Search Results - "Clarkson, Edward D"

Female rats are less susceptible during puberty to the lethal effects of percutaneous exposure to VX by Wright, Linnzi K M, Lee, Robyn B, Clarkson, Edward D, Lumley, Lucille A

“…Nerve agents with low volatility such as VX are primarily absorbed through the skin when released during combat or a terrorist attack. The barrier function of…”
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Butyrylcholinesterase as a therapeutic drug for protection against percutaneous VX by Lenz, David E., Clarkson, Edward D., Schulz, Susan M., Cerasoli, Douglas M.

“…The administration of purified human plasma-derived butyrylcholinesterase (HuBuChE) as a pretreatment has been demonstrated to enhance survival and protect…”
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Pro-2-PAM therapy for central and peripheral cholinesterases by DeMar, James C., Clarkson, Edward D., Ratcliffe, Ruthie H., Campbell, Amy J., Thangavelu, Sonia G., Herdman, Christine A., Leader, Haim, Schulz, Susan M., Marek, Elizabeth, Medynets, Marie A., Ku, Therese C., Evans, Sarah A., Khan, Farhat A., Owens, Roberta R., Nambiar, Madhusoodana P., Gordon, Richard K.

“…Novel therapeutics to overcome the toxic effects of organophosphorus (OP) chemical agents are needed due to the documented use of OPs in warfare (e.g…”
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Improvement of Neurological Deficits in 6-hydroxydopamine-Lesioned Rats after Transplantation with Allogeneic Simian Virus 40 Large Tumor Antigen Gene-Induced Immortalized Dopamine Cells by Clarkson, Edward D., La Rosa, Francisco G., Edwards-Prasad, Judith, Weiland, David A., Witta, Samir E., Freed, Curt R., Prasad, Kedar N.

“…The replacement of dopamine (DA) by DA neuron transplants in the treatment of advanced Parkinson disease (PD) is a rational approach. Because of limitations…”
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Median lethal dose determination for percutaneous exposure to soman and VX in guinea pigs and the effectiveness of decontamination with M291 SDK or SANDIA foam by Clarkson, Edward D., Schulz, Susan M., Railer, Roy F., Smith, Kelly H.

“…► Determined the cutaneous median lethal dose of two chemical warfare agents. ► Demonstrated the M291 kit has limited effectiveness against cutaneous VX and…”
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Somatic cell cloned transgenic bovine neurons for transplantation in parkinsonian rats by Zawada, W. Michael, Cibelli, Jose B, Choi, Paul K, Clarkson, Edward D, Golueke, Paul J, Witta, Samir E, Bell, K. Pat, Kane, Jeff, de Leon, F. Abel Ponce, Jerry, D. Joseph, Robl, James M, Freed, Curt R, Stice, Steven L

“…Parkinson's disease symptoms can be improved by transplanting fetal dopamine cells into the putamen of parkinsonian patients. Because the supply of human donor…”
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Efficacy studies of Reactive Skin Decontamination Lotion, M291 Skin Decontamination Kit, 0.5% bleach, 1% soapy water, and Skin Exposure Reduction Paste Against Chemical Warfare Agents, Part 1: Guinea pigs challenged with VX by Braue, Ernest H., Smith, Kelly H., Doxzon, Bryce F., Lumpkin, Horace L., Clarkson, Edward D.

“…Objective: This report, first in a series of five, directly compares the efficacy of 4 decontamination products and Skin Exposure Reduction Paste Against…”
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Xenografts of MHC-deficient mouse embryonic mesencephalon improve behavioral recovery in hemiparkinsonian rats by Veng, Lone M, Bjugstad, Kimberly B, Freed, Curt R, Marrack, Philippa, Clarkson, Edward D, Bell, K Patricia, Hutt, Cindy, Zawada, W Michael

“…The limited availability of human embryonic tissue for dopamine cell transplants in Parkinson's patients has led to an increased interest in using xenogeneic…”
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Efficacy studies of Reactive Skin Decontamination Lotion, M291 Skin Decontamination Kit, 0.5% bleach, 1% soapy water, and Skin Exposure Reduction Paste Against Chemical Warfare Agents, Part 2: Guinea pigs challenged with soman by Braue, Ernest H., Smith, Kelly H., Doxzon, Bryce F., Lumpkin, Horace L., Clarkson, Edward D.

“…Objective: This report, the second in a series of five, directly compares the efficacy of Reactive Skin Decontamination Lotion (RSDL), the M291 Skin…”
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Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats by Zawada, W.Michael, Zastrow, Devon J, Clarkson, Edward D, Adams, Frank S, Bell, K.Pat, Freed, Curt R

“…Embryonic dopamine neurons survive poorly after transplant into models of Parkinson's disease, possibly due to programmed cell death (apoptosis). Apoptosis in…”
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A kinetic and allosteric model for the acetylcholine transporter-vesamicol receptor in synaptic vesicles by Bahr, Ben A, Clarkson, Edward D, Rogers, Gary A, Noremberg, Krystyna, Parsons, Stanley M

“…The ligand binding relationship between the acetylcholine transporter (AcChT) and the vesamicol receptor (VR) and the kinetics of active transport were studied…”
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Fetal tissue transplantation for patients with Parkinson's disease: A database of published clinical results by CLARKSON, Edward D

“…Over the past 13 years approximately 300 patients with Parkinson's disease have received transplants of human fetal dopamine cells in an attempt to reduce or…”
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Evaluation of a Barrier Cream against the Chemical Warfare Agent VX using the Domestic White Pig by Chilcott, Robert P., Dalton, Christopher H., Hill, Ira, Davison, Corey M., Blohm, Kendal L., Clarkson, Edward D., Hamilton, Murray G.

“…: The purpose of this study was to evaluate the efficacy of a novel barrier cream formulation at reducing the percutaneous toxicity of a 2×LD50 liquid…”
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Inhibitors of p38 MAP kinase increase the survival of transplanted dopamine neurons by Michael Zawada, W., Meintzer, Mary K., Rao, Pravin, Marotti, Jonathan, Wang, Xiaomin, Esplen, James E., Clarkson, Edward D., Freed, Curt R., Heidenreich, Kim A.

“…Fetal cell transplantation therapies are being developed for the treatment of a number of neurodegenerative disorders including Parkinson’s disease…”
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IGF-I and bFGF Improve Dopamine Neuron Survival and Behavioral Outcome in Parkinsonian Rats Receiving Cultured Human Fetal Tissue Strands by Clarkson, Edward D., Zawada, W.Michael, Bell, K.Pat, Esplen, James E., Choi, Paul K., Heidenreich, Kim A., Freed, Curt R.

“…To promote dopamine cell survival in human fetal tissue strands transplanted into immunosuppressed 6-OHDA-lesioned rats, we have preincubated tissue in…”
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Reactive Skin Decontamination Lotion (RSDL) Maintains Its Effectiveness against Cutaneous Applications of VX Nerve Agent for at Least 5 Years Past Its Expiration Date by Clarkson, Edward D., Morgan, Julia E., Chen, Paul, Schultz, Susan M., Soni, Sunil D., Capacio, Benedict R., Koplovitz, Irwin

“…Reactive Skin Decontamination Lotion (RSDL) is the primary product the US military has fielded to decontaminate cutaneous exposures to chemical warfare agents…”
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Effective GC-MS procedure for detecting iso-LSD in urine after base-catalyzed conversion to LSD by Clarkson, Edward D, Lesser, David, Paul, Buddha D

“…A sensitive method is described to detect isolysergic acid diethylamide (iso-LSD) in urine. The compound was extracted from urine and converted to a C-8…”
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Brain contains inhibiting factors specific to the large T-antigen gene by Clarkson, Edward D, La Rosa, Francisco G, Edwards-Prasad, Judith, Kumar, Sanjay, Kumar, Arun, Cole, William, Freed, Curt R, Prasad, Kedar N

“…SV40 large T-antigen (LTa) gene-induced immortalized rat dopamine-producing nerve cells (1RB 3AN 27), which produce LTa protein and divide in vitro, do not…”
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Fetal Tissue Transplantation for Patients with Parkinson??s Disease: A Database of Published Clinical Results by Clarkson, Edward D.

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GDNF improves survival and reduces apoptosis in human embryonic dopaminergic neurons in vitro by Clarkson, E D, Zawada, W M, Freed, C R

“…Dopamine cell death is the primary problem limiting the value of neurotransplantation in human patients with Parkinson's disease. To address this problem, we…”
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