Search Results - "Clark, Kimberly A."

K2P2.1 (TREK-1)–activator complexes reveal a cryptic selectivity filter binding site by Lolicato, Marco, Arrigoni, Cristina, Mori, Takahiro, Sekioka, Yoko, Bryant, Clifford, Clark, Kimberly A., Minor, Daniel L.

“…Crystal structures of an activated two-pore potassium channel reveal a cryptic binding pocket that binds small-molecule activators that restrict the mobility…”
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Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels by Lolicato, Marco, Riegelhaupt, Paul M., Arrigoni, Cristina, Clark, Kimberly A., Minor, Daniel L.

“…Mechanical and thermal activation of ion channels is central to touch, thermosensation, and pain. The TRAAK/TREK K2P potassium channel subfamily produces…”
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A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels by Bagriantsev, Sviatoslav N, Ang, Kean-Hooi, Gallardo-Godoy, Alejandra, Clark, Kimberly A, Arkin, Michelle R, Renslo, Adam R, Minor, Daniel L

“…K2P (KCNK) potassium channels generate “leak” potassium currents that strongly influence cellular excitability and contribute to pain, somatosensation,…”
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Evaluation of the Central Effects of Systemic Lentiviral-Mediated Leptin Delivery in Streptozotocin-Induced Diabetic Rats by Clark, Kimberly A, Shin, Andrew C, Sirivelu, Madhu P, MohanKumar, Ramya C, Maddineni, Sreenivasa R, Ramachandran, Ramesh, MohanKumar, Puliyur S, MohanKumar, Sheba M J

“…Type 1 diabetes (T1D) is characterized by hyperphagia, hyperglycemia and activation of the hypothalamic-pituitary-adrenal (HPA) axis. We have reported…”
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Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains by Bagriantsev, Sviatoslav N, Clark, Kimberly A, Minor Jr, Daniel L

“…K 2P 2.1 (TREK‐1) is a polymodal two‐pore domain leak potassium channel that responds to external pH, GPCR‐mediated phosphorylation signals, and temperature…”
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Systemic administration of leptin decreases plasma corticosterone levels: Role of hypothalamic norepinephrine by Clark, Kimberly A, Shin, Andew C, Sirivelu, Madhu P, MohanKumar, Sheba M.J, MohanKumar, P.S

“…Abstract Leptin, an adipocyte-derived hormone, is known to regulate a variety of neuroendocrine functions. It inhibits the hypothalamo-pituitary-adrenal axis…”
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Multiple modalities converge on a common gate to control K2P channel function by Bagriantsev, Sviatoslav N, Peyronnet, Rémi, Clark, Kimberly A, Honoré, Eric, Minor Jr, Daniel L

“…Members of the K 2P potassium channel family regulate neuronal excitability and are implicated in pain, anaesthetic responses, thermosensation,…”
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Leptin and HPA axis activity in diabetic rats: Effects of adrenergic agonists by Clark, Kimberly A., Jacob, Elyssa B., MohanKumar, P.S., MohanKumar, Sheba M.J.

“…•Type 1 diabetes causes an increase in NE release in the PVN and serum corticosterone levels.•The brain of diabetic animals is less sensitive to leptin…”
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Structural Insight into KCNQ (Kv7) Channel Assembly and Channelopathy by Howard, Rebecca J., Clark, Kimberly A., Holton, James M., Minor, Daniel L.

“…Kv7.x (KCNQ) voltage-gated potassium channels form the cardiac and auditory I Ks current and the neuronal M-current. The five Kv7 subtypes have distinct…”
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Structure of a complex between a voltage-gated calcium channel β-subunit and an α-subunit domain by Minor, Daniel L, Van Petegem, Filip, Clark, Kimberly A, Chatelain, Franck C

“…Voltage-gated calcium channels (CaVs) govern muscle contraction, hormone and neurotransmitter release, neuronal migration, activation of calcium-dependent…”
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Chronic estrogen exposure affects gene expression in the rostral ventrolateral medulla of young and aging rats: Possible role in hypertension by Subramanian, Madhan, Hahn-Townsend, Coral, Clark, Kimberly A, MohanKumar, Sheba M.J, MohanKumar, P.S

“…Abstract Background Chronic exposure to estradiol-17β (E2) in adult female rats increases mean arterial pressure by stimulating superoxide production in the…”
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Multiple modalities converge on a common gate to control K 2P channel function by Minor, Daniel L, Bagriantsev, Sviatoslav N, Peyronnet, Rémi, Clark, Kimberly A, Honoré, Eric

“…Members of the K2P potassium channel family regulate neuronal excitability and are implicated in pain, anaesthetic responses, thermosensation, neuroprotection,…”
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Tethered Protein Display Identifies a Novel Kir3.2 (GIRK2) Regulator from Protein Scaffold Libraries by Bagriantsev, Sviatoslav N, Chatelain, Franck C, Clark, Kimberly A, Alagem, Noga, Reuveny, Eitan, Minor, Daniel L

“…Use of randomized peptide libraries to evolve molecules with new functions provides a means for developing novel regulators of protein activity. Despite the…”
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Effects of central and systemic administration of leptin on neurotransmitter concentrations in specific areas of the hypothalamus by Clark, Kimberly A, MohanKumar, Sheba M J, Kasturi, Badrinarayanan S, MohanKumar, P S

“…Leptin, a hormone produced by adipocytes, has been shown to affect a number of central functions, such as regulation of the hypothalamo-pituitary-adrenal axis,…”
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Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels by Lolicato, Marco, Riegelhaupt, Paul M, Arrigoni, Cristina, Clark, Kimberly A, Minor, Jr, Daniel L

“…Mechanical and thermal activation of ion channels is central to touch, thermosensation, and pain. The TRAAK/TREK K(2P) potassium channel subfamily produces…”
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Methods for engineering therapeutic peptides by Li, Yaohao, Clark, Kimberly A., Tan, Zhongping

“…This review discussed recent advancements related to therapeutic peptide engineering. [Display omitted] Peptides are a class of drugs that have become…”
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K2P2.1 (TREK-1)-Activator Complexes Reveal a Cryptic Selectivity Filter Binding Site by Lolicato, Marco, Arrigoni, Cristina, Mori, Takahiro, Sekioka, Yoko, Bryant, Clifford, Clark, Kimberly A., Minor, Daniel L.

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K^sub 2P^2.1 (TREK-1)–activator complexes reveal a cryptic selectivity filter binding site by Lolicato, Marco, Arrigoni, Cristina, Mori, Takahiro, Sekioka, Yoko, Bryant, Clifford, Clark, Kimberly A, Minor, Daniel L

“…Polymodal thermo- and mechanosensitive two-pore domain potassium (K2P) channels of the TREK1 subfamily generate 'leak' currents that regulate neuronal…”
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Finding Me in Ministry: Using the Principles of Kwanzaa as a Resource for Discerning the Uniqueness of One’s Personal and Cultural Call by Clark, Kimberly A

“…Traditionally, a person who expresses a call to ministry might be encouraged by the pastor to complete a preparation process; however, that process rarely…”
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K.sub.2P2.1 -activator complexes reveal a cryptic selectivity filter binding site by Lolicato, Marco, Arrigoni, Cristina, Mori, Takahiro, Sekioka, Yoko, Bryant, Clifford, Clark, Kimberly A, Minor, Daniel L., Jr

“…Crystal structures of an activated two-pore potassium channel reveal a cryptic binding pocket that binds small-molecule activators that restrict the mobility…”
Get full text