Search Results - "Clatterbuck Soper, Sarah F"
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In Vivo X-Ray Footprinting of Pre-30S Ribosomes Reveals Chaperone-Dependent Remodeling of Late Assembly Intermediates
Published in Molecular cell (21-11-2013)“…Assembly of 30S ribosomal subunits from their protein and RNA components requires extensive refolding of the 16S rRNA and is assisted by 10–20 assembly factors…”
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Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells
Published in Scientific reports (14-03-2019)“…Many tumors maintain chromosome-ends through a telomerase-independent, DNA-templated mechanism called alternative lengthening of telomeres (ALT). While ALT…”
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FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination
Published in The Journal of cell biology (03-04-2017)“…Cytoplasmic inclusions of the RNA-binding protein fused in sarcoma (FUS) represent one type of membraneless ribonucleoprotein compartment. Formation of FUS…”
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ATRX/DAXX: Guarding the Genome against the Hazards of ALT
Published in Genes (24-03-2023)“…Proliferating cells must enact a telomere maintenance mechanism to ensure genomic stability. In a subset of tumors, telomeres are maintained not by telomerase,…”
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Abstract 3467: A DAXX-KIFC3 fusion potentiates alternative lengthening of telomeres in osteosarcoma
Published in Cancer research (Chicago, Ill.) (01-07-2017)“…Proliferating cells must enact a program of telomere lengthening to counteract the chromosome end replication problem. In most types of cancer cells, telomeres…”
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