Search Results - "Claudia, Roskopf C"

Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells by Braciak, Todd A., Roskopf, Claudia C., Wildenhain, Sarah, Fenn, Nadja C., Schiller, Christian B., Schubert, Ingo A., Jacob, Uwe, Honegger, Annemarie, Krupka, Christina, Subklewe, Marion, Spiekermann, Karsten, Hopfner, Karl-Peter, Fey, Georg H., Aigner, Michael, Krause, Stefan, Mackensen, Andreas, Oduncu, Fuat S.

“…A number of agents designed for immunotherapy of Acute Myeloid Leukemia (AML) are in preclinical and early clinical development. Most of them target a single…”
Get full text

Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells by Roskopf, Claudia C, Braciak, Todd A, Fenn, Nadja C, Kobold, Sebastian, Fey, Georg H, Hopfner, Karl-Peter, Oduncu, Fuat S

“…Simultaneous targeting of multiple tumor-associated antigens (TAAs) in cancer immunotherapy is presumed to enhance tumor cell selectivity and to reduce immune…”
Get full text

Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody by Chatzopoulou, Elisavet I, Roskopf, Claudia C, Sekhavati, Farzad, Braciak, Todd A, Fenn, Nadja C, Hopfner, Karl-Peter, Oduncu, Fuat S, Fey, Georg H, Rädler, Joachim O

“…Cancer therapy via redirected lysis mediated by antibodies and antibody-derived agents relies on the availability of substantial numbers of sufficiently active…”
Get more information

ITOC2 – 024. Selective lysis of biphenotypic leukaemia cells is mediated by dual-targeting triplebody 33-3-19 treatment by Claudia, Roskopf C, Todd, Braciak A, Nadja, Fenn, Sebastian, Kobold, Uwe, Jacob, Georg, Fey H, Karl-Peter, Hopfner, Fuat, Oduncu S

“…We recently reported that triplebody 19-3-19 can engage and activate T cells as cytolytic effectors via a central OKT3-derived single chain variable fragment…”
Get full text

NK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2 by Braciak, Todd A, Wildenhain, Sarah, Roskopf, Claudia C, Schubert, Ingo A, Fey, Georg H, Jacob, Uwe, Hopfner, Karl-Peter, Oduncu, Fuat S

“…The capacity of patient's Natural Killer cells (NKs) to be activated for cytolysis is an important prerequisite for the success of antibody-derived agents such…”
Get full text

CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells by Schiller, Christian B, Braciak, Todd A, Fenn, Nadja C, Seidel, Ursula J E, Roskopf, Claudia C, Wildenhain, Sarah, Honegger, Annemarie, Schubert, Ingo A, Schele, Alexandra, Lämmermann, Kerstin, Fey, Georg H, Jacob, Uwe, Lang, Peter, Hopfner, Karl-Peter, Oduncu, Fuat S

“…Triplebodies are antibody-derived recombinant proteins carrying 3 antigen-binding domains in a single polypeptide chain. Triplebody SPM-1 was designed for…”
Get full text

T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell by Roskopf, Claudia C, Schiller, Christian B, Braciak, Todd A, Kobold, Sebastian, Schubert, Ingo A, Fey, Georg H, Hopfner, Karl-Peter, Oduncu, Fuat S

“…Triplebody 19-3-19, an antibody-derived protein, carries three single chain fragment variable domains in tandem in a single polypeptide chain. 19-3-19 binds…”
Get full text