Search Results - "Clark, Richard V."

Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging by Correa-de-Araujo, Rosaly, Addison, Odessa, Miljkovic, Iva, Goodpaster, Bret H, Bergman, Bryan C, Clark, Richard V, Elena, Joanne W, Esser, Karyn A, Ferrucci, Luigi, Harris-Love, Michael O, Kritchevsky, Steve B, Lorbergs, Amanda, Shepherd, John A, Shulman, Gerald I, Rosen, Clifford J

“…Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases with aging and is recognized to negatively correlate with…”
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Creatine ( methyl-d 3 ) dilution in urine for estimation of total body skeletal muscle mass: accuracy and variability vs. MRI and DXA by Clark, Richard V, Walker, Ann C, Miller, Ram R, O'Connor-Semmes, Robin L, Ravussin, Eric, Cefalu, William T

“…A noninvasive method to estimate muscle mass based on creatine ( methyl-d ) (D -creatine) dilution using fasting morning urine was evaluated for accuracy and…”
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Prevalence of Symptomatic Androgen Deficiency in Men by Araujo, Andre B., Esche, Gretchen R., Kupelian, Varant, O’Donnell, Amy B., Travison, Thomas G., Williams, Rachel E., Clark, Richard V., McKinlay, John B.

“…Context: Despite recognition that androgen deficiency in men should be defined according to biochemical and clinical criteria, most prevalence estimates are…”
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Total body skeletal muscle mass: estimation by creatine (methyl-d3) dilution in humans by Clark, Richard V, Walker, Ann C, O'Connor-Semmes, Robin L, Leonard, Michael S, Miller, Ram R, Stimpson, Stephen A, Turner, Scott M, Ravussin, Eric, Cefalu, William T, Hellerstein, Marc K, Evans, William J

“…Current methods for clinical estimation of total body skeletal muscle mass have significant limitations. We tested the hypothesis that creatine (methyl-d3)…”
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Association of sex hormones and C-reactive protein levels in men by Kupelian, Varant, Chiu, Gretchen R., Araujo, Andre B., Williams, Rachel E., Clark, Richard V., McKinlay, John B.

“…Summary Objectives  The age‐associated decline in sex hormone levels in men is paralleled by an increase in cardiovascular disease and associated risk factors…”
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Lean mass, muscle strength, and physical function in a diverse population of men: a population-based cross-sectional study by Araujo, Andre B, Chiu, Gretchen R, Kupelian, Varant, Hall, Susan A, Williams, Rachel E, Clark, Richard V, McKinlay, John B

“…Age-related declines in lean body mass appear to be more rapid in men than in women but our understanding of muscle mass and function among different subgroups…”
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The Natural History of Symptomatic Androgen Deficiency in Men: Onset, Progression, and Spontaneous Remission by Travison, Thomas G., Shackelton, Rebecca, Araujo, Andre B., Hall, Susan A., Williams, Rachel E., Clark, Richard V., O'Donnell, Amy B., McKinlay, John B.

“…OBJECTIVES: To describe the onset, progression, and remission of symptomatic androgen deficiency (SAD) using longitudinal data from the Massachusetts Male…”
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Predictivity of Nonclinical Male Reproductive Findings for Human Effects by Scialli, Anthony R., Clark, Richard V., Chapin, Robert E.

“…Background Testing of pharmaceutical products for reproductive toxicity in male laboratory animals is required for registration. Methods We evaluated whether…”
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Growth Hormone (GH) Replacement Therapy in Adult-Onset GH Deficiency: Effects on Body Composition in Men and Women in a Double-Blind, Randomized, Placebo-Controlled Trial by Hoffman, Andrew R., Kuntze, Joyce E., Baptista, Joyce, Baum, Howard B. A., Baumann, Gerhard P., Biller, Beverly M. K., Clark, Richard V., Cook, David, Inzucchi, Silvio E., Kleinberg, David, Klibanski, Anne, Phillips, Lawrence S., Ridgway, E. Chester, Robbins, Richard J., Schlechte, Janet, Sharma, Meeta, Thorner, Michael O., Vance, Mary Lee

“…Adult GH deficiency (AGHD) is characterized by an altered body composition, an atherogenic lipid profile, decreased exercise capacity, and diminished quality…”
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GSK2881078, a SARM, produces dose-dependent increases in lean mass in healthy older men and women by Neil, David, Clark, Richard V, Magee, Mindy, Billiard, Julia, Chan, Ann, Xue, Zhengyu, Russell, Alan

“…GlaxoSmithKline (GSK) 2881078 is a nonsteroidal, selective androgen receptor modulator (SARM) under investigation by GSK for treatment of reduced mobility and…”
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Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury by Billin, Andrew N, Honeycutt, Samuel E, McDougal, Alan V, Kerr, Jaclyn P, Chen, Zhe, Freudenberg, Johannes M, Rajpal, Deepak K, Luo, Guizhen, Kramer, Henning Fritz, Geske, Robert S, Fang, Frank, Yao, Bert, Clark, Richard V, Lepore, John, Cobitz, Alex, Miller, Ram, Nosaka, Kazunori, Hinken, Aaron C, Russell, Alan J

“…Following publication of the original article [1], the authors flagged that there is a discrepancy with the Availability of data and materials statement on…”
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Safety, pharmacokinetics and pharmacological effects of the selective androgen receptor modulator, GSK2881078, in healthy men and postmenopausal women by Clark, Richard V., Walker, Ann C., Andrews, Susan, Turnbull, Philip, Wald, Jeffrey A., Magee, Mindy H.

“…Aim Selective androgen receptor modulators (SARMs) induce anabolic effects on muscle without the adverse effects of androgenic steroids. In this first‐in‐human…”
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Large divergence in testosterone concentrations between men and women: Frame of reference for elite athletes in sex‐specific competition in sports, a narrative review by Clark, Richard V., Wald, Jeffrey A., Swerdloff, Ronald S., Wang, Christina, Wu, Frederick C. W., Bowers, Larry D., Matsumoto, Alvin M.

“…Summary Objective The purpose of this narrative review was to summarize available data on testosterone levels in normal, healthy adult males and females, to…”
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Menopause-specific questionnaire assessment in US population-based study shows negative impact on health-related quality of life by Williams, Rachel E, Levine, Kristen B, Kalilani, Linda, Lewis, Jacqueline, Clark, Richard V

“…Abstract Objective To use the Menopause-Specific Quality of Life Questionnaire (MENQOL) to assess the impact of menopausal symptoms on health-related quality…”
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HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury by Billin, Andrew N, Honeycutt, Samuel E, McDougal, Alan V, Kerr, Jaclyn P, Chen, Zhe, Freudenberg, Johannes M, Rajpal, Deepak K, Luo, Guizhen, Kramer, Henning Fritz, Geske, Robert S, Fang, Frank, Yao, Bert, Clark, Richard V, Lepore, John, Cobitz, Alex, Miller, Ram, Nosaka, Kazunori, Hinken, Aaron C, Russell, Alan J

“…In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect…”
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The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men by Amory, John K., Wang, Christina, Swerdloff, Ronald S., Anawalt, Bradley D., Matsumoto, Alvin M., Bremner, William J., Walker, Susan E., Haberer, Lynda J., Clark, Richard V.

“…Context: Dutasteride and finasteride are 5α-reductase inhibitors (5ARIs) that dramatically reduce serum levels of dihydrotestosterone (DHT). Objective: Because…”
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Association between low muscle mass, functional limitations and hospitalisation in heart failure: NHANES 1999-2004 by DiBello, Julia R, Miller, Ram, Khandker, Rezaul, Bourgeois, Nancy, Galwey, Nicholas, Clark, Richard V

“…Muscle mass decreases with age, and heart failure (HF) patients may experience greater reductions due to pathophysiological processes associated with this…”
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Correlates of Low Testosterone and Symptomatic Androgen Deficiency in a Population-Based Sample by Hall, Susan A., Esche, Gretchen R., Araujo, Andre B., Travison, Thomas G., Clark, Richard V., Williams, Rachel E., McKinlay, John B.

“…Context: Risk factors for low testosterone and symptomatic androgen deficiency (AD) may be modifiable. Objective: Our objective was to examine demographic,…”
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Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor by Clark, Richard V., Hermann, David J., Cunningham, Glenn R., Wilson, Timothy H., Morrill, Betsy B., Hobbs, Stuart

“…Dihydrotestosterone (DHT) is the primary metabolite of testosterone in the prostate and skin. Testosterone is converted to DHT by 5α-reductase, which exists in…”
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Healthcare seeking and treatment for menopausal symptoms in the United States by Williams, Rachel E, Kalilani, Linda, DiBenedetti, Dana Britt, Zhou, Xiaolei, Fehnel, Sheri E, Clark, Richard V

“…Abstract Objectives A population-based study was used to describe healthcare seeking behavior for menopausal symptoms and treatment among women 40–65 years old…”
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