Search Results - "Clarke, Jane J"
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Summary of in vitro genetic toxicology assay results: Expected and unexpected effects of recent study design modifications
Published in Environmental and molecular mutagenesis (01-10-2012)“…Key modifications to in vitro genetic toxicology testing have been made in the last 5 years including the use of optimization approaches such as…”
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Evaluation of the butter flavoring chemical diacetyl and a fluorochemical paper additive for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells
Published in Food and chemical toxicology (01-08-2008)“…Diacetyl (2,3-butanedione) is a yellowish liquid that is usually mixed with other ingredients to produce butter flavor or other flavors in a variety of food…”
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Mutagenicity of chromium picolinate and its components in Salmonella typhimurium and L5178Y mouse lymphoma cells
Published in Food and chemical toxicology (01-11-2005)“…Chromium picolinate is one of the most commonly used chromium dietary supplements available in the United States, and it has been marketed to consumers for use…”
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Lack of mutagenicity of chromium picolinate in the hypoxanthine phosphoribosyltransferase gene mutation assay in Chinese hamster ovary cells
Published in Mutation research (01-08-2005)“…Chromium picolinate (CrPic, Chromax ®) is a dietary supplement that is stable and more bioavailable than other commercially available forms of chromium…”
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Chromium picolinate does not produce chromosome damage in CHO cells
Published in Mutation research (10-11-2005)“…Chromium picolinate (CrPic, Chromax ®) is a dietary supplement that has been commercially available for the past two decades. CrPic has potential benefits for…”
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Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells
Published in Food and chemical toxicology (2008)“…Kava ( Piper methysticum) is a member of the pepper family and has been cultivated by South Pacific islanders for centuries and used as a social and ceremonial…”
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Non-coplanar 2,2′,3,3′,4,4′,5,5′,6,6′-decachlorobiphenyl (PCB 209) did not induce cytochrome P450 enzyme activities in primary cultured rat hepatocytes, was not genotoxic, and did not exhibit endocrine-modulating activities
Published in Toxicology (Amsterdam) (31-01-2009)“…Abstract 2,2′,3,3′,4,4′,5,5′,6,6′-Decachlorobiphenyl (PCB 209) is a fully chlorinated, non-coplanar biphenyl. To demonstrate that PCB 209 is not likely to…”
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Re-evaluation of the mutagenic potential of quinacrine dihydrochloride dihydrate
Published in Mutation research (25-07-2001)“…Quinacrine has been used for voluntary female non-surgical sterilization for its ability to produce tubal occlusion. Safety issues regarding quinacrine have…”
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Genotoxicity of iron chelators in L5178Y mouse lymphoma cells
Published in Environmental and molecular mutagenesis (2001)“…To further study the mechanism of observed iron mutagenicity and cellular toxicity, a number of different iron chelators were evaluated to select a compound…”
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Evaluating kava extracts and kavalactones for mutagenicity and toxicity
Published in The FASEB journal (01-03-2008)“…Abstract only Kava ( Piper methysticum ) has been cultivated by South Pacific islanders for centuries and used as a social and ceremonial drink. The active…”
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Comparison of mutagenic responses in the L5178Y/tk(+/-) mouse lymphoma assay using old and new evaluation criteria
Published 01-01-2002“…The National Cancer Institute (NCI) shares the responsibility for selecting the majority of the most significant chemicals for carcinogenicity testing by the…”
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Dissertation
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