Search Results - "Clarke, David C"

ADP is the dominant controller of AMP-activated protein kinase activity dynamics in skeletal muscle during exercise by Coccimiglio, Ian F, Clarke, David C

“…Exercise training elicits profound metabolic adaptations in skeletal muscle cells. A key molecule in coordinating these adaptations is AMP-activated protein…”
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Assessing recent warming using instrumentally homogeneous sea surface temperature records by Hausfather, Zeke, Cowtan, Kevin, Clarke, David C, Jacobs, Peter, Richardson, Mark, Rohde, Robert

“…Sea surface temperature (SST) records are subject to potential biases due to changing instrumentation and measurement practices. Significant differences exist…”
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Kinetic modeling of leucine-mediated signaling and protein metabolism in human skeletal muscle by McColl, Taylor J., Clarke, David C.

“…Skeletal muscle protein levels are governed by the relative rates of muscle protein synthesis (MPS) and breakdown (MPB). The mechanisms controlling these rates…”
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The Benefits of Continuous Local Regression for Quantifying Global Warming by Clarke, David C., Richardson, Mark

“…Change in global mean surface temperature (ΔGMST), based on a blend of land air and ocean water temperatures, is a widely cited climate change indicator that…”
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Rationale and Resources for Teaching the Mathematical Modeling of Athletic Training and Performance by Clarke, David C, Skiba, Philip F

“…A number of professions rely on exercise prescription to improve health or athletic performance, including coaching, fitness/personal training, rehabilitation,…”
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Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli by Morris, Melody K, Saez-Rodriguez, Julio, Clarke, David C, Sorger, Peter K, Lauffenburger, Douglas A

“…Predictive understanding of cell signaling network operation based on general prior knowledge but consistent with empirical data in a specific environmental…”
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Ketogenic diet for mitochondrial disease: potential role in treating the Multiple Symmetric Lipomatosis phenotype associated with the common MT-TK genetic mutation by Mattman, Andre, Nadeau, Elizabeth, Mezei, Michelle M, Cresswell, Mark, Zhao, Sida, Bosdet, Taryn, Sin, Don D, Guenette, Jordan A, Dupuis, Isabelle, Allin, Emily, Clarke, David C

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Linking proteomic and transcriptional data through the interactome and epigenome reveals a map of oncogene-induced signaling by Huang, Shao-shan Carol, Clarke, David C, Gosline, Sara J C, Labadorf, Adam, Chouinard, Candace R, Gordon, William, Lauffenburger, Douglas A, Fraenkel, Ernest

“…Cellular signal transduction generally involves cascades of post-translational protein modifications that rapidly catalyze changes in protein-DNA interactions…”
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The effects of endurance training on muscle oxygen desaturation during incremental exercise tests: a systematic review and meta-analysis by Yogev, Assaf, Arnold, Jem I., Nelson, Hannah, Rosenblat, Michael A., Clarke, David C., Guenette, Jordan A., Sporer, Ben C., Koehle, Michael S.

“…Objective Minimum muscle oxygen saturation (SmO 2 min) measured via near-infrared spectroscopy (NIRS) is a common measure during incremental exercise testing…”
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Comparing the reliability of muscle oxygen saturation with common performance and physiological markers across cycling exercise intensity by Yogev, Assaf, Arnold, Jem, Nelson, Hannah, Clarke, David C., Guenette, Jordan A., Sporer, Ben C., Koehle, Michael S.

“…Introduction Wearable near-infrared spectroscopy (NIRS) measurements of muscle oxygen saturation (SmO 2 ) demonstrated good test–retest reliability at rest. We…”
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Augmented-reality swim goggles accurately and reliably measure swim performance metrics in recreational swimmers by Eisenhardt, Dan, Kits, Aidan, Madeleine, Pascal, Samani, Afshin, Clarke, David C, Kristiansen, Mathias

“…Swimmers commonly access performance metrics such as lap splits, distance, and pacing information between work bouts while they rest. Recently, a new category…”
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The effect of severe intensity bouts on muscle oxygen saturation responses in trained cyclists by Yogev, Assaf, Arnold, Jem, Nelson, Hannah, Clarke, David C, Guenette, Jordan A, Sporer, Ben C, Koehle, Michael S

“…Near-infrared spectroscopy (NIRS) quantifies muscle oxygenation (SmO ) during exercise. Muscle oxygenation response to self-paced, severe-intensity cycling…”
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The Critical Power Model as a Potential Tool for Anti-doping by Puchowicz, Michael J, Mizelman, Eliran, Yogev, Assaf, Koehle, Michael S, Townsend, Nathan E, Clarke, David C

“…Existing doping detection strategies rely on direct and indirect biochemical measurement methods focused on detecting banned substances, their metabolites, or…”
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Transforming Growth Factor β Depletion Is the Primary Determinant of Smad Signaling Kinetics by Clarke, David C., Brown, Meredith L., Erickson, Richard A., Shi, Yigong, Liu, Xuedong

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Multi-pathway network analysis of mammalian epithelial cell responses in inflammatory environments by Clarke, David C, Lauffenburger, Douglas A

“…Inflammation is a key physiological response to infection and injury and, although usually beneficial, it can also be damaging to the host. The liver is a…”
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The W' Balance Model: Mathematical and Methodological Considerations by Skiba, Philip Friere, Clarke, David C

“…Since its publication in 2012, the W' balance model has become an important tool in the scientific armamentarium for understanding and predicting human…”
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Progress in physiologically based pharmacokinetic-pharmacodynamic models of amino acids in humans by McColl, Taylor J, Clarke, David C

“…Amino acids are critical to health, serving both as constituents of proteins and in signaling and metabolism. Amino acids are consumed as nutrients,…”
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A hydraulic model outperforms work-balance models for predicting recovery kinetics from intermittent exercise by Weigend, Fabian C., Clarke, David C., Obst, Oliver, Siegler, Jason

“…Data Science advances in sports commonly involve “big data”, i.e., large sport-related data sets. However, such big data sets are not always available,…”
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Development and field validation of an omni-domain power-duration model by Puchowicz, Michael J., Baker, Jonathan, Clarke, David C.

“…Purpose: To validate and compare a novel model based on the critical power (CP) concept that describes the entire domain of maximal mean power (MMP) data from…”
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Intramuscular determinants of the ability to recover work capacity above critical power by Skiba, Philip Friere, Fulford, Jonathan, Clarke, David C., Vanhatalo, Anni, Jones, Andrew M.

“…Purpose The primary purpose of this investigation was to compare the recovery of the W′ to the recovery of intramuscular substrates and metabolites using 31 P-…”
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