Search Results - "Clatworthy, Anne E"

Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world by Levraud, Jean-Pierre, Rawls, John F, Clatworthy, Anne E

“…Animals rely heavily on their nervous and immune systems to perceive and survive within their environment. Despite the traditional view of the brain as an…”
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A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase by Wellington, Samantha, Nag, Partha P, Michalska, Karolina, Johnston, Stephen E, Jedrzejczak, Robert P, Kaushik, Virendar K, Clatworthy, Anne E, Siddiqi, Noman, McCarren, Patrick, Bajrami, Besnik, Maltseva, Natalia I, Combs, Senya, Fisher, Stewart L, Joachimiak, Andrzej, Schreiber, Stuart L, Hung, Deborah T

“…High-throughput screening identifies an inhibitor of the interaction between α- and β-subunits of the Mycobacterium tuberculosis (Mtb) tryptophan synthase,…”
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Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32 by Stanley, Sarah A., Kawate, Tomohiko, Iwase, Noriaki, Shimizu, Motohisa, Clatworthy, Anne E., Kazyanskaya, Edward, Sacchettini, James C., Ioerger, Thomas R., Siddiqi, Noman A., Minami, Shoko, Aquadro, John A., Grant, Sarah Schmidt, Rubin, Eric J., Hung, Deborah T.

“…Infection with the bacterial pathogen Mycobacterium tuberculosis imposes an enormous burden on global public health. New antibiotics are urgently needed to…”
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Genetic factors affecting storage and utilization of lipids during dormancy in Mycobacterium tuberculosis by Sturm, Alexander, Sun, Penny, Avila-Pacheco, Julian, Clatworthy, Anne E, Bloom-Ackermann, Zohar, Wuo, Michael G, Gomez, James E, Jin, Soomin, Clish, Clary B, Kiessling, Laura L, Hung, Deborah T

“…(Mtb) can adopt a non-growing dormant state during infection that may be critical to both active and latent tuberculosis. During dormancy, Mtb is widely…”
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Pseudomonas aeruginosa Infection of Zebrafish Involves both Host and Pathogen Determinants by Clatworthy, Anne E, Lee, Jenny See-Wai, Leibman, Mark, Kostun, Zachary, Davidson, Alan J, Hung, Deborah T

“…Zebrafish (Danio rerio) have a number of strengths as a host model for infection, including genetic tractability, a vertebrate immune system similar to that of…”
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The Two-Component Sensor KinB Acts as a Phosphatase To Regulate Pseudomonas aeruginosa Virulence by CHAND, Nikhilesh S, CLATWORTHY, Anne E, HUNG, Deborah T

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Sensor Kinase KinB Regulates Virulence in Acute Pseudomonas aeruginosa Infection by CHAND, Nikhilesh S, SEE-WAI LEE, Jenny, CLATWORTHY, Anne E, GOLAS, Aaron J, SMITH, Roger S, HUNG, DeborahT

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Targeting virulence: a new paradigm for antimicrobial therapy by Hung, Deborah T, Clatworthy, Anne E, Pierson, Emily

“…Clinically significant antibiotic resistance has evolved against virtually every antibiotic deployed. Yet the development of new classes of antibiotics has…”
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CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells by Slater, Louise H., Hett, Erik C., Clatworthy, Anne E., Mark, Kevin G., Hung, Deborah T.

“…Bacterial toxins have evolved successful strategies for coopting host proteins to access the cytosol of host cells. Anthrax lethal factor (LF) enters the…”
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Defining the core essential genome of Pseudomonas aeruginosa by Poulsen, Bradley E., Yang, Rui, Clatworthy, Anne E., White, Tiantian, Osmulski, Sarah J., Li, Li, Penaranda, Cristina, Lander, Eric S., Shoresh, Noam, Hung, Deborah T.

“…Genomics offered the promise of transforming antibiotic discovery by revealing many new essential genes as good targets, but the results fell short of the…”
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A dual-plasmid CRISPR/Cas9-based method for rapid and efficient genetic disruption in Mycobacterium abscessus by Neo, Donavan Marcus, Clatworthy, Anne E, Hung, Deborah T

“…is increasingly recognized for causing infections that are notoriously difficult to treat, owing to its large arsenal of intrinsic antibiotic resistance…”
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Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae by Ernst, Christoph M., Braxton, Julian R., Rodriguez-Osorio, Carlos A., Zagieboylo, Anna P., Li, Li, Pironti, Alejandro, Manson, Abigail L., Nair, Anil V., Benson, Maura, Cummins, Kaelyn, Clatworthy, Anne E., Earl, Ashlee M., Cosimi, Lisa A., Hung, Deborah T.

“…Among the most urgent public health threats is the worldwide emergence of carbapenem-resistant Enterobacteriaceae 1 – 4 , which are resistant to the antibiotic…”
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Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation by Warrier, Thulasi, Romano, Keith P, Clatworthy, Anne E, Hung, Deborah T

“…The golden age of antibiotic discovery in the 1940s-1960s saw the development and deployment of many different classes of antibiotics, revolutionizing the…”
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The Use of Tn-Seq and the FiTnEss Analysis to Define the Core Essential Genome of Pseudomonas aeruginosa by Poulsen, Bradley E, Clatworthy, Anne E, Hung, Deborah T

“…Transposon-insertion sequencing (Tn-Seq) allows for identification of bacterial genes and pathways essential for growth under a given condition. A transposon…”
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Whole-organism phenotypic screening for anti-infectives promoting host health by Clatworthy, Anne E., Romano, Keith P., Hung, Deborah T.

“…To date, antibiotics have been identified on the basis of their ability to kill bacteria or inhibit their growth rather than directly for their capacity to…”
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3-Hydroxykynurenine targets kainate receptors to promote defense against infection by Parada-Kusz, Margarita, Clatworthy, Anne E, Goering, Emily R, Blackwood, Stephanie M, Shigeta, Jack Y, Mashin, Eivgeni, Salm, Elizabeth J, Choi, Catherine, Combs, Senya, Lee, Jenny S W, Rodriguez-Osorio, Carlos, Clish, Clary, Tomita, Susumu, Hung, Deborah T

“…Bacterial infection involves a complex interaction between the pathogen and host where the outcome of infection is not solely determined by pathogen…”
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Author Correction: Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae by Ernst, Christoph M., Braxton, Julian R., Rodriguez-Osorio, Carlos A., Zagieboylo, Anna P., Li, Li, Pironti, Alejandro, Manson, Abigail L., Nair, Anil V., Benson, Maura, Cummins, Kaelyn, Clatworthy, Anne E., Earl, Ashlee M., Cosimi, Lisa A., Hung, Deborah T.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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The MRE11-RAD50-XRS2 Complex, in Addition to Other Non-homologous End-joining Factors, Is Required for V(D)J Joining in Yeast by Clatworthy, Anne E., Valencia-Burton, Maria A., Haber, James E., Oettinger, Marjorie A.

“…Lymphoid cells of the vertebrate immune system rely on factors in the non-homologous end-joining (NHEJ) DNA repair pathway to form signal joints during V(D)J…”
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Bacterial toxins and small molecules elucidate endosomal trafficking by Slater, Louise H, Clatworthy, Anne E, Hung, Deborah T

“…Bacterial toxins and small molecules are useful tools for studying eukaryotic cell biology. In a recent issue of PNAS , Gillespie and colleagues describe a…”
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V(D)J Recombination and RAG-Mediated Transposition in Yeast by Clatworthy, Anne E., Valencia, Maria A., Haber, James E., Oettinger, Marjorie A.

“…Antigen receptor genes are assembled during lymphoid development by a specialized recombination reaction normally observed only in cells of the vertebrate…”
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