Search Results - "Clark, William M"

Large-scale synthesis of SB-462795, a cathepsin K inhibitor: the RCM-based approaches by Wang, Huan, Matsuhashi, Hayao, Doan, Brian D., Goodman, Steven N., Ouyang, Xi, Clark, William M.

“…Two stereoselective syntheses of SB-462795, a highly potent cathepsin K inhibitor, are described. Both routes feature a C5–C6 disconnection by ring closing…”
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A Scalable Oxidation for the Final Stage of Synthesis of Cathepsin K Inhibitor SB-462795 by Goodman, Steven N, Dai, Qunying, Wang, Jun, Clark, William M

“…In developing the manufacturing route for the cathepsin K inhibitor SB-462795, the oxidation of a secondary alcohol for the final chemical stage is described…”
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Waking Up With Cloudy Vision by Khine, Kay T, Clark, William M, Harbour, J William

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A Catalytic Enantioselective Synthesis of the Endothelin Receptor Antagonists SB-209670 and SB-217242. A Base-Catalyzed Stereospecific Formal 1,3-Hydrogen Transfer of a Chiral 3-Arylindenol by Clark, William M, Tickner-Eldridge, Ann M, Huang, G. Kris, Pridgen, Lendon N, Olsen, Mark A, Mills, Robert J, Lantos, Ivan, Baine, Neil H

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Biodiesel transesterification kinetics monitored by pH measurement by Clark, William M., Medeiros, Nicholas J., Boyd, Donal J., Snell, Jared R.

“…Quantification of a pH change that was observed over the course of the transesterification reaction that converts vegetable oil to biodiesel may provide a…”
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Development of a Robust Ring-Closing Metathesis Reaction in the Synthesis of SB-462795, a Cathepsin K Inhibitor by Wang, Huan, Goodman, Steven N, Dai, Qunying, Stockdale, Gregory W, Clark, William M

“…The development of a robust and high-yielding ring-closing metathesis (RCM) reaction and its demonstration on multikilogram scale are described. A detailed…”
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Numerical Analysis of Two-Phase Electrophoresis by Clark, William M., Lindblad, Mark A.

“…Numerical modeling results for electrophoresis in aqueous two-phase systems are shown to agree with experimental results in both batch and flow devices. A…”
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Tremorgenic Indole Alkaloids. 9. Asymmetric construction of an Advanced F-G-H-ring Lactone precursor for the Synthesis of Penitrem D by Smith, Amos B, Nolen, Ernest G, Shirai, Ryuichi, Blase, Frances R, Ohta, Mitsuaki, Chida, Noritaka, Hartz, Richard A, Fitch, Duke M, Clark, William M, Sprengeler, Paul A

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Heat Transfer in Glass, Aluminum, and Plastic Beverage Bottles by Clark, William M, Shevlin, Ryan C, Soffen, Tanya S

“…This paper addresses a controversy regarding the effect of bottle material on the thermal performance of beverage bottles. Experiments and calculations that…”
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The electrochemical preparation and kinetic and product studies of acylated quinol and quinol ether imines. In search of the hydrolysis products of the ultimate carcinogen of N-acetyl-2-aminofluorene by Novak, Michael, Helmick, John S, Oberlies, Nicholas, Rangappa, Kanchugarakoppal S, Clark, William M, Swenton, John S

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The chemistry of acylated quinone imine ketals. Nucleophilic and organolithium addition reactions by Swenton, John S, Bonke, Brian R, Clark, William M, Chen, Chung Pin, Martin, Kevin V

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A Practical and Efficient Large-Scale Preparation of (4R,5S)-N-Propenoyl-1,5- dimethyl-4-phenylimidazolidin-2-one. A Simple Procedure for the Preparation of N-Acylimidazolidin-2-ones and N-Acylbornane 2,10-Sultams by Clark, William M, Bender, Corey

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A Highly Enantioselective Conjugate Reduction of 3-Arylinden-1-ones Using Bakers' Yeast for the Preparation of (S)-3-Arylindan-1-ones by Clark, William M, Kassick, Andrew J, Plotkin, Michael A, Eldridge, Ann M, Lantos, Ivan

“…The bakers' yeast reduction of 3-(1,3-benzodioxol-5-yl)-6-propoxy-1H-inden-1-one 4 has been shown to give…”
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A Project-based Spiral Curriculum for Introductory Courses in ChE: Part 3. Evaluation by DiBiasio, David, Comparini, Lisa, Dixon, Anthony G, Clark, William M

“…Presents the third part of a series on the development and implementation of project-based spiral curriculum in chemical engineering. Focuses on the details of…”
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A Project-based Spiral Curriculum for Introductory Courses in ChE: Part 2. Implementation by Dixon, Anthony G, Clark, William M, DiBiasio, David

“…Reports the development, delivery, and assessment of a project-based spiral curriculum for the first sequence chemical engineering courses. Technical…”
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Abstract TP246: Emergency Medical Services Survey of a Low-cost, Ambulance-based System for Mobile Neurological Assessment: The iTREAT Study by Clark, William M, Chiota-McCollum, Nicole A, Cote, Jack, Schneider, Brett J, Pitchford, Haydon, Gunnell, Brian S, Lindbeck, George M, Perina, Debra G, O’Connor, Robert E, Chapman Smith, Sherita N, Solenski, Nina J, Worrall, Bradford B, Southerland, Andrew M

“…Abstract only Introduction: Modern advances in acute stroke care place an added emphasis on accurate prehospital diagnosis and triage. As part of the Improving…”
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β-Lactamase Recovery from E. coli Cell Lysate via Two-Phase Electrophoresis by Oehler, Ryan D., Clark, William M.

“…β‐Lactamase was recovered from Escherichia coli cell lysate by a novel cell debris removal method using two‐phase electrophoresis. The cells were harvested by…”
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Preparation of quinol N-acyl- and quinol ether imines via anodic oxidation of para-substituted anilide derivatives by Swenton, John S, Biggs, Timothy N, Clark, William M

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An Experiment to Illustrate the Hazards of Exothermic Reaction Scale-Up by Clark, William, Lei, Melinda, Kirichenko, Erika, Dickerson, Kellie, Prytko, Robert

“…Exothermic reactions can present safety hazards and there is a recognized need for reaction safety education at the undergraduate level. We present an…”
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A spectroscopic and computational study of an electrocyclized photo-degradation product of 6-(2-(5-chloro-2-(2,4-difluorobenyzloxy)phenyl)cyclopent-1-enyl)picolinic acid by Vogt, Frederick G., Wu, Lianming, Olsen, Mark A., Clark, William M.

“…An unusual electrocyclized photo-degradation product of an EP 1 antagonist drug candidate, 6-(2-(5-chloro-2-(2,4-difluorobenyzloxy) phenyl) cyclopent-1-enyl)…”
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