Search Results - "Clarke, G"

Protein methylation at the surface and buried deep: thinking outside the histone box by Clarke, Steven G.

“…Methylated lysine and arginine residues in histones represent a crucial part of the histone code, and recognition of these methylated residues by protein…”
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Kynurenine pathway metabolism and the microbiota-gut-brain axis by Kennedy, P.J., Cryan, J.F., Dinan, T.G., Clarke, G.

“…It has become increasingly clear that the gut microbiota influences not only gastrointestinal physiology but also central nervous system (CNS) function by…”
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Serotonin, tryptophan metabolism and the brain-gut-microbiome axis by O’Mahony, S.M., Clarke, G., Borre, Y.E., Dinan, T.G., Cryan, J.F.

“…•Serotonin is a key neurotransmitter in the brain-gut axis.•The gut microbiome is also critical to the normal functioning of the brain-gut axis.•Behaviour…”
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Microbiota is essential for social development in the mouse by Desbonnet, L, Clarke, G, Shanahan, F, Dinan, T G, Cryan, J F

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The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner by Clarke, G, Grenham, S, Scully, P, Fitzgerald, P, Moloney, R D, Shanahan, F, Dinan, T G, Cryan, J F

“…Bacterial colonisation of the intestine has a major role in the post-natal development and maturation of the immune and endocrine systems. These processes are…”
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Regulation of prefrontal cortex myelination by the microbiota by Hoban, A E, Stilling, R M, Ryan, F J, Shanahan, F, Dinan, T G, Claesson, M J, Clarke, G, Cryan, J F

“…The prefrontal cortex (PFC) is a key region implicated in a range of neuropsychiatric disorders such as depression, schizophrenia and autism. In parallel, the…”
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Contribution of Alaskan glaciers to sea-level rise derived from satellite imagery by Berthier, E, Schiefer, E, Clarke, G. K. C, Menounos, B, Rémy, F

“…Over the past 50 years, retreating glaciers and ice caps contributed 0.5 mm yr−1 to sea-level rise, and one third of this contribution is believed to come from…”
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The microbiome regulates amygdala-dependent fear recall by Hoban, A E, Stilling, R M, Moloney, G, Shanahan, F, Dinan, T G, Clarke, G, Cryan, J F

“…The amygdala is a key brain region that is critically involved in the processing and expression of anxiety and fear-related signals. In parallel, a growing…”
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The ribosome: A hot spot for the identification of new types of protein methyltransferases by Clarke, Steven G.

“…Cellular physiology depends on the alteration of protein structures by covalent modification reactions. Using a combination of bioinformatic, genetic,…”
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Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression by Desbonnet, L, Garrett, L, Clarke, G, Kiely, B, Cryan, J.F, Dinan, T.G

“…Abstract The concept that intestinal microbial composition not only affects the health of the gut, but also influences centrally-mediated systems involved in…”
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Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers by Allen, A P, Hutch, W, Borre, Y E, Kennedy, P J, Temko, A, Boylan, G, Murphy, E, Cryan, J F, Dinan, T G, Clarke, G

“…The emerging concept of psychobiotics—live microorganisms with a potential mental health benefit—represents a novel approach for the management of…”
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Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle? by O’Mahony, S.M, Clarke, G, Dinan, T.G, Cryan, J.F

“…Highlights • Vulnerable neurodevelopmental windows exist during the life span. • Adverse events during these times include altered gut microbiota. • Increased…”
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Cordilleran Ice Sheet mass loss preceded climate reversals near the Pleistocene Termination by Menounos, B., Goehring, B. M., Osborn, G., Margold, M., Ward, B., Bond, J., Clarke, G. K. C., Clague, J. J., Lakeman, T., Koch, J., Caffee, M. W., Gosse, J., Stroeven, A. P., Seguinot, J., Heyman, J.

“…The Cordilleran Ice Sheet (CIS) once covered an area comparable to that of Greenland. Previous geologic evidence and numerical models indicate that the ice…”
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Calculated phase equilibria for MORB compositions: a reappraisal of the metamorphic evolution of lawsonite eclogite by WEI, C. J., CLARKE, G. L.

“…Pseudosections calculated with thermocalc predict that lawsonite‐bearing assemblages, including lawsonite eclogite, will be common for subducted oceanic crust…”
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Modeling the effect of glacier recession on streamflow response using a coupled glacio-hydrological model by Naz, B. S, Frans, C. D, Clarke, G. K. C, Burns, P, Lettenmaier, D. P

“…We describe an integrated spatially distributed hydrologic and glacier dynamic model, and use it to investigate the effect of glacier recession on streamflow…”
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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR) by García-Martínez, Juan M, Moran, Jennifer, Clarke, Rosemary G, Gray, Alex, Cosulich, Sabina C, Chresta, Christine M, Alessi, Dario R

“…mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein…”
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Review article: probiotics for the treatment of irritable bowel syndrome - focus on lactic acid bacteria by Clarke, G., Cryan, J. F., Dinan, T. G., Quigley, E. M.

“…Summary Background Irritable bowel syndrome (IBS) is a poorly understood, yet highly prevalent functional gastrointestinal disorder (FGID). The withdrawal, due…”
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The microbiota-gut-brain axis as a key regulator of neural function and the stress response: Implications for human and animal health by Wiley, N C, Dinan, T G, Ross, R P, Stanton, C, Clarke, G, Cryan, J F

“…The brain-gut-microbiota axis comprises an extensive communication network between the brain, the gut, and the microbiota residing there. Development of a…”
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A sustained hypothalamic-pituitary-adrenal axis response to acute psychosocial stress in irritable bowel syndrome by Kennedy, P J, Cryan, J F, Quigley, E M M, Dinan, T G, Clarke, G

“…Despite stress being considered a key factor in the pathophysiology of the functional gastrointestinal (GI) disorder irritable bowel syndrome (IBS), there is a…”
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P‐TS‐52 | Laboratory Quantification of Fetal Maternal Hemorrhage: Practice Survey and Scoping Review by Hajjaj, O., Clarke, G., Callum, J., Shehata, N., Lieberman, L.

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