Search Results - "Clark, Rosemary M."

Pathogenic or protective? Neuropeptide Y in amyotrophic lateral sclerosis by Clark, Courtney M., Clark, Rosemary M., Hoyle, Joshua A., Dickson, Tracey C.

“…Neuropeptide Y (NPY) is an endogenous peptide of the central and enteric nervous systems which has gained significant interest as a potential neuroprotective…”
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Synaptic remodeling follows upper motor neuron hyperexcitability in a rodent model of TDP-43 by Dyer, Marcus S., Odierna, G. Lorenzo, Clark, Rosemary M., Woodhouse, Adele, Blizzard, Catherine A.

“…Amyotrophic Lateral Sclerosis (ALS) is an incurable disease characterized by relentlessly progressive degeneration of the corticomotor system. Cortical…”
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Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function by Jiang, Tongcui, Handley, Emily, Brizuela, Mariana, Dawkins, Edgar, Lewis, Katherine E A, Clark, Rosemary M, Dickson, Tracey C, Blizzard, Catherine A

“…Altered cortical excitability and synapse dysfunction are early pathogenic events in amyotrophic lateral sclerosis (ALS) patients and animal models. Recent…”
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Reduced Excitability and Increased Neurite Complexity of Cortical Interneurons in a Familial Mouse Model of Amyotrophic Lateral Sclerosis by Clark, Rosemary M, Brizuela, Mariana, Blizzard, Catherine A, Dickson, Tracey C

“…Cortical interneurons play a crucial role in regulating inhibitory-excitatory balance in brain circuits, filtering synaptic information and dictating the…”
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Intranasal neuropeptide Y1 receptor antagonism improves motor deficits in symptomatic SOD1 ALS mice by Clark, Rosemary M., Clark, Courtney M., Lewis, Katherine E.A., Dyer, Marcus S., Chuckowree, Jyoti A., Hoyle, Joshua A., Blizzard, Catherine A., Dickson, Tracey C.

“…Abstract Objective Neuropeptide Y (NPY) is a 36 amino acid peptide widely considered to provide neuroprotection in a range of neurodegenerative diseases. In…”
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Differential NPY-Y1 Receptor Density in the Motor Cortex of ALS Patients and Familial Model of ALS by Clark, Courtney M., Clark, Rosemary M., Hoyle, Joshua A., Chuckowree, Jyoti A., McLean, Catriona A., Dickson, Tracey C.

“…Destabilization of faciliatory and inhibitory circuits is an important feature of corticomotor pathology in amyotrophic lateral sclerosis (ALS). While…”
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Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies by Handley, Emily E, Pitman, Kimberley A, Dawkins, Edgar, Young, Kaylene M, Clark, Rosemary M, Jiang, Tongcui C, Turner, Bradley J, Dickson, Tracey C, Blizzard, Catherine A

“…TDP-43 is a major protein component of pathological neuronal inclusions that are present in frontotemporal dementia and amyotrophic lateral sclerosis. We…”
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Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1G93A mouse model of ALS by Clark, Rosemary M., Blizzard, Catherine A., Young, Kaylene M., King, Anna E., Dickson, Tracey C.

“…Increasing evidence indicates an excitatory/inhibitory imbalance may have a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Impaired…”
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Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1 G93A mouse model of ALS by Clark, Rosemary M, Blizzard, Catherine A, Young, Kaylene M, King, Anna E, Dickson, Tracey C

“…Increasing evidence indicates an excitatory/inhibitory imbalance may have a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Impaired…”
Get full text