Search Results - "Clarke, IJ"

Evidence for estrogenic regulation of gonadotropin-releasing hormone neurons by glutamatergic neurons in the ewe brain: An immunohistochemical study using an antibody against vesicular glutamate transporter-2 by Pompolo, Sueli, Pereira, Alda, Scott, Christopher James, Fujiyma, Fumino, Clarke, Iain James

“…Gonadotropin‐releasing hormone (GnRH) secretion is controlled by various factors, including the excitatory neurotransmitter glutamate. Estrogen (E) regulates…”
Get full text

Seasonal Changes in the Inputs to Gonadotropin-Releasing Hormone Neurones in the Ewe Brain: An Assessment by Conventional Fluorescence and Confocal Microscopy by Pompolo, S., Pereira, A., Kaneko, T., Clarke, I. J.

“…The seasonal pattern of breeding in sheep offers an opportunity to examine plasticity of neuronal inputs to gonadotropin‐releasing hormone (GnRH) neurones. We…”
Get full text

Intracerebroventricular infusion of leptin elevates the secretion of luteinising hormone without affecting food intake in long-term food-restricted sheep, but increases growth hormone irrespective of bodyweight by Henry, BA, Goding, JW, Tilbrook, AJ, Dunshea, FR, Clarke, IJ

“…Leptin can act as a satiety factor and exert neuroendocrine effects, but most studies have been performed in fasted animals. We aimed to determine the effect…”
Get full text

Characterisation of the rapid release of activin A following acute lipopolysaccharide challenge in the ewe by Jones, KL, de Kretser, DM, Clarke, IJ, Scheerlinck, JP, Phillips, DJ

“…A series of experiments were conducted in adult ewes to delineate the release profile of activin A and its relationship to other cytokines following an i.v…”
Get full text

Influence of sex and gonadal status of sheep on cortisol secretion in response to ACTH and on cortisol and LH secretion in response to stress: importance of different stressors by Turner, AI, Canny, BJ, Hobbs, RJ, Bond, JD, Clarke, IJ, Tilbrook, AJ

“…There are sex differences in the response to stress and in the influence of stress on reproduction which may be due to gonadal steroids but the nature of these…”
Get full text

Effect of gonadotropin‐inhibitory hormone on luteinizing hormone secretion in humans by George, J.T., Hendrikse, M., Veldhuis, J.D., Clarke, I.J., Anderson, R.A., Millar, R.P.

“…Summary Background Gonadotropin‐inhibitory hormone (GnIH, human homologue of RFRP‐3) suppresses gonadotropin secretion in animal models, but its effects have…”
Get full text

Sexual dimorphism of the somatotrophic axis by Gatford, KL, Egan, AR, Clarke, IJ, Owens, PC

Get full text

Suppression of the secretion of luteinizing hormone due to isolation/restraint stress in gonadectomised rams and ewes is influenced by sex steroids by Tilbrook, AJ, Canny, BJ, Serapiglia, MD, Ambrose, TJ, Clarke, IJ

“…In this study we used an isolation/restraint stress to test the hypothesis that stress will affect the secretion of LH differently in gonadectomised rams and…”
Get full text

Effects of Central Infusion of Ghrelin on Food Intake and Plasma Levels of Growth Hormone, Luteinizing Hormone, Prolactin, and Cortisol Secretion in Sheep by Iqbal, Javed, Kurose, Yohei, Canny, Benedict, Clarke, Iain J

“…Ghrelin is an endogenous ligand for the GH secretagogue/ghrelin receptor (GHS-R) and stimulates feeding behavior and GH levels in rodents and humans. A…”
Get full text

Chronic food-restriction alters the expression of somatostatin and growth hormone-releasing hormone in the ovariectomised ewe by Henry, BA, Rao, A, Tilbrook, AJ, Clarke, IJ

“…Changes in the secretion of GH induced by long-term alterations in nutritional status are thought to result from alterations in somatostatin (SRIF) and growth…”
Get full text

Colocalization of Kisspeptin and Gonadotropin-Releasing Hormone in the Ovine Brain by Pompolo, S, Pereira, A, Estrada, K. M, Clarke, I. J

“…Kisspeptin is a peptide that has been implicated in the regulation of GnRH cells in the brain. Immunohistochemical studies were undertaken to examine the…”
Get full text

Perinatal growth and plasma GH profiles in adolescent and adult sheep by Gatford, KL, Clarke, IJ, De Blasio, MJ, McMillen, IC, J, S Robinson, Owens, JA

“…Poor prenatal growth is associated with limited evidence of GH deficiency in adult humans, which may contribute to their increased risk of cardiovascular and…”
Get full text

The influence of sex and gonadectomy on the hypothalamo-pituitary-adrenal axis of the sheep by Canny, BJ, O'Farrell, KA, Clarke, IJ, Tilbrook, AJ

“…There is a sex difference in the hypothalamo-pituitary-adrenal (HPA) axis of many species, although there are sparse data on the sheep. In the present study we…”
Get full text

Localization of leptin receptor-like immunoreactivity in the corticotropes, somatotropes, and gonadotropes in the ovine anterior pituitary by Iqbal, J, Pompolo, S, Considine, R V, Clarke, I J

“…Leptin is a secreted product of the adipocytes that regulates a variety of functions. The presence of the leptin receptor (LR) has been demonstrated in the…”
Get full text

Tissue-specific regulation of gastrin-releasing peptide synthesis, storage and secretion by oestrogen and progesterone by Whitley, JC, Giraud, AS, Mahoney, AO, Clarke, IJ, Shulkes, A

“…In the ovine endometrium, dramatic increases in gastrin-releasing peptide (GRP) mRNA and immunoreactivity are observed during the luteal regression phase of…”
Get full text

Central administration of leptin to ovariectomized ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland: evidence for a dissociation of effects on appetite and neuroendocrine function by Henry, B A, Goding, J W, Alexander, W S, Tilbrook, A J, Canny, B J, Dunshea, F, Rao, A, Mansell, A, Clarke, I J

“…We have studied the effect of leptin on food intake and neuroendocrine function in ovariectomized ewes. Groups (n = 5) received intracerebroventricular…”
Get full text

Progesterone and testosterone in combination act in the hypothalamus of castrated rams to regulate the secretion of LH by Turner, AI, Tilbrook, AJ, Clarke, IJ, Scott, CJ

“…We tested the hypotheses that progesterone enhances the negative feedback actions of testosterone in rams and that this occurs through actions at the…”
Get full text

Changes in the suppressive effects of recombinant inhibin A on FSH secretion in ram lambs during sexual maturation: evidence for alterations in the clearance rate of inhibin by Tilbrook, AJ, de Kretser, DM, Clarke, IJ

“…We have investigated the effectiveness of human recombinant inhibin A (hr-inhibin A) to suppress the secretion of follicle-stimulating hormone (FSH) in ram…”
Get full text

Negative Feedback Regulation of the Secretion and Actions of Gonadotropin-Releasing Hormone in Males by Tilbrook, A. J, Clarke, I. J

“…This minireview considers the state of knowledge regarding the interactions of testicular hormones to regulate the secretion and actions of GnRH in males, with…”
Get full text

Seasonal changes in the negative feedback regulation of the secretion of the gonadotrophins by testosterone and inhibin in rams by Tilbrook, AJ, de Kretser, DM, Clarke, IJ

“…Three experiments were conducted with castrated Romney Marsh rams (wethers) to investigate the ability of testosterone and inhibin to suppress the secretion of…”
Get full text