Search Results - "Clarke, Simon R"

In Vitro Antibacterial Activity of Unconjugated and Conjugated Bile Salts on Staphylococcus aureus by Sannasiddappa, Thippeswamy H, Lund, Peter A, Clarke, Simon R

“…Bile salts are potent antimicrobial agents and are an important component of innate defenses in the intestine, giving protection against invasive organisms…”
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Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling by Lopes Pires, Maria E, Clarke, Simon R, Marcondes, Sisi, Gibbins, Jonathan M

“…Lipopolysaccharide (LPS) from the cell envelope of Gram-negative bacteria is a principal cause of the symptoms of sepsis. LPS has been reported to modulate the…”
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IsdA Protects Staphylococcus aureus against the Bactericidal Protease Activity of Apolactoferrin by Clarke, Simon R, Foster, Simon J

“…An important facet of the Staphylococcus aureus host-pathogen interaction is the ability of the invading bacterium to evade host innate defenses, particularly…”
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The influence of Staphylococcus aureus on gut microbial ecology in an in vitro continuous culture human colonic model system by Sannasiddappa, Thippeswamy H, Costabile, Adele, Gibson, Glenn R, Clarke, Simon R

“…An anaerobic three-stage continuous culture model of the human colon (gut model), which represent different anatomical areas of the large intestine, was used…”
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Evaluation of efflux pump inhibitory activity of some plant extracts and using them as adjuvants to potentiate the inhibitory activity of some antibiotics against Staphylococcus aureus by Al-Sallami, Dhama, Alsultan, Amjed, Abbas, Kadhim Hassan, Clarke, Simon R

“…Antibiotic-resistant pathogens became a real global threat to human and animal health. This needs to concentrate the efforts to minimize and control these…”
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Activation of Human Platelets by Staphylococcus aureus Secreted Protease Staphopain A by Waller, Amie K., Birch, Katie, Gibbins, Jonathan M., Clarke, Simon R.

“…Infection by Staphylococcus aureus is the leading cause of infective endocarditis (IE). Activation of platelets by this pathogen results in their aggregation…”
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Iron-Regulated Surface Determinant Protein A Mediates Adhesion of Staphylococcus aureus to Human Corneocyte Envelope Proteins by Clarke, Simon R, Andre, Guillaume, Walsh, Evelyn J, Dufrêne, Yves F, Foster, Timothy J, Foster, Simon J

“…The ability of Staphylococcus aureus to colonize the human nares is a crucial prerequisite for disease. IsdA is a major S. aureus surface protein that is…”
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Identification of In Vivo–Expressed Antigens of Staphylococcus aureus and Their Use in Vaccinations for Protection against Nasal Carriage by Clarke, Simon R., Brummell, Kirsten J., Horsburgh, Malcolm J., McDowell, Philip W., Mohamad, Sharifah A. Syed, Stapleton, Melanie R., Acevedo, Jorge, Read, Robert C., Day, Nicholas P. J., Peacock, Sharon J., Mond, James J., Kokai-Kun, John F., Foster, Simon J.

“…A spectrum of in vivo–expressed Staphylococcus aureus antigens was identified by probing bacteriophage expression libraries of S. aureus with serum samples…”
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Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC by Jensen, Rasmus O., Winzer, Klaus, Clarke, Simon R., Chan, Weng C., Williams, Paul

“…Virulence in Staphylococcus aureus is regulated via agr-dependent quorum sensing in which an autoinducing peptide (AIP) activates AgrC, a histidine protein…”
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IsdA of Staphylococcus aureus is a broad spectrum, iron‐regulated adhesin by Clarke, Simon R., Wiltshire, Michael D., Foster, Simon J.

“…Summary As an important facet of host–pathogen interaction, Staphylococcus aureus has the ability to adhere to human extracellular matrix (ECM) components via…”
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Staphylococcus aureus FadB is a dehydrogenase that mediates cholate resistance and survival under human colonic conditions by Alsultan, Amjed, Walton, Gemma, Andrews, Simon C, Clarke, Simon R

“…is a common colonizer of the human gut and in doing so it must be able to resist the actions of the host's innate defences. Bile salts are a class of molecules…”
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A fast, spectrally accurate homotopy based numerical method for solving nonlinear differential equations by Cullen, Andrew C., Clarke, Simon R.

“…•Documentation of a new nonlinear solver for boundary value problems.•Exploration of theoretical scaling.•Experimental validation of scaling…”
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Analysis of Ebh, a 1.1-Megadalton Cell Wall-Associated Fibronectin-Binding Protein of Staphylococcus aureus by CLARKE, Simon R, HARRIS, Llinos G, RICHARDS, R. Geoff, FOSTER, Simon J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Identification of Antigenic Components of Staphylococcus epidermidis Expressed during Human Infection by Pourmand, Mohammad R, Clarke, Simon R, Schuman, Richard F, Mond, James J, Foster, Simon J

“…A spectrum of in vivo-expressed Staphylococcus epidermidis antigens was identified by probing a bacteriophage lambda library of S. epidermidis genomic DNA with…”
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Targeting Staphylococcus aureus Quorum Sensing with Nonpeptidic Small Molecule Inhibitors by Murray, Ewan J, Crowley, Rebecca C, Truman, Alex, Clarke, Simon R, Cottam, James A, Jadhav, Gopal P, Steele, Victoria R, O’Shea, Paul, Lindholm, Catharina, Cockayne, Alan, Chhabra, Siri Ram, Chan, Weng C, Williams, Paul

“…A series of 3-oxo-C12-HSL, tetramic acid, and tetronic acid analogues were synthesized to gain insights into the structural requirements for quorum sensing…”
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Surface adhesins of Staphylococcus aureus by Clarke, Simon R, Foster, Simon J

“…An important facet in the interaction between Staphylococcus aureus and its host is the ability of the bacterium to adhere to human extracellular matrix…”
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The Staphylococcus aureus surface protein IsdA mediates resistance to innate defenses of human skin by Clarke, Simon R, Mohamed, Ramlan, Bian, Li, Routh, Alexander F, Kokai-Kun, John F, Mond, James J, Tarkowski, Andrej, Foster, Simon J

“…Resistance to human skin innate defenses is crucial for survival and carriage of Staphylococcus aureus, a common cutaneous pathogen and nasal colonizer. Free…”
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Bacterial pathogen evolution: breaking news by Jackson, Robert W, Johnson, Louise J, Clarke, Simon R, Arnold, Dawn L

“…The immense social and economic impact of bacterial pathogens, from drug-resistant infections in hospitals to the devastation of agricultural resources, has…”
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Phenol-soluble modulins of Staphylococcus aureus lure neutrophils into battle by Clarke, Simon R

“…Epidemics of community-acquired Staphylococcus aureus are caused by strains producing high concentrations of phenol-soluble modulins (PSMs). How neutrophils…”
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Staphylococcus aureus Lipoteichoic Acid Inhibits Platelet Activation and Thrombus Formation via the Paf Receptor by Waller, Amie K., Sage, Tanya, Kumar, Christopher, Carr, Thomas, Gibbins, Jonathan M., Clarke, Simon R.

“…Impaired healing is common in wounds infected with the major human pathogen Staphylococcus aureus, although the underlying mechanisms are poorly understood…”
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