Search Results - "Clarke, Ian N."

Evolution of Chlamydia trachomatis by Clarke, Ian N.

“…We know surprisingly little about the evolutionary origins of Chlamydia trachomatis. It causes both ocular (trachoma) and sexually transmitted infections in…”
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Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector by Wang, Yibing, Kahane, Simona, Cutcliffe, Lesley T, Skilton, Rachel J, Lambden, Paul R, Clarke, Ian N

“…Chlamydia trachomatis remains one of the few major human pathogens for which there is no transformation system. C. trachomatis has a unique obligate…”
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Diversity in Chlamydial plasmids by Szabo, Kolos V, O'Neill, Colette E, Clarke, Ian N

“…Evolutionary studies have been conducted that have investigated the chromosomal variance in the genus of Chlamydia. However, no all-encompassing genus-wide…”
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High-resolution genotyping of Lymphogranuloma Venereum (LGV) strains of Chlamydia trachomatis in London using multi-locus VNTR analysis-ompA genotyping (MLVA-ompA) by Manning, Chloe, O'Neill, Colette, Clarke, Ian N, Rebec, Monica, Cliff, Penelope R, Marsh, Peter

“…Lymphogranuloma venereum (LGV) is caused by Chlamydia trachomatis strains with ompA genotypes L1 to L3. An LGV epidemic associated with the L2b genotype has…”
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Quantitative Proteomics of the Infectious and Replicative Forms of Chlamydia trachomatis by Skipp, Paul J S, Hughes, Chris, McKenna, Thérèse, Edwards, Richard, Langridge, James, Thomson, Nicholas R, Clarke, Ian N

“…The obligate intracellular developmental cycle of Chlamydia trachomatis presents significant challenges in defining its proteome. In this study we have applied…”
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The Swedish new variant of Chlamydia trachomatis by Unemo, Magnus, Clarke, Ian N

“…PURPOSE OF REVIEWThis review focuses on the anatomy of the Swedish new variant of Chlamydia trachomatis (nvCT). This information provides an interesting…”
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The Structure of Spiroplasma Virus 4 : Exploring the Capsid Diversity of the Microviridae by Mietzsch, Mario, Kailasan, Shweta, Bennett, Antonette, Chipman, Paul, Fane, Bentley, Huiskonen, Juha T, Clarke, Ian N, McKenna, Robert

“…(SpV4) is a bacteriophage of the , which packages circular ssDNA within non-enveloped T = 1 icosahedral capsids. It infects spiroplasmas, which are known…”
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Infection of Calves with Bovine Norovirus GIII.1 Strain Jena Virus: an Experimental Model To Study the Pathogenesis of Norovirus Infection by Otto, Peter H., Clarke, Ian N., Lambden, Paul R., Salim, Omar, Reetz, Jochen, Liebler-Tenorio, Elisabeth M.

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages by Andersson, Patiyan, Harris, Simon R., Smith, Helena M. B. Seth, Hadfield, James, O’Neill, Colette, Cutcliffe, Lesley T., Douglas, Fiona P., Asche, L. Valerie, Mathews, John D., Hutton, Susan I., Sarovich, Derek S., Tong, Steven Y. C., Clarke, Ian N., Thomson, Nicholas R., Giffard, Philip M.

“…Chlamydia trachomatis causes sexually transmitted infections and the blinding disease trachoma. Current data on C. trachomatis phylogeny show that there is…”
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Genetic transformation of a clinical (genital tract), plasmid-free isolate of Chlamydia trachomatis: engineering the plasmid as a cloning vector by Wang, Yibing, Kahane, Simona, Cutcliffe, Lesley T, Skilton, Rachel J, Lambden, Paul R, Persson, Kenneth, Bjartling, Carina, Clarke, Ian N

“…Our study had three objectives: to extend the plasmid-based transformation protocol to a clinical isolate of C. trachomatis belonging to the trachoma biovar,…”
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Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the developmental cycle by Skilton, Rachel J, Cutcliffen, Lesley T, Barlow, David, Wang, Yibing, Salim, Omar, Lambden, Paul R, Clarke, Ian N

“…Chlamydia trachomatis is a major human pathogen with a unique obligate intracellular developmental cycle that takes place inside a modified cytoplasmic…”
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Expression of the murine norovirus (MNV) ORF1 polyprotein is sufficient to induce apoptosis in a virus-free cell model by Herod, Morgan R, Salim, Omar, Skilton, Rachel J, Prince, Cynthia A, Ward, Vernon K, Lambden, Paul R, Clarke, Ian N

“…Investigations into human norovirus infection, replication and pathogenesis, as well as the development of potential antiviral agents, have been restricted by…”
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Progress towards an inducible, replication-proficient transposon delivery vector for Chlamydia trachomatis by Skilton, Rachel J, O'Neill, Colette, Thomson, Nicholas R, Lampe, David J, Clarke, Ian N

“…Genetic systems have been developed for but the extremely low transformation frequency remains a significant bottleneck.  Our goal is to develop a…”
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An inducible transposon mutagenesis approach for the intracellular human pathogen Chlamydia trachomatis by O'Neill, Colette E, Skilton, Rachel J, Forster, Jade, Cleary, David W, Pearson, Sarah A, Lampe, David J, Thomson, Nicholas R, Clarke, Ian N

“…is a prolific human pathogen that can cause serious long-term conditions if left untreated. Recent developments in genetics have opened the door to conducting…”
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Structure-based design and functional studies of novel noroviral 3C protease chimaeras offer insights into substrate specificity by Herod, Morgan R, Prince, Cynthia A, Skilton, Rachel J, Ward, Vernon K, Cooper, Jonathan B, Clarke, Ian N

“…The norovirus NS6 protease is a key target for anti-viral drug development. Noroviruses encode a 2200 amino acid polyprotein which is cleaved by this critical…”
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Co-evolution of genomes and plasmids within Chlamydia trachomatis and the emergence in Sweden of a new variant strain by Seth-Smith, Helena M B, Harris, Simon R, Persson, Kenneth, Marsh, Pete, Barron, Andrew, Bignell, Alexandra, Bjartling, Carina, Clark, Louise, Cutcliffe, Lesley T, Lambden, Paul R, Lennard, Nicola, Lockey, Sarah J, Quail, Michael A, Salim, Omar, Skilton, Rachel J, Wang, Yibing, Holland, Martin J, Parkhill, Julian, Thomson, Nicholas R, Clarke, Ian N

“…Chlamydia trachomatis is the most common cause of sexually transmitted infections globally and the leading cause of preventable blindness in the developing…”
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The Nature and Extent of Plasmid Variation in Chlamydia trachomatis by Jones, Charlotte A, Hadfield, James, Thomson, Nicholas R, Cleary, David W, Marsh, Peter, Clarke, Ian N, O'Neill, Colette E

“…is an obligate intracellular pathogen of humans, causing both the sexually transmitted infection, chlamydia, and the most common cause of infectious blindness,…”
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Inherent structural disorder and dimerisation of murine norovirus NS1-2 protein by Baker, Estelle S, Luckner, Sylvia R, Krause, Kurt L, Lambden, Paul R, Clarke, Ian N, Ward, Vernon K

“…Human noroviruses are highly infectious viruses that cause the majority of acute, non-bacterial epidemic gastroenteritis cases worldwide. The first open…”
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Recovery of infectious murine norovirus using pol II-driven expression of full-length cDNA by Ward, Vernon K, McCormick, Christopher J, Clarke, Ian N, Salim, Omar, Wobus, Christiane E, Thackray, Larissa B, Virgin, Herbert W. IV, Lambden, Paul R

“…Noroviruses are the major cause of nonbacterial gastroenteritis in humans. These viruses have remained refractory to detailed molecular studies because of the…”
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The effect of penicillin on Chlamydia trachomatis DNA replication by Lambden, Paul R, Pickett, Mark A, Clarke, Ian N

“…Molecular Microbiology Group, University of Southampton Medical School, MP814, Southampton General Hospital, Hampshire SO16 6YD, UK Correspondence Ian N…”
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