Search Results - "Clark, Shaunna L"

Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples by Aberg, Karolina A., Dean, Brian, Shabalin, Andrey A., Chan, Robin F., Han, Laura K. M., Zhao, Min, van Grootheest, Gerard, Xie, Lin Y., Milaneschi, Yuri, Clark, Shaunna L., Turecki, Gustavo, Penninx, Brenda W. J. H., van den Oord, Edwin J. C. G.

“…We present the first large-scale methylome-wide association studies (MWAS) for major depressive disorder (MDD) to identify sites of potential importance for…”
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A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects by McClay, Joseph L, Aberg, Karolina A, Clark, Shaunna L, Nerella, Srilaxmi, Kumar, Gaurav, Xie, Lin Y, Hudson, Alexandra D, Harada, Aki, Hultman, Christina M, Magnusson, Patrik K E, Sullivan, Patrick F, Van Den Oord, Edwin J C G

“…The central importance of epigenetics to the aging process is increasingly being recognized. Here we perform a methylome-wide association study (MWAS) of aging…”
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High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction by McClay, Joseph L, Shabalin, Andrey A, Dozmorov, Mikhail G, Adkins, Daniel E, Kumar, Gaurav, Nerella, Srilaxmi, Clark, Shaunna L, Bergen, Sarah E, Hultman, Christina M, Magnusson, Patrik K E, Sullivan, Patrick F, Aberg, Karolina A, van den Oord, Edwin J C G

“…Genetic influence on DNA methylation is potentially an important mechanism affecting individual differences in humans. We use next-generation sequencing to…”
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Enrichment methods provide a feasible approach to comprehensive and adequately powered investigations of the brain methylome by Chan, Robin F, Shabalin, Andrey A, Xie, Lin Y, Adkins, Daniel E, Zhao, Min, Turecki, Gustavo, Clark, Shaunna L, Aberg, Karolina A, van den Oord, Edwin J C G

“…Methylome-wide association studies are typically performed using microarray technologies that only assay a very small fraction of the CG methylome and entirely…”
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A Whole Methylome CpG-SNP Association Study of Psychosis in Blood and Brain Tissue by van den Oord, Edwin J C G, Clark, Shaunna L, Xie, Lin Ying, Shabalin, Andrey A, Dozmorov, Mikhail G, Kumar, Gaurav, Vladimirov, Vladimir I, Magnusson, Patrik K E, Aberg, Karolina A

“…Mutated CpG sites (CpG-SNPs) are potential hotspots for human diseases because in addition to the sequence variation they may show individual differences in…”
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Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder by Andrade-Brito, Diego E, Núñez-Ríos, Diana L, Martínez-Magaña, José Jaime, Nagamatsu, Sheila T, Rompala, Gregory, Zillich, Lea, Witt, Stephanie H, Clark, Shaunna L, Lattig, Maria C, Montalvo-Ortiz, Janitza L

“…Alcohol use disorder (AUD) is a complex condition associated with adverse health consequences that affect millions of individuals worldwide. Epigenetic…”
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Evaluation of Methyl-Binding Domain Based Enrichment Approaches Revisited by Aberg, Karolina A, Xie, Linying, Chan, Robin F, Zhao, Min, Pandey, Ashutosh K, Kumar, Gaurav, Clark, Shaunna L, van den Oord, Edwin J C G

“…Methyl-binding domain (MBD) enrichment followed by deep sequencing (MBD-seq), is a robust and cost efficient approach for methylome-wide association studies…”
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Patterns of Substance Use Across the First Year of College and Associated Risk Factors by Cho, Seung Bin, Llaneza, Danielle C, Adkins, Amy E, Cooke, Megan, Kendler, Kenneth S, Clark, Shaunna L, Dick, Danielle M

“…Starting college is a major life transition. This study aims to characterize patterns of substance use across a variety of substances across the first year of…”
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Sample Size Requirements for Structural Equation Models: An Evaluation of Power, Bias, and Solution Propriety by Wolf, Erika J., Harrington, Kelly M., Clark, Shaunna L., Miller, Mark W.

“…Determining sample size requirements for structural equation modeling (SEM) is a challenge often faced by investigators, peer reviewers, and grant writers…”
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Epigenetic Aging in Major Depressive Disorder by Han, Laura K.M, Aghajani, Moji, Clark, Shaunna L, Chan, Robin F, Hattab, Mohammad W, Shabalin, Andrey A, Zhao, Min, Kumar, Gaurav, Xie, Lin Ying, Jansen, Rick, Milaneschi, Yuri, Dean, Brian, Aberg, Karolina A, van den Oord, Edwin J.C.G, Penninx, Brenda W.J.H

“…Objective:Major depressive disorder is associated with an increased risk of mortality and aging-related diseases. The authors examined whether major depression…”
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Genotype-based ancestral background consistently predicts efficacy and side effects across treatments in CATIE and STARD by Adkins, Daniel E, Souza, Renan P, Aberg, Karolina, Clark, Shaunna L, McClay, Joseph L, Sullivan, Patrick F, van den Oord, Edwin J C G

“…Only a subset of patients will typically respond to any given prescribed drug. The time it takes clinicians to declare a treatment ineffective leaves the…”
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Associations of depression and anxiety symptoms in childhood and adolescence with epigenetic aging by Ingram, Sarah J., Vazquez, Alexandra Y., Klump, Kelly L., Hyde, Luke W., Burt, S. Alexandra, Clark, Shaunna L.

“…Childhood anxiety and depression symptoms are potential risk factors for accelerated biological aging. In child and adolescent twins, we tested whether these…”
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Genes, Environments, and Developmental Research: Methods for a Multi-Site Study of Early Substance Abuse by Costello, E. Jane, Eaves, Lindon, Sullivan, Patrick, Kennedy, Martin, Conway, Kevin, Adkins, Daniel E., Angold, A., Clark, Shaunna L., Erkanli, Alaattin, McClay, Joseph L., Copeland, William, Maes, Hermine H., Liu, Youfang, Patkar, Ashwin A., Silberg, Judy, van den Oord, Edwin

“…The importance of including developmental and environmental measures in genetic studies of human pathology is widely acknowledged, but few empirical studies…”
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Models and Strategies for Factor Mixture Analysis: An Example Concerning the Structure Underlying Psychological Disorders by Clark, Shaunna L., Muthén, Bengt, Kaprio, Jaakko, D'Onofrio, Brian M., Viken, Richard, Rose, Richard J.

“…The factor mixture model (FMM) uses a hybrid of both categorical and continuous latent variables. The FMM is a good model for the underlying structure of…”
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GW-SEM 2.0: Efficient, Flexible, and Accessible Multivariate GWAS by Pritikin, Joshua N., Neale, Michael C., Prom-Wormley, Elizabeth C., Clark, Shaunna L., Verhulst, Brad

“…Most genome-wide association study (GWAS) analyses test the association between single-nucleotide polymorphisms (SNPs) and a single trait or outcome. While…”
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The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood by Clark, Shaunna L., McGinnis, Ellen W., Zhao, Min, Xie, Linying, Marks, Garrett T., Aberg, Karolina A., van den Oord, Edwin J.C.G., Copeland, William E.

“…To test whether childhood mental health symptoms, substance use, and early adversity accelerate the rate of DNA methylation (DNAm) aging from adolescence to…”
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Substance use patterns and mental health comorbidities in youth with a history of depression or suicidality: Findings from TX-YDSRN by Clark, Shaunna L., Dodd, Cody G., Mitchell, Tarrah B., Ingram, Sarah J., Armstrong, Gabrielle M., Jha, Manish K., Soares, Jair C., Smith, Matt, Minhajuddin, Abu, Slater, Holli, Wakefield, Sarah M., Trivedi, Madhukar H.

“…There is a robust relationship between depression and substance use in youth, with higher levels of substance use associated with greater depressive…”
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Evaluating traumatic event scoring schemas for their predictive value to concurrent diagnostic profiles: Texas Childhood Trauma Research Network by Aksan, Nazan, Guzick, Andrew G., Taylor, Leslie, Richmond, Robyn, Liberzon, Israel, Cross, Jeremyra, Garza, Cynthia, Rousseau, Justin, Shahidullah, Jeffrey D., Clark, Shaunna L., Rathouz, Paul J., Dodd, Cody G., Cisler, Josh, Newport, D. Jeffrey, Wagner, Karen D., Nemeroff, Charles B.

“…To prospectively chart pathways of risk and resiliency following childhood trauma studies need to address three limitations of prior work: 1) recruit beyond…”
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Methylomic Investigation of Problematic Adolescent Cannabis Use and Its Negative Mental Health Consequences by Clark, Shaunna L., Chan, Robin, Zhao, Min, Xie, Lin Y., Copeland, William E., Aberg, Karolina A., van den Oord, Edwin J.C.G.

“…The impact of adolescent cannabis use is a pressing public health question owing to the high rates of use and links to negative outcomes. This study considered…”
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Family and social risk, and parental investments during the early childhood years as predictors of low-income children's school readiness outcomes by Mistry, Rashmita S., Benner, Aprile D., Biesanz, Jeremy C., Clark, Shaunna L., Howes, Carollee

“…Using data from the National Early Head Start (EHS) Research and Evaluation Project ( N = 1851), the current study examined relations among cumulative family…”
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