Search Results - "Clark, Larry C."

Nutritional Prevention of Cancer: 400 Mcg Per Day Selenium Treatment by Reid, M.E, Duffield-Lillico, A.J, Slate, E, Natarajan, N, Turnbull, B, Jacobs, E, Combs, G.F. Jr, Alberts, D.S, Clark, L.C, Marshall, J.R

“…Nonexperimental studies suggest that individuals with higher selenium (Se) status are at decreased risk of cancer. The Nutritional Prevention of Cancer (NPC)…”
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Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines by Redman, Claire, Scott, Julie A, Baines, Antonio T, Basye, Jenny L, Clark, Larry C, Calley, Cindy, Roe, Denise, Payne, Claire M, Nelson, Mark A

“…Selenium supplementation has been shown for many years to work as an anticarcinogenic agent both in epidemiology and in in vitro studies. Selenium…”
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Randomized, controlled chemoprevention trials in populations at very high risk for prostate cancer: Elevated prostate-specific antigen and high-grade prostatic intraepithelial neoplasia by Clark, Larry C, Marshall, James R

“…This is a report of research efforts underway at the Arizona Cancer Center. These efforts build upon Larry Clark’s unanticipated clinical prevention trial…”
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Effects of Selenium Supplementation on Cardiovascular Disease Incidence and Mortality: Secondary Analyses in a Randomized Clinical Trial by Stranges, Saverio, Marshall, James R, Trevisan, Maurizio, Natarajan, Raj, Donahue, Richard P, Combs, Gerald F, Farinaro, Eduardo, Clark, Larry C, Reid, Mary E

“…Despite the documented antioxidant and chemopreventive properties of selenium, studies of selenium intake and supplementation and cardiovascular disease have…”
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Baseline characteristics and the effect of selenium supplementation on Cancer incidence in a randomized clinical trial: A summary report of the Nutritional Prevention of Cancer trial by DUFFIELD-LILLICO, Anna J, REID, Mary E, TURNBULL, Bruce W, COMBS, Gerald F, SLATE, Elizabeth H, FISCHBACH, Lori A, MARSHALL, James R, CLARK, Larry C

“…The Nutritional Prevention of Cancer Trial was a randomized, clinical trial designed to evaluate the efficacy of selenium as selenized yeast (200 microg daily)…”
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Selenium Supplementation and Secondary Prevention of Nonmelanoma Skin Cancer in a Randomized Trial by Duffield-Lillico, Anna J., Slate, Elizabeth H., Reid, Mary E., Turnbull, Bruce W., Wilkins, Patricia A., Combs, Gerald F., Park, H. Kim, Gross, Earl G., Graham, Gloria F., Stratton, M. Suzanne, Marshall, James R., Clark, Larry C.

“…The Nutritional Prevention of Cancer Trial was a double-blind, randomized, placebo-controlled clinical trial designed to test whether selenium as selenized…”
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Selenium supplementation and lung Cancer incidence: An update of the nutritional prevention of Cancer trial by REID, Mary E, DUFFIELD-LILLICO, Anna J, GARLAND, Linda, TURNBULL, Bruce W, CLARK, Larry C, MARSHALL, James R

“…Interest in the chemopreventive effects of the trace element selenium has spanned the past three decades. Of >100 studies that have investigated the effects of…”
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Monitoring for clusters of disease: application to leukemia incidence in upstate New York by Turnbull, B W, Iwano, E J, Burnett, W S, Howe, H L, Clark, L C

“…The authors propose a procedure for the detection of significant clusters of chronic diseases, with particular reference to cancer. The procedure allows for…”
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A report of high-dose selenium supplementation: response and toxicities by Reid, Mary E., Stratton, M.Suzanne, Lillico, Anna J., Fakih, Marwan, Natarajan, Raj, Clark, Larry C., Marshall, James R.

“…Concerns about the toxicity of selenium has limited the doses used in chemoprevention. Based on previous studies, intakes of 400 μg/day and plasma selenium of…”
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Oral selenium supplementation has no effect on prostate-specific antigen velocity in men undergoing active surveillance for localized prostate cancer by Stratton, M Suzanne, Algotar, Amit M, Ranger-Moore, James, Stratton, Steven P, Slate, Elizabeth H, Hsu, Chiu-Hsieh, Thompson, Patricia A, Clark, Larry C, Ahmann, Frederick R

“…The Nutritional Prevention of Cancer trial showed a 52% lower incidence of prostate cancer in men supplemented with selenium. As a result, our study was…”
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Semiparametric Regression Models for Repeated Events with Random Effects and Measurement Error by Jiang, Wenxin, Turnbull, Bruce W., Clark, Larry C.

“…Statistical methodology is presented for the regression analysis of multiple events in the presence of random effects and measurement error. Omitted covariates…”
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The effects of dietary selenomethionine on polyamines and azoxymethane-induced aberrant crypts by Baines, Antonio T, Holubec, Hanna, Basye, Jenny L, Thorne, Patricia, Bhattacharyya, Achyut K, Spallholz, Julian, Shriver, Brent, Cui, Haiyan, Roe, Denise, Clark, Larry C, Earnest, David L, Nelson, Mark A

“…We evaluated the effects of dietary selenomethionine supplementation on colonic polyamine levels and the ability of l-selenomethionine supplementation to…”
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Experiences at a large teaching hospital with levofloxacin for the treatment of community-acquired pneumonia by Clark, LC, Davis, CW

“…Costs, patient outcomes, and susceptibility patterns of selected organisms after the implementation of guidelines for the treatment of community-acquired…”
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Langerhans Cell Histiocytosis With Orbital Involvement by KRAMER, THERESA R., NOECKER, ROBERT J., MILLER, JOSEPH M., CLARK, LARRY C.

“…To review three cases of Langerhans cell histiocytosis with orbital involvement that represent a significantly excessive incidence of this rare disease in one…”
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Selenium and cancer: risk or protection? by Clark, L C, Alberts, D S

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SLE in a United States-Mexico Border Community by Walsh, Bridget T, Pope, Cynthia, Reid, Mary, Gall, Eric P, Yocum, David E, Clark, Larry C

“…This report describes the results of a clinic-based study conducted to verify a community-reported excess prevalence of systemic lupus erythematosus (SLE) and…”
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Selenium Supplementation and Cancer Rates-Reply by Clark, Larry C, Combs, Gerald F, Turnbull, Bruce W, Slate, Elizabeth H

“…In Reply.—We share Dr Herbert's concern regarding the safety of using 200 μg of selenium in a high-selenium brewer's yeast and have been concerned about…”
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Analysis of Multi-Type Recurrent Events in Longitudinal Studies; Application to a Skin Cancer Prevention Trial by Abu-Libdeh, Hasan, Turnbull, Bruce W., Clark, Larry C.

“…We consider the statistical modeling and analysis of replicated multi-type point process data with covariates. Such data arise when heterogeneous subjects…”
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A computer program for sample size and power calculations in the design of multi-arm and factorial clinical trials with survival time endpoints by Natarajan, Ranjini, Turnbull, Bruce W., Slate, Elizabeth H., Clark, Larry C.

“…This paper presents a computer program for use in the design of long-term clinical trials with multiple treatment arms in which the primary outcome variables…”
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Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin: A Randomized Controlled Trial by Clark, Larry C, Combs, Gerald F, Turnbull, Bruce W, Slate, Elizabeth H, Chalker, Dan K, Chow, James, Davis, Loretta S, Glover, Renee A, Graham, Gloria F, Gross, Earl G, Krongrad, Arnon, Lesher, Jack L, Park, H. Kim, Sanders, Beverly B, Smith, Cameron L, Taylor, J. Richard

“…Objective.—To determine whether a nutritional supplement of selenium will decrease the incidence of cancer.Design.—A multicenter, double-blind, randomized,…”
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