Search Results - "Clark, Vanessa J."

A Common Haplotype of the Glucokinase Gene Alters Fasting Glucose and Birth Weight: Association in Six Studies and Population-Genetics Analyses by Weedon, Michael N., Clark, Vanessa J., Qian, Yudong, Ben-Shlomo, Yoav, Timpson, Nicholas, Ebrahim, Shah, Lawlor, Debbie A., Pembrey, Marcus E., Ring, Susan, Wilkin, Terry J., Voss, Linda D., Jeffery, Alison N., Metcalf, Brad, Ferrucci, Luigi, Corsi, Anna Maria, Murray, Anna, Melzer, David, Knight, Bridget, Shields, Bev, Smith, George Davey, Hattersley, Andrew T., Di Rienzo, Anna, Frayling, Tim M.

“…Fasting glucose is associated with future risk of type 2 diabetes and ischemic heart disease and is tightly regulated despite considerable variation in…”
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Detecting BRCA2 Protein Truncation in Tissue Biopsies to Identify Breast Cancers That Arise in BRCA2 Gene Mutation Carriers by WATSON, Patrice, LIEBERMAN, Rita, SNYDER, Carrie, CLARK, Vanessa J, LYNCH, Henry T, HOLT, Jeffrey T

“…Mutations in the BRCA2 gene are dominantly inherited but cause cancers when the wild-type allele has loss of heterozygosity (LOH) within the cancer. Because…”
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Population genetic analysis of the uncoupling proteins supports a role for UCP3 in human cold resistance by Hancock, Angela M, Clark, Vanessa J, Qian, Yudong, Di Rienzo, Anna

“…Production of heat via nonshivering thermogenesis (NST) is critical for temperature homeostasis in mammals. Uncoupling protein UCP1 plays a central role in NST…”
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Haplotype structure and linkage disequilibrium in chemokine and chemokine receptor genes by Clark, Vanessa J, Dean, Michael

“…To dissect the haplotype structure of candidate genes for disease association studies, it is important to understand the nature of genetic variation at these…”
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Natural selection and functional genetic variation in the p53 pathway by SUCHESTON, Lara, WITONSKY, David B, HASTINGS, Darcie, YILDIZ, Ozlem, CLARK, Vanessa J, DI RIENZO, Anna, ONEL, Kenan

“…The allele frequencies of two functional single-nucleotide polymorphisms (SNPs) in the p53 pathway, the MDM2 SNP309 and TP53 Arg72Pro, vary dramatically among…”
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Haplotype structure and phylogenetic shadowing of a hypervariable region in the CAPN10 gene by CLARK, Vanessa J, COX, Nancy J, HAMMOND, Molly, HANIS, Craig L, DI RIENZO, Anna

“…It has been proposed that variation in calpain 10 (CAPN10) contributes to the risk of type 2 diabetes (T2D). A previous survey of CAPN10 in ethnically diverse…”
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Characterisation of SNP haplotype structure in chemokine and chemokine receptor genes using CEPH pedigrees and statistical estimation by Clark, Vanessa J, Dean, Michael

“…Chemokine signals and their cell-surface receptors are important modulators of HIV-1 disease and cancer. To aid future case/control association studies, aim to…”
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Combining Sperm Typing and Linkage Disequilibrium Analyses Reveals Differences in Selective Pressures or Recombination Rates Across Human Populations by Clark, Vanessa J, Ptak, Susan E, Tiemann, Irene, Qian, Yudong, Coop, Graham, Stone, Anne C, Przeworski, Molly, Arnheim, Norman, Rienzo, Anna Di

“…A previous polymorphism survey of the type 2 diabetes gene CAPN10 identified a segment showing an excess of polymorphism levels in all population samples,…”
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The 9-bp Deletion between the Mitochondrial Lysine tRNA and COII Genes in Tribal Populations of India by CLARK, VANESSA J., SIVENDREN, SHANTHI, SAHA, NILMANI, BENTLEY, GILLIAN R., AUNGER, ROBERT, SIRAJUDDIN, S.M., STONEKING, MARK

“…A 9-base-pair (bp) deletion located between the lysine tRNA (MTTK) and COII (MTCOX*2) genes in the human mitochondrial genome is a valuable marker for tracing…”
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Statistical estimation and pedigree analysis ofCCR2-CCR5 haplotypes by Clark, Vanessa J., Metheny, Noah, Dean, Michael, Peterson, Raymond J.

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Statistical estimation and pedigree analysis of CCR2-CCR5 haplotypes by CLARK, Vanessa J, METHENY, Noah, DEAN, Michael, PETERSON, Raymond J

“…As more SNP marker data becomes available, researchers have used haplotypes of markers, rather than individual polymorphisms, for association analysis of…”
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Haplotype analysis of chemokine and chemokine receptor polymorphisms by Clark, Vanessa J

“…Motivated by the wealth of functional evidence that implicates chemokine signals in tumor development and metastasis, the ultimate goal of this study was to…”
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Haplotype analysis of chemokine and chemokine receptor polymorphisms by Clark, Vanessa J

“…Motivated by the wealth of functional evidence that implicates chemokine signals in tumor development and metastasis, the ultimate goal of this study was to…”
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Enhancement of hippocampally-mediated learning and protein kinase C activity by oxiracetam in learning-impaired DBA/2 mice by Fordyce, Diana E., Clark, Vanessa J., Paylor, Richard, Wehner, Jeanne M.

“…The effects of oxiracetam on hippocampally-mediated learning performance and hippocampal protein kinase C (PKC) were examined in C57BL/6Ibg (C57) and DBA/2Ibg…”
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Quantitative trait locus analyses of sleep-times induced by sedative-hypnotics in LSXSS recombinant inbred strains of mice by Christensen, S C, Johnson, T E, Markel, P D, Clark, V J, Fulker, D W, Corley, R P, Collins, A C, Wehner, J M

“…The long-sleep (LS) and short-sleep (SS) selected lines of mice show highly significant differences in sleep-time for many sedative-hypnotic drugs, and the…”
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