Search Results - "Clarke, Deborah L"

The epithelium in idiopathic pulmonary fibrosis: breaking the barrier by Camelo, Ana, Dunmore, Rebecca, Sleeman, Matthew A, Clarke, Deborah L

“…Idiopathic pulmonary fibrosis is a progressive disease of unknown etiology characterized by a dysregulated wound healing response that leads to fatal…”
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Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium by Slater, Louise, Bartlett, Nathan W, Haas, Jennifer J, Zhu, Jie, Message, Simon D, Walton, Ross P, Sykes, Annemarie, Dahdaleh, Samer, Clarke, Deborah L, Belvisi, Maria G, Kon, Onn M, Fujita, Takashi, Jeffery, Peter K, Johnston, Sebastian L, Edwards, Michael R

“…The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. We investigated the…”
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Long Non-coding RNAs Are Central Regulators of the IL-1β-Induced Inflammatory Response in Normal and Idiopathic Pulmonary Lung Fibroblasts by Hadjicharalambous, Marina R, Roux, Benoit T, Feghali-Bostwick, Carol A, Murray, Lynne A, Clarke, Deborah L, Lindsay, Mark A

“…There is accumulating evidence to indicate that long non-coding RNAs (lncRNAs) are important regulators of the inflammatory response. In this report, we have…”
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Long intergenic non-coding RNAs regulate human lung fibroblast function: Implications for idiopathic pulmonary fibrosis by Hadjicharalambous, Marina R., Roux, Benoit T., Csomor, Eszter, Feghali-Bostwick, Carol A., Murray, Lynne A., Clarke, Deborah L., Lindsay, Mark A.

“…Phenotypic changes in lung fibroblasts are believed to contribute to the development of Idiopathic Pulmonary Fibrosis (IPF), a progressive and fatal lung…”
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Matrix regulation of idiopathic pulmonary fibrosis: the role of enzymes by Clarke, Deborah L, Carruthers, Alan M, Mustelin, Tomas, Murray, Lynne A

“…Repairing damaged tissues is an essential homeostatic mechanism that enables clearance of dead or damaged cells after injury, and the maintenance of tissue…”
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Development of a mouse model mimicking key aspects of a viral asthma exacerbation by Clarke, Deborah L, Davis, Nicola H E, Majithiya, Jayesh B, Piper, Sian C, Lewis, Arthur, Sleeman, Matthew A, Corkill, Dominic J, May, Richard D

“…Viral respiratory tract infections are known triggers of asthma exacerbations in both adults and children. The current standard of care, inhaled CS…”
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Defining critical roles for NF‐κB p65 and type I interferon in innate immunity to rhinovirus by Bartlett, Nathan W., Slater, Louise, Glanville, Nicholas, Haas, Jennifer J., Caramori, Gaetano, Casolari, Paolo, Clarke, Deborah L., Message, Simon D., Aniscenko, Julia, Kebadze, Tatiana, Zhu, Jie, Mallia, Patrick, Mizgerd, Joseph P., Belvisi, Maria, Papi, Alberto, Kotenko, Sergei V., Johnston, Sebastian L., Edwards, Michael R.

“…The importance of NF‐κB activation and deficient anti‐viral interferon induction in the pathogenesis of rhinovirus‐induced asthma exacerbations is poorly…”
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Patient Reported Experiences and Delays During the Diagnostic Pathway for Pulmonary Fibrosis: A Multinational European Survey by van der Sar, Iris G., Jones, Steve, Clarke, Deborah L., Bonella, Francesco, Fourrier, Jean Michel, Lewandowska, Katarzyna, Bermudo, Guadalupe, Simidchiev, Alexander, Strambu, Irina R., Wijsenbeek, Marlies S., Parfrey, Helen

“…Introduction: Pulmonary fibrosis includes a spectrum of diseases and is incurable. There is a variation in disease course, but it is often progressive leading…”
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TNFα and IFNγ Synergistically Enhance Transcriptional Activation of CXCL10 in Human Airway Smooth Muscle Cells via STAT-1, NF-κB, and the Transcriptional Coactivator CREB-binding Protein by Clarke, Deborah L., Clifford, Rachel L., Jindarat, Sarawut, Proud, David, Pang, Linhua, Belvisi, Maria, Knox, Alan J.

“…Asthmatic airway smooth muscle (ASM) expresses interferon-γ-inducible protein-10 (CXCL10), a chemokine known to mediate mast cell migration into ASM bundles…”
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TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein by Clarke, Deborah L, Clifford, Rachel L, Jindarat, Sarawut, Proud, David, Pang, Linhua, Belvisi, Maria, Knox, Alan J

“…Asthmatic airway smooth muscle (ASM) expresses interferon-γ-inducible protein-10 (CXCL10), a chemokine known to mediate mast cell migration into ASM bundles…”
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Is personalised medicine the key to heterogeneity in idiopathic pulmonary fibrosis? by Clarke, Deborah L, Murray, Lynne A, Crestani, Bruno, Sleeman, Matthew A

“…Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneumonia of unknown cause, characterised by progressive worsening in lung function and…”
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Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor by Clarke, Deborah L, Belvisi, Maria G, Smith, Susan J, Hardaker, Elizabeth, Yacoub, Magdi H, Meja, Koremu K, Newton, Robert, Slater, Donna M, Giembycz, Mark A

“…The prostanoid receptors on human airway smooth muscle cells (HASMC) that augment the release by IL-1beta of granulocyte colony-stimulating factor (G-CSF) have…”
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EP4 receptor as a new target for bronchodilator therapy by Buckley, James, Birrell, Mark A, Maher, Sarah A, Nials, Anthony T, Clarke, Deborah L, Belvisi, Maria G

“…Asthma and chronic obstructive pulmonary disease are airway inflammatory diseases characterised by airflow obstruction. Currently approved bronchodilators such…”
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E-ring 8-isoprostanes are agonists at EP2- and EP4-prostanoid receptors on human airway smooth muscle cells and regulate the release of colony-stimulating factors by activating cAMP-dependent protein kinase by Clarke, Deborah L, Belvisi, Maria G, Hardaker, Elizabeth, Newton, Robert, Giembycz, Mark A

“…8-Isoprostanes are bioactive lipid mediators formed via the nonenzymatic peroxidation of arachidonic acid by free radicals and reactive oxygen species…”
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Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kB and AP-1 by Sutcliffe, Amy M, Clarke, Deborah L, Bradbury, Dawn A, Corbett, Lisa M, Patel, Jamie A, Knox, Alan J

“…Background and purpose: Endothelin-1 (ET-1) is implicated in airway inflammation in asthma, but the mechanisms of its effects are poorly understood. We studied…”
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Transcriptional regulation of monocyte chemotactic protein‐1 release by endothelin‐1 in human airway smooth muscle cells involves NF‐κB and AP‐1 by Sutcliffe, Amy M, Clarke, Deborah L, Bradbury, Dawn A, Corbett, Lisa M, Patel, Jamie A, Knox, Alan J

“…Background and purpose:  Endothelin‐1 (ET‐1) is implicated in airway inflammation in asthma, but the mechanisms of its effects are poorly understood. We…”
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Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE 2 inhibits the release of GM‐CSF by Clarke, Deborah L, Belvisi, Maria G, Catley, Matthew C, Yacoub, Magdi H, Newton, Robert, Giembycz, Mark A

“…The prostanoid receptor(s) on human airways smooth muscle (HASM) cells that mediates the inhibitory effect of PGE 2 on interleukin (IL)‐1 β ‐induced…”
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Are mast cells instrumental for fibrotic diseases? by Overed-Sayer, Catherine, Rapley, Laura, Mustelin, Tomas, Clarke, Deborah L

“…Idiopathic pulmonary fibrosis (IPF) is a fatal lung disorder of unknown etiology characterized by accumulation of lung fibroblasts and extracellular matrix…”
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Lipid metabolites as regulators of airway smooth muscle function by Clarke, Deborah L, Dakshinamurti, Shyamala, Larsson, Anna-Karin, Ward, Jane E, Yamasaki, Akira

“…Abstract Compelling evidence identifies airway smooth muscle (ASM) not only as a target but also a cellular source for a diverse range of mediators underlying…”
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Liver X Receptor Agonists Increase Airway Reactivity in a Model of Asthma via Increasing Airway Smooth Muscle Growth by Birrell, Mark A, De Alba, Jorge, Catley, Matthew C, Hardaker, Elizabeth, Wong, Sissie, Collins, Michael, Clarke, Deborah L, Farrow, Stuart N, Willson, Timothy M, Collins, Jon L, Belvisi, Maria G

“…The liver X receptors (LXRalpha/beta) are orphan nuclear receptors that are expressed in a large number of cell types and have been shown to have…”
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