Search Results - "Clark, Mark E"

Delayed Rod-Mediated Dark Adaptation Is a Functional Biomarker for Incident Early Age-Related Macular Degeneration by Owsley, Cynthia, PhD, McGwin, Gerald, PhD, Clark, Mark E., BS, Jackson, Gregory R., PhD, Callahan, Michael A., MD, Kline, Lanning B., MD, Witherspoon, C. Douglas, MD, Curcio, Christine A., PhD

“…Purpose To examine whether slowed rod-mediated dark adaptation (DA) in adults with normal macular health at baseline is associated with the incidence of…”
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In vivo optic nerve head mechanical response to intraocular and cerebrospinal fluid pressure: imaging protocol and quantification method by Fazio, Massimo A., Clark, Mark E., Bruno, Luigi, Girkin, Christopher A.

“…This study presents a quantification method for the assessment of the optic nerve head (ONH) deformations of the living human eye under acute intraocular…”
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Abundant lipid and protein components of drusen by Wang, Lan, Clark, Mark E, Crossman, David K, Kojima, Kyoko, Messinger, Jeffrey D, Mobley, James A, Curcio, Christine A

“…Drusen are extracellular lesions characteristic of aging and age-related maculopathy, a major retinal disease of the elderly. We determined the relative…”
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No evidence of physiological declines with age in an extremely long-lived fish by Sauer, Derek J., Heidinger, Britt J., Kittilson, Jeffrey D., Lackmann, Alec R., Clark, Mark E.

“…Although the pace of senescence varies considerably, the physiological systems that contribute to different patterns of senescence are not well understood,…”
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Analysis of bigmouth buffalo Ictiobus cyprinellus spawning phenology in Minnesota reveals 50-year recruitment failure and conservation concern by Lackmann, Alec R., Seybold, Sam, Bielak-Lackmann, Ewelina S., Ford, Walt, Butler, Malcolm G., Clark, Mark E.

“…The bigmouth buffalo Ictiobus cyprinellus (Catostomidae) is a freshwater fish native to North America that is known for its longevity. During the 1970s, the…”
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Photoreceptor Perturbation Around Subretinal Drusenoid Deposits as Revealed by Adaptive Optics Scanning Laser Ophthalmoscopy by Zhang, Yuhua, Wang, Xiaolin, Rivero, Ernesto Blanco, Clark, Mark E, Witherspoon, Clark Douglas, Spaide, Richard F, Girkin, Christopher A, Owsley, Cynthia, Curcio, Christine A

“…Purpose To describe the microscopic structure of photoreceptors impacted by subretinal drusenoid deposits, also called pseudodrusen, an extracellular lesion…”
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Prevalence of Subretinal Drusenoid Deposits in Older Persons with and without Age-Related Macular Degeneration, by Multimodal Imaging by Zarubina, Anna V., MD, Neely, David C., MD, Clark, Mark E., BS, Huisingh, Carrie E., MPH, Samuels, Brian C., MD, PhD, Zhang, Yuhua, PhD, McGwin, Gerald, MS, PhD, Owsley, Cynthia, PhD, MSPH, Curcio, Christine A., PhD

“…Purpose To assess the prevalence of subretinal drusenoid deposits (SDD) in older adults with healthy maculas and early and intermediate age-related macular…”
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Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods by Curcio, Christine A, McGwin, Jr, Gerald, Sadda, Srinivas R, Hu, Zhihong, Clark, Mark E, Sloan, Kenneth R, Swain, Thomas, Crosson, Jason N, Owsley, Cynthia

“…Age-related macular degeneration (AMD), a leading cause of irreversible vision impairment in the United States and globally, is a disease of the photoreceptor…”
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Highly Efficient Delivery of Adeno-Associated Viral Vectors to the Primate Retina by Boye, Shannon E, Alexander, John J, Witherspoon, C Douglas, Boye, Sanford L, Peterson, James J, Clark, Mark E, Sandefer, Kristen J, Girkin, Chris A, Hauswirth, William W, Gamlin, Paul D

“…Adeno-associated virus (AAV) has emerged as the preferred vector for targeting gene expression to the retina. Subretinally injected AAV can efficiently…”
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Evidence that Cryptosporidium parvum Populations Are Panmictic and Unstructured in the Upper Midwest of the United States by HERGES, Grant R, WIDMER, Giovanni, CLARK, Mark E, KHAN, Eakalak, GIDDINGS, Catherine W, BREWER, Matt, MCEVOY, John M

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Apolipoprotein Localization in Isolated Drusen and Retinal Apolipoprotein Gene Expression by Li, Chuan-Ming, Clark, Mark E, Chimento, Melissa F, Curcio, Christine A

“…To evaluate apolipoprotein (Apo) gene expression in native human retinal pigment epithelium (RPE) and neurosensory retina and to detect apolipoproteins within…”
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Maternal Effects Increase Within‐Family Variation in Offspring Survival by Reed, Wendy L., Clark, Mark E., Vleck, Carol M.

“…Maternal effects are environmental components of phenotypes that complicate relationships between natural selection and evolution because they often affect…”
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Patients' Adherence to Recommended Follow-up Eye Care After Diabetic Retinopathy Screening in a Publicly Funded County Clinic and Factors Associated With Follow-up Eye Care Use by Keenum, Zachary, McGwin, Jr, Gerald, Witherspoon, C Douglas, Haller, Julia A, Clark, Mark E, Owsley, Cynthia

“…The public health success of diabetic retinopathy (DR) screening programs depends on patients' adherence to the timetable of follow-up eye care recommended by…”
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Choriocapillaris Impairment Is Associated With Delayed Rod-Mediated Dark Adaptation in Age-Related Macular Degeneration by Kar, Deepayan, Corradetti, Giulia, Swain, Thomas A, Clark, Mark E, McGwin, Jr, Gerald, Owsley, Cynthia, Sadda, SriniVas R, Curcio, Christine A

“…Progress toward treatment and prevention of age-related macular degeneration (AMD) requires imaging end points that relate to vision. We investigated…”
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Distribution and composition of esterified and unesterified cholesterol in extra-macular drusen by Li, Chuan-Ming, Clark, Mark E., Rudolf, Martin, Curcio, Christine A.

“…More details about the distribution of esterified and unesterified cholesterol (EC, UC), abundant druse components, would inform models of druse biogenesis and…”
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Retinal pigment epithelium degeneration associated with subretinal drusenoid deposits in age-related macular degeneration by Xu, Xiaoyu, Liu, Xing, Wang, Xiaolin, Clark, Mark E, McGwin, Gerald, Owsley, Cynthia, Curcio, Christine A, Zhang, Yuhua

“…Purpose To test whether increased light transmission (hypertransmission) through subretinal drusenoid deposits (SDD) into the choroid in age-related macular…”
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Extent and Topography of Subretinal Drusenoid Deposits Associate With Rod-Mediated Vision in Aging and AMD: ALSTAR2 Baseline by Goerdt, Lukas, Amjad, Mohymina, Swain, Thomas A, McGwin, Gerald, Clark, Mark E, Owsley, Cynthia, Sloan, Kenneth R, Curcio, Christine A, Kar, Deepayan

“…In AMD, rod-mediated dark adaptation (RMDA) at 5° eccentricity is slower in eyes with subretinal drusenoid deposits (SDDs) than in eyes without. Here we…”
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Prevalence of Undiagnosed Age-Related Macular Degeneration in Primary Eye Care by Neely, David C, Bray, Kevin J, Huisingh, Carrie E, Clark, Mark E, McGwin, Jr, Gerald, Owsley, Cynthia

“…Age-related macular degeneration (AMD) is the leading cause of irreversible vision impairment in older adults in the United States, yet little is known about…”
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Displacement of the Lamina Cribrosa With Acute Intraocular Pressure Increase in Brain-Dead Organ Donors by Girkin, Christopher A, Garner, Mary A, Gardiner, Stuart K, Clark, Mark E, Hubbard, Meredith, Karuppanan, Udayakumar, Bianco, Gianfranco, Bruno, Luigi, Fazio, Massimo A

“…To examine deformations of the optic nerve head (ONH) deep tissues in response to acute elevation of intraocular pressure (IOP). Research-consented brain-dead…”
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Comparison of Visual Function in Older Eyes in the Earliest Stages of Age-related Macular Degeneration to Those in Normal Macular Health by Owsley, Cynthia, Huisingh, Carrie, Clark, Mark E., Jackson, Gregory R., McGwin, Gerald

“…Purpose: To compare the ability of several visual functional tests in terms of the strength of their associations with the earliest phases of age-related…”
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