Search Results - "Clark, Trent"
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HIF-2α-dependent induction of miR-29a restrains TH1 activity during T cell dependent colitis
Published in Nature communications (14-09-2024)“…Metabolic imbalance leading to inflammatory hypoxia and stabilization of hypoxia-inducible transcription factors (HIFs) is a hallmark of inflammatory bowel…”
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Journal Article -
2
CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…The microenvironment that surrounds pancreatic ductal adenocarcinoma (PDAC) is profoundly desmoplastic and immunosuppressive. Understanding triggers of…”
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Journal Article -
3
Abstract IA013: Preclinical testing of CD73 inhibitors for pancreatic cancer immunoprevention
Published in Cancer prevention research (Philadelphia, Pa.) (01-12-2022)“…Abstract Introduction: The all stages combined five-year survival rate for pancreatic adenocarcinoma (PDA) is 11%; however, the five-year survival rate for…”
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Journal Article -
4
HIF-2α-dependent induction of miR-29a restrains T H 1 activity during T cell dependent colitis
Published in Nature communications (14-09-2024)“…Metabolic imbalance leading to inflammatory hypoxia and stabilization of hypoxia-inducible transcription factors (HIFs) is a hallmark of inflammatory bowel…”
Get full text
Journal Article -
5
Abstract 719: Preclinical testing of CD73 inhibitors for pancreatic cancer immunoprevention
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Abstract Introduction: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a profoundly immunosuppressive microenvironment. Innovative therapeutic…”
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Journal Article