Search Results - "Claude, L."
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Kinetic Resolution of β‑Branched Aldehydes through Peptide-Catalyzed Conjugate Addition Reactions
Published in Journal of the American Chemical Society (17-07-2024)“…The catalytic kinetic resolution of racemic β-branched aldehydes offers a straightforward stereoselective entry to aldehydes and addition products. Yet,…”
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Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species
Published in PLoS pathogens (02-05-2018)“…Cholinergic agonists such as levamisole and pyrantel are widely used as anthelmintics to treat parasitic nematode infestations. These drugs elicit spastic…”
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Prevalence of School Bullying Among Youth with Autism Spectrum Disorders: A Systematic Review and Meta-Analysis
Published in Autism research (01-06-2016)“…The true extent of school bullying among youth with autism spectrum disorders (ASD) remains an underexplored area. The purpose of this meta‐analysis is to: (a)…”
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Pharmacological characterization of novel heteromeric GluCl subtypes from Caenorhabditis elegans and parasitic nematodes
Published in British journal of pharmacology (01-03-2022)“…Background and Purpose Macrocyclic lactones are the most widely used broad‐spectrum anthelmintic drugs for the treatment of parasitic nematodes affecting both…”
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Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions
Published in International journal for parasitology (01-12-2014)“…•We report on the Consortium for Anthelmintic Resistance and Susceptibility 2013 meeting.•Recent advances in the identification of markers for anthelmintic…”
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Diversity, trait preferences, management and utilization of yams landraces (Dioscorea species): an orphan crop in DR Congo
Published in Scientific reports (10-02-2022)“…Yam ( Dioscorea spp.) is cultivated in many villages of DR Congo as a means to sustain food security and alleviate poverty. However, the extent of the existing…”
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The molecular targets of ivermectin and lotilaner in the human louse Pediculus humanus humanus: New prospects for the treatment of pediculosis
Published in PLoS pathogens (01-02-2021)“…Control of infestation by cosmopolitan lice (Pediculus humanus) is increasingly difficult due to the transmission of parasites resistant to pediculicides…”
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Modelling organophosphate intoxication in C. elegans highlights nicotinic acetylcholine receptor determinants that mitigate poisoning
Published in PloS one (21-04-2023)“…Organophosphate intoxication via acetylcholinesterase inhibition executes neurotoxicity via hyper stimulation of acetylcholine receptors. Here, we use the…”
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A mathematical finance approach to the stochastic and intermittent viscosity fluctuations in living cells
Published in Soft matter (07-07-2020)“…Here we report on the viscosity of eukaryotic living cells, as a function of time, and on the application of stochastic models to analyze its temporal…”
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Transcriptome of the synganglion in the tick Ixodes ricinus and evolution of the cys-loop ligand-gated ion channel family in ticks
Published in BMC genomics (23-06-2022)“…Abstract Background Ticks represent a major health issue for humans and domesticated animals. Exploring the expression landscape of the tick’s central nervous…”
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Pre-birth acquisition of personhood: Incremental accrual of attributes as the framework for individualization by serial and concurrently acting developmental factors
Published in Frontiers in reproductive health (20-03-2023)“…Discrete events and processes influence development of individual humans. Attribution of personhood to any individual human being cannot be disconnected from…”
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The presence and relative frequency detection of the levamisole-resistance-associated S168T substitution in hco-acr-8 in Haemonchus contortus
Published in International journal for parasitology -- drugs and drug resistance (01-04-2023)“…Parasitic sheep nematodes, among which Haemonchus contortus is often considered to be the most clinically important, exact a significant toll on the animals,…”
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The Caenorhabditis elegans DEG-3/DES-2 Channel Is a Betaine-Gated Receptor Insensitive to Monepantel
Published in Molecules (Basel, Switzerland) (05-01-2022)“…Natural plant compounds, such as betaine, are described to have nematocidal properties. Betaine also acts as a neurotransmitter in the free-living model…”
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Sexual Knowledge, Desires, and Experience of Adolescents and Young Adults With an Autism Spectrum Disorder: An Exploratory Study
Published in Frontiers in psychiatry (09-06-2021)“…Although most persons with an Autism Spectrum Disorder (ASD) wish to have romantic and/or sexual relationships, little is known about self-report sexuality of…”
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Controlling the spin of co atoms on pt(111) by hydrogen adsorption
Published in Physical review letters (13-03-2015)“…We investigate the effect of H adsorption on the magnetic properties of individual Co atoms on Pt(111) with scanning tunneling microscopy. For pristine Co…”
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The narrow-spectrum anthelmintic oxantel is a potent agonist of a novel acetylcholine receptor subtype in whipworms
Published in PLoS pathogens (01-02-2021)“…In the absence of efficient alternative strategies, the control of parasitic nematodes, impacting human and animal health, mainly relies on the use of…”
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Functional validation of novel levamisole resistance marker S168T in Haemonchus contortus
Published in International journal for parasitology -- drugs and drug resistance (01-04-2024)“…Recently, a S168T variant in the acetylcholine receptor subunit ACR-8 was associated with levamisole resistance in the parasitic helminth Haemonchus contortus…”
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Investigation of acetylcholine receptor diversity in a nematode parasite leads to characterization of tribendimidine- and derquantel-sensitive nAChRs
Published in PLoS pathogens (01-01-2014)“…Nicotinic acetylcholine receptors (nAChRs) of parasitic nematodes are required for body movement and are targets of important "classical" anthelmintics like…”
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Functional Characterization of a Novel Class of Morantel-Sensitive Acetylcholine Receptors in Nematodes
Published in PLoS pathogens (01-12-2015)“…Acetylcholine receptors are pentameric ligand-gated channels involved in excitatory neuro-transmission in both vertebrates and invertebrates. In nematodes,…”
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Action of Carvacrol on Parascaris sp. and Antagonistic Effect on Nicotinic Acetylcholine Receptors
Published in Pharmaceuticals (Basel, Switzerland) (26-05-2021)“…Parascaris sp. is the only ascarid parasitic nematode in equids and one of the most threatening infectious organisms in horses. Only a limited number of…”
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