Search Results - "Clarke, B. R."

Isolation and characterization of human mammary stem cells by Clarke, R. B.

“…  Since stem cells are present throughout the lifetime of an organism, it is thought that they may accumulate mutations, eventually leading to cancer. In the…”
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Estrogen Receptor-Positive Proliferating Cells in the Normal and Precancerous Breast by Shoker, Balvinder S., Jarvis, Christine, Clarke, Robert B., Anderson, Elizabeth, Hewlett, Joanne, Davies, Michael P.A., Sibson, D. Ross, Sloane, John P.

“…Recently it has been shown that epithelial cell expression of the estrogen receptor (ER) and that of the proliferation-associated marker Ki-67 are almost…”
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Dissociation between steroid receptor expression and cell proliferation in the human breast by CLARKE, R. B, HOWELL, A, POTTEN, C. S, ANDERSON, E

“…We have shown previously that estradiol stimulates cell proliferation and progesterone receptor (PgR) synthesis in luminal epithelial cells of the normal human…”
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Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue by Wilson, C L, Sims, A H, Howell, A, Miller, C J, Clarke, R B

“…Oestrogen (E) is essential for normal and cancer development in the breast, while anti-oestrogens have been shown to reduce the risk of the disease. However,…”
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Host range of a plant pathogenic fungus determined by a saponin detoxifying enzyme by Bowyer, P. (John Innes Centre, Norwich, UK.), Clarke, B.R, Lunness, P, Daniels, M.J, Osbourn, A.E

“…Antifungal saponins occur in many plant species and may provide a preformed chemical barrier to attack by phytopathogenic fungi. Some fungal pathogens can…”
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Tumour-promoting activity of altered WWP1 expression in breast cancer and its utility as a prognostic indicator by Nguyen Huu, NS, Ryder, WDJ, Zeps, N, Flasza, M, Chiu, M, Hanby, AM, Poulsom, R, Clarke, RB, Baron, M

“…WWP1 is a ubiquitin ligase, associated with the post-translational regulation of several tumour-promoting and tumour suppressor proteins. Here we show that…”
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Effects of oestrogens and anti-oestrogens on normal breast tissue from women bearing BRCA1 and BRCA2 mutations by BRAMLEY, M, CLARKE, R. B, HOWELL, A, EVANS, D. G. R, ARMER, T, BAILDAM, A. D, ANDERSON, E

“…There is considerable interest in whether anti-oestrogens can be used to prevent breast cancer in women bearing mutations in the BRCA1 and BRCA2 genes. The…”
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Human breast cell proliferation and its relationship to steroid receptor expression by Clarke, RB

“…The steroidal regulation of proliferation and differentiation in the rodent mammary gland is well described, but how ovarian hormones regulate these processes…”
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Type I insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone by CLARKE, R. B, HOWELL, A, ANDERSON, E

“…The epithelial proliferation of normal human breast tissue xenografts implanted into athymic nude mice is significantly increased from basal levels by…”
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Abnormal regulation of the oestrogen receptor in benign breast lesions by Shoker, B S, Jarvis, C, Clarke, R B, Anderson, E, Munro, C, Davies, M P A, Sibson, D R, Sloane, J P

“…Background—In normal breast tissue the oestrogen receptor (ER) and the proliferation associated antigen Ki67 are negatively associated, indicating that ER+…”
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Cyclin-dependent kinase inhibitors and basement membrane interact to regulate breast epithelial cell differentiation and acinar morphogenesis by Coppock, H. A., Gilham, D. E., Howell, A., Clarke, R. B.

“…  Objective: The cyclin‐dependent kinase inhibitors (CDKIs), p21CIP1 and p27KIP1 regulate growth and differentiation in diverse tissue types. We aimed to…”
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Estrogen sensitivity of normal human breast tissue in vivo and implanted into athymic nude mice : Analysis of the relationship between estrogen-induced proliferation and progesterone receptor expression by CLARKE, R. B, HOWELL, A, ANDERSON, E

“…High serum concentrations of estradiol (E2) equivalent to those observed in the luteal phase of the menstrual cycle stimulate both epithelial cell…”
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Effect of tamoxifen on Ki67 labelling index in human breast tumours and its relationship to oestrogen and progesterone receptor status by CLARKE, R. B, LAIDLAW, I. J, JONES, L. J, HOWELL, A, ANDERSON, E

“…This study aimed to investigate the effect of tamoxifen on breast tumour levels of oestrogen and progesterone receptor (ER and PR) and proliferation as defined…”
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Molecular cloning of the rfb region of Klebsiella pneumoniae serotype O1:K20: the rfb gene cluster is responsible for synthesis of the D-galactan I O polysaccharide by CLARKE, B. R, WHITFIELD, C

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A putative human breast stem cell population is enriched for steroid receptor-positive cells by Clarke, Robert B., Spence, Katherine, Anderson, Elizabeth, Howell, Anthony, Okano, Hideyuki, Potten, Christopher S.

“…Breast epithelial stem cells are thought to be the primary targets in the etiology of breast cancer. Since breast cancers mostly express estrogen and…”
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Role of Rfe and RfbF in the initiation of biosynthesis of D-galactan I, the lipopolysaccharide O antigen from Klebsiella pneumoniae serotype O1 by Clarke, B R, Bronner, D, Keenleyside, W J, Severn, W B, Richards, J C, Whitfield, C

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Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity by WILSON, G. R, CRAMER, A, WELMAN, A, KNOX, F, SWINDELL, R, KAWAKATSU, H, CLARKE, Rb, DIVE, C., BUNDRED, N. J

“…Overexpression and/or activity of c-Src non-receptor tyrosine kinase is associated with progression of several human epithelial cancers including breast…”
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P27(KIP1) expression indicates that steroid receptor-positive cells are a non-proliferating, differentiated subpopulation of the normal human breast epithelium by Clarke, R B, Howell, A, Potten, C S, Anderson, E

“…To test the hypothesis that steroid receptor-expressing cells are derived from the proliferative population, we examined expression of the p27(KIP1) inhibitor…”
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Expression of two structurally distinct D-galactan O antigens in the lipopolysaccharide of Klebsiella pneumoniae serotype O1 by WHITFIELD, C, RICHARDS, J. C, PERRY, M. B, CLARKE, B. R, MACLEAN, L. L

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Tumour-promoting activity of altered WWPI expression in breast cancer and its utility as a prognostic indicator by NGUYEN HUU, N. S, RYDER, W. D. J, ZEPS, N, FLASZA, M, CHIU, M, HANBY, A. M, POULSOM, R, CLARKE, R. B, BARON, M

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