini, Ezio, Cuello, A Claudio, Fisher, Abraham

“…Presently, enhancement of cholinergic neurotransmission via cholinesterase inhibitors represents the main available approach to treat cognitive and behavioral…”
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The Brain NGF Metabolic Pathway in Health and in Alzheimer's Pathology by Cuello, A Claudio, Pentz, Rowan, Hall, Hélène

“…Emerging research has re-emphasized the role of the cortical cholinergic system in the symptomology and progression of Alzheimer's disease (AD). Basal…”
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The cholinergic system in the pathophysiology and treatment of Alzheimer's disease by Hampel, Harald, Mesulam, M.-Marsel, Cuello, A Claudio, Farlow, Martin R, Giacobini, Ezio, Grossberg, George T, Khachaturian, Ara S, Vergallo, Andrea, Cavedo, Enrica, Snyder, Peter J, Khachaturian, Zaven S

“…Hampel et al. review the role of the cholinergic system in cognition and how cholinergic deficits in Alzheimer's disease interact with other aspects of disease…”
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The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers disease by Pentz, Rowan, Iulita, M. Florencia, Ducatenzeiler, Adriana, Bennett, David A., Cuello, A. Claudio

“…The NGF metabolic pathway entails the proteins that mature pro-nerve growth factor (proNGF) to NGF and those that degrade NGF. Basal forebrain cholinergic…”
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Connecting the “Dots”: From Free Radical Lipid Autoxidation to Cell Pathology and Disease by Foret, Morgan K, Lincoln, Richard, Do Carmo, Sonia, Cuello, A. Claudio, Cosa, Gonzalo

“…Our understanding of lipid peroxidation in biology and medicine is rapidly evolving, as it is increasingly implicated in various diseases but also recognized…”
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Nerve growth factor metabolic dysfunction in Alzheimer's disease and Down syndrome by Iulita, M. Florencia, Cuello, A. Claudio

“…Highlights • Alzheimer's disease (AD) and Down syndrome (DS) share degeneration of nerve growth factor (NGF)-dependent basal forebrain cholinergic neurons. •…”
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Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain by Welikovitch, Lindsay A., Do Carmo, Sonia, Maglóczky, Zsófia, Malcolm, Janice C., Lőke, János, Klein, William L., Freund, Tamás, Cuello, A. Claudio

“…Chronic inflammation during Alzheimer’s disease (AD) is most often attributed to sustained microglial activation in response to amyloid-β (Aβ) plaque deposits…”
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Aβ-induced vulnerability propagates via the brain’s default mode network by Pascoal, Tharick A., Mathotaarachchi, Sulantha, Kang, Min Su, Mohaddes, Sara, Shin, Monica, Park, Ah Yeon, Parent, Maxime J., Benedet, Andrea L., Chamoun, Mira, Therriault, Joseph, Hwang, Heungsun, Cuello, A. Claudio, Misic, Bratislav, Soucy, Jean-Paul, Aston, John A. D., Gauthier, Serge, Rosa-Neto, Pedro

“…The link between brain amyloid-β (Aβ), metabolism, and dementia symptoms remains a pressing question in Alzheimer’s disease. Here, using positron emission…”
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The NGF Metabolic Pathway in the CNS and its Dysregulation in Down Syndrome and Alzheimer's Disease by Iulita, M Florencia, Cuello, A Claudio

“…It is well established that individuals with Down syndrome develop Alzheimer's disease neuropathology by middle age. Both in Alzheimer's disease and Down…”
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A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease by Hampel, Harald, Caraci, Filippo, Cuello, A Claudio, Caruso, Giuseppe, Nisticò, Robert, Corbo, Massimo, Baldacci, Filippo, Toschi, Nicola, Garaci, Francesco, Chiesa, Patrizia A, Verdooner, Steven R, Akman-Anderson, Leyla, Hernández, Félix, Ávila, Jesús, Emanuele, Enzo, Valenzuela, Pedro L, Lucía, Alejandro, Watling, Mark, Imbimbo, Bruno P, Vergallo, Andrea, Lista, Simone

“…Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and represents one of the earliest pathomechanistic alterations throughout…”
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eIF2α controls memory consolidation via excitatory and somatostatin neurons by Sharma, Vijendra, Sood, Rapita, Khlaifia, Abdessattar, Eslamizade, Mohammad Javad, Hung, Tzu-Yu, Lou, Danning, Asgarihafshejani, Azam, Lalzar, Maya, Kiniry, Stephen J., Stokes, Matthew P., Cohen, Noah, Nelson, Alissa J., Abell, Kathryn, Possemato, Anthony P., Gal-Ben-Ari, Shunit, Truong, Vinh T., Wang, Peng, Yiannakas, Adonis, Saffarzadeh, Fatemeh, Cuello, A. Claudio, Nader, Karim, Kaufman, Randal J., Costa-Mattioli, Mauro, Baranov, Pavel V., Quintana, Albert, Sanz, Elisenda, Khoutorsky, Arkady, Lacaille, Jean-Claude, Rosenblum, Kobi, Sonenberg, Nahum

“…An important tenet of learning and memory is the notion of a molecular switch that promotes the formation of long-term memory 1 – 4 . The regulation of…”
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Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s disease by Kang, Min Su, Aliaga, Arturo Aliaga, Shin, Monica, Mathotaarachchi, Sulantha, Benedet, Andrea L., Pascoal, Tharick A., Therriault, Joseph, Chamoun, Mira, Savard, Melissa, Devenyi, Gabriel A., Mathieu, Axel, Chakravarty, M. Mallar, Sandelius, Åsa, Blennow, Kaj, Zetterberg, Henrik, Soucy, Jean-Paul, Cuello, A. Claudio, Massarweh, Gassan, Gauthier, Serge, Rosa-Neto, Pedro

“…Neurofilament light chain (NFL) measurement has been gaining strong support as a clinically useful neuronal injury biomarker for various neurodegenerative…”
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mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation by Wong, Calvin, Barkai, Omer, Wang, Feng, Thörn Pérez, Carolina, Lev, Shaya, Cai, Weihua, Tansley, Shannon, Yousefpour, Noosha, Hooshmandi, Mehdi, Lister, Kevin C, Latif, Mariam, Cuello, A Claudio, Prager-Khoutorsky, Masha, Mogil, Jeffrey S, Séguéla, Philippe, De Koninck, Yves, Ribeiro-da-Silva, Alfredo, Binshtok, Alexander M, Khoutorsky, Arkady

“…The encoding of noxious stimuli into action potential firing is largely mediated by nociceptive free nerve endings. Tissue inflammation, by changing the…”
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Editorial: The Involvement of NGF in the Alzheimer's Pathology by Cuello, A. Claudio

“…Trophic factors were found responsible for synaptic patterning, developmental survival of specific neuronal systems and neuronal-synaptic phenotypic…”
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Primacy of vision shapes behavioral strategies and neural substrates of spatial navigation in marmoset hippocampus by Piza, Diego B., Corrigan, Benjamin W., Gulli, Roberto A., Do Carmo, Sonia, Cuello, A. Claudio, Muller, Lyle, Martinez-Trujillo, Julio

“…The role of the hippocampus in spatial navigation has been primarily studied in nocturnal mammals, such as rats, that lack many adaptations for daylight…”
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A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: Proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer's pathology by Pentz, Rowan, Iulita, M. Florencia, Mikutra-Cencora, Maya, Ducatenzeiler, Adriana, Bennett, David A., Cuello, A. Claudio

“…Matrix metalloproteinase-3 (MMP-3) has been associated with risk of Alzheimer's disease (AD). In this study we introduce a novel role for MMP-3 in degrading…”
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Activity-Dependent Release of Precursor Nerve Growth Factor, Conversion to Mature Nerve Growth Factor, and Its Degradation by a Protease Cascade by Bruno, Martin A., Cuello, A. Claudio

“…In this report, we provide direct demonstration that the neurotrophin nerve growth factor (NGF) is released in the extracellular space in an activity-dependent…”
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Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype by Allard, Simon, Leon, Wanda C, Pakavathkumar, Prateep, Bruno, Martin A, Ribeiro-da-Silva, Alfredo, Cuello, A Claudio

“…Cortical cholinergic atrophy plays a significant role in the cognitive loss seen with aging and in Alzheimer's disease (AD), but the mechanisms leading to it…”
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