Search Results - "Clarke, William P"

Making Sense of Pharmacology: Inverse Agonism and Functional Selectivity by Berg, Kelly A, Clarke, William P

“…Constitutive receptor activity/inverse agonism and functional selectivity/biased agonism are 2 concepts in contemporary pharmacology that have major…”
Get full text

Functional selectivity and classical concepts of quantitative pharmacology by Urban, Jonathan D, Clarke, William P, von Zastrow, Mark, Nichols, David E, Kobilka, Brian, Weinstein, Harel, Javitch, Jonathan A, Roth, Bryan L, Christopoulos, Arthur, Sexton, Patrick M, Miller, Keith J, Spedding, Michael, Mailman, Richard B

“…The concept of intrinsic efficacy has been enshrined in pharmacology for half of a century, yet recent data have revealed that many ligands can differentially…”
Get more information

Atypical antipsychotics and inverse agonism at 5-HT2 receptors by Sullivan, Laura C, Clarke, William P, Berg, Kelly A

“…It is now well accepted that receptors can regulate cellular signaling pathways in the absence of a stimulating ligand, and inverse agonists can reduce this…”
Get more information

Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy by LoCoco, Peter M, Risinger, April L, Smith, Hudson R, Chavera, Teresa S, Berg, Kelly A, Clarke, William P

“…Chemotherapy-induced peripheral neuropathy (CIPN) arises from collateral damage to peripheral afferent sensory neurons by anticancer pharmacotherapy, leading…”
Get full text

Fine-tuning serotonin2c receptor function in the brain: molecular and functional implications by Berg, Kelly A, Clarke, William P, Cunningham, Kathryn A, Spampinato, Umberto

“…The serotonin(2C) receptor (5-HT(2C)R) is a member of the serotonin(2) family of 7-transmembrane-spanning (7-TMS) receptors, which possesses unique molecular…”
Get full text

Long‐term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox by Zamora, Joshua C., Smith, Hudson R., Jennings, Elaine M., Chavera, Teresa S., Kotipalli, Varun, Jay, Aleasha, Husbands, Stephen M., Disney, Alex, Berg, Kelly A., Clarke, William P.

“…Opioid overdose is a leading cause of death in the United States. The only treatment available currently is the competitive antagonist, naloxone (Narcan®)…”
Get full text

Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors by Moya, Pablo R, Berg, Kelly A, Gutiérrez-Hernandez, Manuel A, Sáez-Briones, Patricio, Reyes-Parada, Miguel, Cassels, Bruce K, Clarke, William P

“…2,5-Dimethoxy-4-substituted phenylisopropylamines and phenethylamines are 5-hydroxytryptamine (serotonin) (5-HT)(2A/2C) agonists. The former are partial to…”
Get more information

Physiological relevance of constitutive activity of 5-HT2A and 5-HT2C receptors by Berg, Kelly A, Harvey, John A, Spampinato, Umberto, Clarke, William P

“…It is generally accepted that seven-transmembrane receptors have the capacity to regulate cellular signaling systems in the absence of occupancy by a ligand…”
Get full text

A conservative, single-amino acid substitution in the second cytoplasmic domain of the human Serotonin2C receptor alters both ligand-dependent and -independent receptor signaling by Berg, Kelly A, Dunlop, John, Sanchez, Teresa, Silva, Michelle, Clarke, William P

“…The post-transcriptional process of mRNA editing changes up to three amino acids in the second intracellular domain (i2) of the serotonin(2C) (5-HT(2C))…”
Get more information

Structure of a cellulose degrading bacterial community during anaerobic digestion by O'Sullivan, C.A, Burrell, P.C, Clarke, W.P, Blackall, L.L

“…It is widely accepted that cellulose is the rate-limiting substrate in the anaerobic digestion of organic solid wastes and that cellulose solubilisation is…”
Get full text

Concurrent microscopic observations and activity measurements of cellulose hydrolyzing and methanogenic populations during the batch anaerobic digestion of crystalline cellulose by Song, H, Clarke, W.P, Blackall, L.L

“…This study compares process data with microscopic observations from an anaerobic digestion of organic particles. As the first part of the study, this article…”
Get full text

Transition of microbial communities and degradation pathways in anaerobic digestion at decreasing retention time by Peces, Miriam, Astals, Sergi, Jensen, Paul D., Clarke, William P.

“…•Decrease in hydraulic retention time (HRT) at a constant organic loading rate (OLR) led to microbiome shifts but not washout.•Methanosaeta relative abundance…”
Get full text

Organic waste biorefineries: Looking towards implementation by Alibardi, Luca, Astrup, Thomas F., Asunis, Fabiano, Clarke, William P., De Gioannis, Giorgia, Dessì, Paolo, Lens, Piet N.L., Lavagnolo, Maria Cristina, Lombardi, Lidia, Muntoni, Aldo, Pivato, Alberto, Polettini, Alessandra, Pomi, Raffaella, Rossi, Andreina, Spagni, Alessandro, Spiga, Daniela

“…•Organic waste biorefinery is a concept for waste management.•Biorefineries can extract high value products from organic waste.•The heterogeneity of waste…”
Get full text

Bioremediation for Acid Mine Drainage: Organic Solid Waste as Carbon Sources For Sulfate-Reducing Bacteria: A Review by Jamil, I. N., Clarke, William P.

“…Biological sulfate reduction has been slowly replacing chemical unit processes to treat acid mine drainage (AMD). Bioremediations for AMD treatment are favored…”
Get full text

Characterization of Buprenorphine Antagonism at Human Mu Opioid Receptors by Wedemeyer, Michael J., Berg, Kelly A., Clarke, William P.

“…In 2017 the US government declared a public health emergency to address the national opioid crisis. Despite this focused effort and increased awareness, opioid…”
Get full text

Rapid digestion of shredded MSW by sequentially flooding and draining small landfill cells by Clarke, William P., Xie, Sihuang, Patel, Miheka

“…•Two 1000t beds of sub-8cm shredded MSW were digested by flooding and draining with landfill leachate.•A 1974t bed of the same material was digested by…”
Get full text

RNA‐editing of the 5‐HT2C receptor alters agonist‐receptor‐effector coupling specificity by Berg, Kelly A, Cropper, Jodie D, Niswender, Colleen M, Sanders‐Bush, Elaine, Emeson, Ronald B, Clarke, William P

“…The serotonin2C (5‐HT2C) receptor couples to both phospholipase C (PLC)‐inositol phosphate (IP) and phospholipase A2 (PLA2)‐arachidonic acid (AA) signalling…”
Get full text

Comparison of cellulose solubilisation rates in rumen and landfill leachate inoculated reactors by O’Sullivan, Cathryn A., Burrell, Paul C., Clarke, William P., Blackall, Linda L.

“…The aim of this study was to conduct a number of controlled digestions to obtain easily comparable cellulose solubilisation rates and to compare these rates to…”
Get full text

What's for lunch at the conformational cafeteria? by Clarke, William P

“…In this issue of Molecular Pharmacology, Mukhopadhyay and Howlett present evidence for ligand-selective conformations of the CB1 cannabinoid receptor with…”
Get more information

Ligand‐Dependent Reversal Kinetics of Mu Opioid Receptor Agonists by the Novel Antagonist, Methocinnamox by Smith, Hudson R., Chavera, Teresa S., Berg, Kelly A., Clarke, William P.

“…Naloxone (NLX) is a competitive antagonist at the mu opioid receptor and is currently the only pharmacological intervention available to treat an opioid…”
Get full text