Search Results - "Clarkson, C W"

Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from block during diastole by CLARKSON, C. W, HONDEGHEM, L. M

“…The effects of bupivacaine and lidocaine on cardiac conduction were compared in guinea pig ventricular muscle. Membrane potential was controlled using a single…”
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Cocaethylene, a metabolite of cocaine and ethanol, is a potent blocker of cardiac sodium channels by Xu, Y Q, Crumb, Jr, W J, Clarkson, C W

“…Cocaethylene is an active metabolite of cocaine believed to play a causative role in the increased incidence of sudden death in individuals who coadminister…”
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Characterization of the sodium channel blocking properties of the major metabolites of cocaine in single cardiac myocytes by Crumb, Jr, W J, Clarkson, C W

“…Clinical reports indicate that almost 30% of cocaine overdose-related deaths occur 2 to 5 hr after administration, when an appreciable amount of cocaine can be…”
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Evidence for a Specific Receptor Site for Lidocaine, Quinidine, and Bupivacaine Associated with Cardiac Sodium Channels in Guinea Pig Ventricular Myocardium by Clarkson, Craig W, Hondeghem, Luc M

“…According to the modulated receptor hypothesis, sodium channels have a specific receptor site for local anesthetic and antiarrhythmic drugs. Thus, in the…”
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The pH dependence of cocaine interaction with cardiac sodium channels by Crumb, Jr, W J, Clarkson, C W

“…Previous in vitro and in vivo studies have provided evidence implicating cocaine block of cardiac sodium channels as a putative mechanism for cocaine-induced…”
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Quinidine Interactions With Human Atrial Potassium Channels: Developmental Aspects by Nenov, Neviana I, Crumb, William J, Pigott, John D, Harrison, Lynn H, Clarkson, Craig W

“…Clinical studies have suggested that quinidine is less effective when used for the treatment of atrial arrhythmias in pediatric patients compared with its…”
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Evidence for Two Components of Sodium Channel Block by Lidocaine in Isolated Cardiac Myocytes by Clarkson, C W, Follmer, C H, Eick, R.E Ten, Hondeghem, L M, Yeh, J Z

“…The effects of lidocaine on sodium current in cardiac myocytes isolated from cat and guinea pig were investigated using the whole-cell variation of the…”
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Evidence for Developmental Changes in Sodium Channel Inactivation Gating and Sodium Channel Block by Phenytoin in Rat Cardiac Myocytes by Xu, You-Qiu, Pickoff, Arthur S, Clarkson, Craig W

“…The voltage-dependent properties of the voltage-activated sodium channel were studied in neonatal (1–2-day-old) and adult rat ventricular cardiac myocytes…”
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Stereoselective Block of Cardiac Sodium Channels by RAC109 in Single Guinea Pig Ventricular Myocytes by Clarkson, Craig W

“…The effects of the optical stereoisomers of the local anesthetic RAC109 (RAC109-I and RAC109-II) on sodium current in isolated guinea pig ventricular myocytes…”
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Description of a Nonselective Cation Current in Human Atrium by Crumb, Jr, Pigott, John D, Clarkson, Craig W

“…Ion currents were examined in isolated human atrial myocytes by using the whole-cell patch-clamp technique. When currents were recorded with a K-containing…”
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Characterization of cocaine-induced block of cardiac sodium channels by Crumb, W.J., Clarkson, C.W.

“…Recent evidence suggests that cocaine can produce marked cardiac arrhythmias and sudden death. A possible mechanism for this effect is slowing of impulse…”
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Developmental changes in the effects of lidocaine on sodium channels in rat cardiac myocytes by Xu, Y Q, Pickoff, A S, Clarkson, C W

“…Previous studies have suggested that there are developmental changes in the sodium channel blocking properties of class I antiarrhythmic drugs, yet this…”
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On the Mechanism of Lysophosphatidylcholine-Induced Depolarization of Cat Ventricular Myocardium by Clarkson, Craig W, Ten Eick, Robert E

“…Lysophosphatidylcholine, a putative biochemical mediator of ischemia-induced arrhythmias, reduces the resting potential of ventricular muscle. To elucidate…”
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L-type calcium current in pediatric and adult human atrial myocytes : Evidence for developmental changes in channel inactivation by ROCA, T. P, PIGOTT, J. D, CLARKSON, C. W, CRUMB, W. J

“…Animal studies have documented the presence of marked, species-dependent, developmental changes in the properties of the L-type calcium current in cardiac…”
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Effects of cocaine and its major metabolites on the HERG-encoded potassium channel by Ferreira, S, Crumb, Jr, W J, Carlton, C G, Clarkson, C W

“…Cocaine abuse has been reported to result in QT prolongation in humans; however, the mechanisms underlying this effect are still poorly understood. In this…”
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Rate-dependent effects of lidocaine on His-Purkinje conduction in the intact neonatal heart--characterization and amplification by N-acetylprocainamide by Dise, T L, Stolfi, A, Clarkson, C W, Pickoff, A S

“…According to mathematical models of antiarrhythmic drug-receptor interactions, lidocaine binds preferentially to the sodium channel when the membrane is…”
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Comparison of Ito in young and adult human atrial myocytes: evidence for developmental changes by Crumb, Jr, W J, Pigott, J D, Clarkson, C W

“…In an effort to understand the ionic basis for the developmental changes that have been reported to occur in the configuration of the human atrial action…”
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Electrophysiological effects of high cocaine concentrations on intact canine heart : evidence for modulation by both heart rate and autonomic nervous system by CLARKSON, C. W, CHUNTONG CHANG, STOLFI, A, GEORGE, W. J, YAMASAKI, S, PICKOFF, A. S

“…Previous clinical reports have suggested that cocaine intoxication may produce severe ventricular arrhythmias due to a direct effect on the heart. However, the…”
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Characterization of the rate-dependent effects of ethmozine on conduction, in vivo, and on the sodium current, in vitro, in the newborn heart by Liu, W, Clarkson, C W, Yamasaki, S, Chang, C, Stolfi, A, Pickoff, A S

“…We evaluated the effects of ethmozine on resting conduction intervals, myocardial refractory periods and His-Purkinje and intraventricular conduction in vivo…”
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Modification of Na channel inactivation by α-chymotrypsin in single cardiac myocytes by CLARKSON, C. W

“…The effects of alpha-chymotrypsin and trypsin on the macroscopic Na current in isolated guinea pig ventricular myocytes at 16 degrees C were investigated using…”
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