Search Results - "Clas, Sophie−Dorothee"

Lipids and polymers in pharmaceutical technology: Lifelong companions by Siepmann, Juergen, Faham, Amina, Clas, Sophie-Dorothée, Boyd, Ben J., Jannin, Vincent, Bernkop-Schnürch, Andreas, Zhao, Hang, Lecommandoux, Sébastien, Evans, James C., Allen, Christine, Merkel, Olivia M., Costabile, Gabriella, Alexander, Morgan R., Wildman, Ricky D., Roberts, Clive J., Leroux, Jean-Christophe

“…[Display omitted] In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of…”
Get full text

Correlation between Molecular Mobility and Physical Stability of Amorphous Itraconazole by Bhardwaj, Sunny P, Arora, Kapildev K, Kwong, Elizabeth, Templeton, Allen, Clas, Sophie-Dorothee, Suryanarayanan, Raj

“…The goal was to investigate the correlation between molecular mobility and physical stability in amorphous itraconazole and identify the specific mobility mode…”
Get full text

Mechanism of Amorphous Itraconazole Stabilization in Polymer Solid Dispersions: Role of Molecular Mobility by Bhardwaj, Sunny P, Arora, Kapildev K, Kwong, Elizabeth, Templeton, Allen, Clas, Sophie-Dorothee, Suryanarayanan, Raj

“…Physical instability of amorphous solid dispersions can be a major impediment to their widespread use. We characterized the molecular mobility in amorphous…”
Get full text

In Vitro Release Kinetics of Antituberculosis Drugs from Nanoparticles Assessed Using a Modified Dissolution Apparatus by Löbenberg, Raimar, Clas, Sophie-Dorothee, Pinto, Terezinha de Jesus Andreoli, Bou-Chacra, Nádia, Zuo, Jieyu, Gao, Yuan, Walker, Roderick B.

“…The aim of this study was to assess the in vitro release kinetics of antituberculosis drug-loaded nanoparticles (NPs) using a “modified” cylindrical apparatus…”
Get full text

Discovery of 2‑Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV‑1 Integrase Strand Transfer Inhibitors by Raheem, Izzat T, Walji, Abbas M, Klein, Daniel, Sanders, John M, Powell, David A, Abeywickrema, Pravien, Barbe, Guillaume, Bennet, Amrith, Clas, Sophie−Dorothee, Dubost, David, Embrey, Mark, Grobler, Jay, Hafey, Michael J, Hartingh, Timothy J, Hazuda, Daria J, Miller, Michael D, Moore, Keith P, Pajkovic, Natasa, Patel, Sangita, Rada, Vanessa, Rearden, Paul, Schreier, John D, Sisko, John, Steele, Thomas G, Truchon, Jean-François, Wai, John, Xu, Min, Coleman, Paul J

“…The search for new molecular constructs that resemble the critical two-metal binding pharmacophore required for HIV integrase strand transfer inhibition…”
Get full text

Crystallization inhibition in solid dispersions of MK-0591 and poly(vinylpyrrolidone) polymers by Khougaz, K, Clas, S D

“…The effects of poly(vinylpyrrolidone) (PVP) molecular weight, composition, and content on the crystallization of a model drug, MK-0591 (Form I), were…”
Get more information

Detection of a minor amorphous phase in crystalline etoricoxib by dynamic mechanical analysis: comparison with Raman spectroscopy and modulated differential scanning calorimetry by Clas, Sophie-Dorothee, Lalonde, Karine, Khougaz, Karine, Dalton, Chad R, Bilbeisi, Rana

“…Detection and quantification of the amorphous phase of etoricoxib bulk drug substances, a selective cycloogenase-2 inhibitor used for the treatment of…”
Get more information

Discovery of MK-8970: An Acetal Carbonate Prodrug of Raltegravir with Enhanced Colonic Absorption by Walji, Abbas M., Sanchez, Rosa I., Clas, Sophie-Dorothee, Nofsinger, Rebecca, de Lera Ruiz, Manuel, Li, Jing, Bennet, Amrithraj, John, Christopher, Bennett, David Jonathan, Sanders, John M., Di Marco, Christina N., Kim, Somang Hope, Balsells, Jaume, Ceglia, Scott S., Dang, Qun, Manser, Kimberly, Nissley, Becky, Wai, John S., Hafey, Michael, Wang, Junying, Chessen, Gene, Templeton, Allen, Higgins, John, Smith, Ronald, Wu, Yunhui, Grobler, Jay, Coleman, Paul J.

“…Developing new antiretroviral therapies for HIV‐1 infection with potential for less frequent dosing represents an important goal within drug discovery. Herein,…”
Get full text

Chemistry-enabled drug delivery (prodrugs): recent progress and challenges by Clas, Sophie-Dorothee, Sanchez, Rosa I., Nofsinger, Rebecca

“…•Prodrugs average 10% of the total number of small molecules launched in the USA.•Patent life can be extended 6–7 years by prodrugs, salts and other forms, it…”
Get full text

Design of prodrugs to enhance colonic absorption by increasing lipophilicity and blocking ionization by Nofsinger, Rebecca, Clas, Sophie-Dorothee, Sanchez, Rosa I, Walji, Abbas, Manser, Kimberly, Nissley, Becky, Balsells, Jaume, Nair, Amrithraj, Dang, Qun, Bennett, David Jonathan, Hafey, Michael, Wang, Junying, Higgins, John, Templeton, Allen, Coleman, Paul, Grobler, Jay, Smith, Ronald, Wu, Yunhui

“…Prodrugs are chemistry-enabled drug delivery modifications of active molecules designed to enhance their pharmacokinetic, pharmacodynamic and/or…”
Get full text

Hyaluronic Acid-Tocopherol Succinate-Based Self-Assembling Micelles for Targeted Delivery of Rifampicin to Alveolar Macrophages by Gao, Yuan, Sarfraz, Muhammad Khan, Clas, Sophie-Dorothee, Roa, Wilson, Löbenberg, Raimar

“…We developed a target drug delivery system for the treatment of tuberculosis using rifampicin (RIF) incorporated into hyaluronic acid-tocopherol succinate…”
Get more information

Immune response to antituberculosis drug-loaded gelatin and polyisobutyl-cyanoacrylate nanoparticles in macrophages by Sarfraz, Muhammad, Shi, Wenjun, Gao, Yuan, Clas, Sophie-Dorothee, Roa, Wilson, Bou-Chacra, Nadia, Löbenberg, Raimar

“…Secondary toxicity of nanoparticles (NPs) in macrophages is a well-known phenomenon. The aim of the study was to investigate the immuneresponse of macrophages…”
Get full text

Correction to Discovery of 2‑Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV‑1 Integrase Strand Transfer Inhibitors by Raheem, Izzat T, Walji, Abbas M, Klein, Daniel, Sanders, John M, Powell, David A, Abeywickrema, Pravien, Barbe, Guillaume, Bennet, Amrith, Childers, Karla, Christensen, Melodie, Clas, Sophie−Dorothee, Dubost, David, Embrey, Mark, Grobler, Jay, Hafey, Michael J, Hartingh, Timothy J, Hazuda, Daria J, Kuethe, Jeffrey T, McCabe Dunn, Jamie, Miller, Michael D, Moore, Keith P, Nolting, Andrew, Pajkovic, Natasa, Patel, Sangita, Peng, Zuihui, Rada, Vanessa, Rearden, Paul, Schreier, John D, Sisko, John, Steele, Thomas G, Truchon, Jean-François, Wai, John, Xu, Min, Coleman, Paul J

Get full text

Cover Picture: Discovery of MK-8970: An Acetal Carbonate Prodrug of Raltegravir with Enhanced Colonic Absorption (ChemMedChem 2/2015) by Walji, Abbas M., Sanchez, Rosa I., Clas, Sophie-Dorothee, Nofsinger, Rebecca, de Lera Ruiz, Manuel, Li, Jing, Bennet, Amrithraj, John, Christopher, Bennett, David Jonathan, Sanders, John M., Di Marco, Christina N., Kim, Somang Hope, Balsells, Jaume, Ceglia, Scott S., Dang, Qun, Manser, Kimberly, Nissley, Becky, Wai, John S., Hafey, Michael, Wang, Junying, Chessen, Gene, Templeton, Allen, Higgins, John, Smith, Ronald, Wu, Yunhui, Grobler, Jay, Coleman, Paul J.

Get full text

Micro-scale measurement of the mechanical properties of compressed pharmaceutical powders. 1: The elasticity and fracture behavior of microcrystalline cellulose by Hancock, Bruno C, Clas, Sophie-Dorothee, Christensen, Karen

“…The feasibility of using very small compacts (∼8.0×4.5×0.4 mm; ∼20 mg) to determine the elasticity and fracture behavior of compressed pharmaceutical powders…”
Get full text

Investigating the hydrate conversion propensity of different etoricoxib lots by Dalton, Chad R, Clas, Sophie-Dorothée, Singh, Jaspal, Khougaz, Karine, Bilbeisi, Rana

“…The physical stability of bulk active pharmaceutical ingredients (API) is of significant scientific and regulatory concern. Carrying out physical stability…”
Get more information

Synthesis and characterization of biodegradable and charged salen-based polymers by Nadeau, Véronique, Rabanel, Jean-Michel, Sant, Shilpa, Chahwan, Roula, Clas, Sophie-Dorothée, Hildgen, Patrice

“…The goal of this study was to synthesize novel biodegradable charged polymers for medical applications. The polymers synthesized were metal‐coordinated…”
Get full text

Differential scanning calorimetry: applications in drug development by Clas, Sophie-Dorothée, Dalton, Chad R., Hancock, Bruno C.

“…Differential scanning calorimetry (DSC) is frequently the pharmaceutical thermal analysis technique of choice because of its ability to provide detailed…”
Get full text

Evaluation of Disintegration Testing of Different Fast Dissolving Tablets Using the Texture Analyzer by El-Arini, Silvia Kocova, Clas, Sophie-Dorothée

“…The in vitro disintegration behavior of fast dissolving systems manufactured by the main commercialized technologies was studied using the texture analyzer…”
Get full text

Synthetic Lethality Targeting the Aid/RAD51 Axis for Treatment of AICDA-Expressing Lymphoma by Mills, Kevin, Cyr, Amber, Maclay, Tyler, Day, Melinda, Patrick, Darryl, Clas, Sophie-Dorothee, Hasham, Muneer G, Chow, Kin-hoe

“…Activation Induced Cytidine Deaminase (AICDA or AID) is a DNA directed cytidine deaminase that induces somatic hypermutation and immunoglobulin class switching…”
Get full text